Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 753 free, full-text research articles on human participants. First 3 results:

Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis.
 

Author(s): Zhongxiao Lin, Sisi Li, Hansong Sheng, Ming Cai, Lin Yuan Si Ma, Liuxun Hu, Shangyu Xu, Li Sheng Yu, Nu Zhang

Journal: J. Cancer Res. Clin. Oncol.. 2016 Dec;142(12):2469-2478.

 

The sonic hedgehog (SHH) signalling pathway plays the important role in medulloblastoma (MB). Altered GLI expression plays a key role in these processes, and the inhibition of GLI may be a good cancer-targeted therapy. This study aimed to investigate whether GANT61, a GLI inhibitor, ...

Last Updated: 7 Sep 2016

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Update on the integrated histopathological and genetic classification of medulloblastoma - a practical diagnostic guideline.
 

Author(s): Torsten Pietsch, Christine Haberler

Journal: Clin. Neuropathol.. ;35(6):344-352.

 

The revised WHO classification of tumors of the CNS 2016 has introduced the concept of the integrated diagnosis. The definition of medulloblastoma entities now requires a combination of the traditional histological information with additional molecular/genetic features. For definition ...

Last Updated: 26 Oct 2016

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Treatment of medulloblastoma in children and adolescents.
 

Author(s): Nelci Zanon Collange, Silvana de Azevedo Brito, Ricardo Rezende Campos, Egmond Alves Silva Santos, Ricardo Vieira Botelho,

Journal: Rev Assoc Med Bras (1992). 2016 Jul;62(4):298-302.

 

Last Updated: 21 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 49 free, full-text review articles on human participants. First 3 results:

Medulloblastoma stem cells: Promising targets in medulloblastoma therapy.
 

Author(s): Guo-Hao Huang, Qing-Fu Xu, You-Hong Cui, Ningning Li, Xiu-Wu Bian, Sheng-Qing Lv

Journal: Cancer Sci.. 2016 May;107(5):583-9.

 

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Despite great improvements in the therapeutic regimen, relapse and leptomeningeal dissemination still pose great challenges to the long-term survival of MB patients. Developing more effective strategies has become ...

Last Updated: 13 May 2016

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[Medulloblastoma in adults: report of 13 cases and literature review].
 

Author(s): Jamal Drissi, Mariam Affane, Abdelhamid Elomrani, Mouna Khouchani

Journal:

 

Last Updated: 18 Feb 2016

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Young investigator challenge: Cytomorphologic analysis of cerebrospinal fluid in 70 pediatric patients with medulloblastoma and review of the literature focusing on novel diagnostic and prognostic tests.
 

Author(s): Domenico Damiani, Voichita Suciu, Felipe Andreiuolo, Julien Calderaro, Philippe Vielh

Journal: Cancer Cytopathol. 2015 Nov;123(11):644-9.

 

Medulloblastoma (MB) is the most common malignant pediatric brain tumor and is currently treated with combined therapies. Recent advances in genetics and protein expression in this entity have led to the elaboration of a new molecular classification, and novel targeted therapies are ...

Last Updated: 15 Jan 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 10 Nov 2016

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A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 20 Feb 2017

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Last Updated: 28 Jul 2016

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