Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 786 free, full-text research articles on human participants. First 3 results:

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
 

Author(s): Paola Infante, Roberta Faedda, Flavia Bernardi, Francesca Bufalieri, Ludovica Lospinoso Severini, Romina Alfonsi, Daniela Mazzà, Mariangela Siler, Sonia Coni, Agnese Po, Marialaura Petroni, Elisabetta Ferretti, Mattia Mori, Enrico De Smaele, Gianluca Canettieri, Carlo Capalbo, Marella Maroder, Isabella Screpanti, Marcel Kool, Stefan M Pfister, Daniele Guardavaccaro, Alberto Gulino, Lucia Di Marcotullio

Journal:

 

Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh signalling, our understanding ...

Last Updated: 31 Dec 1969

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TAp73 is a marker of glutamine addiction in medulloblastoma.
 

Author(s): Maria Victoria Niklison-Chirou, Ida Erngren, Mikael Engskog, Jakob Haglöf, Daniel Picard, Marc Remke, Phelim Hugh Redmond McPolin, Matthew Selby, Daniel Williamson, Steven C Clifford, David Michod, Michalis Hadjiandreou, Torbjörn Arvidsson, Curt Pettersson, Gerry Melino, Silvia Marino

Journal: Genes Dev.. 2017 09;31(17):1738-1753.

 

Medulloblastoma is the most common solid primary brain tumor in children. Remarkable advancements in the understanding of the genetic and epigenetic basis of these tumors have informed their recent molecular classification. However, the genotype/phenotype correlation of the subgroups ...

Last Updated: 31 Dec 1969

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Coexistence of Radiation-Induced Meningioma and Moyamoya Syndrome 10 Years after Irradiation against Medulloblastoma: a Case Report.
 

Author(s): Ji Yeon Han, Jung Won Choi, Kyu Chang Wang, Ji Hoon Phi, Ji Yeoun Lee, Jong Hee Chae, Sung Hye Park, Jung Eun Cheon, Seung Ki Kim

Journal: J. Korean Med. Sci.. 2017 Nov;32(11):1896-1902.

 

Radiotherapy is one of the standard treatments for medulloblastoma. However, therapeutic central nervous system irradiation in children may carry delayed side effects, such as radiation-induced tumor and vasculopathy. Here, we report the first case of coexisting meningioma and moyamoya ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 60 free, full-text review articles on human participants. First 3 results:

Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update.
 

Author(s): Francisco Bautista, Victoria Fioravantti, Teresa de Rojas, Fernando Carceller, Luis Madero, Alvaro Lassaletta, Lucas Moreno

Journal: Cancer Med. 2017 Nov;6(11):2606-2624.

 

Survival rates for patients with medulloblastoma have improved in the last decades but for those who relapse outcome is dismal and new approaches are needed. Emerging drugs have been tested in the last two decades within the context of phase I/II trials. In parallel, advances in genetic ...

Last Updated: 31 Dec 1969

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Oncogenic role of cytomegalovirus in medulloblastoma?
 

Author(s): Alejandro M Hortal, Jeroen F Vermeulen, Wim Van Hecke, Niels Bovenschen

Journal: Cancer Lett.. 2017 11;408():55-59.

 

Medulloblastoma is the most common solid tumor among children. Current therapeutic strategies for this malignancy include surgical resection, radiation therapy and chemotherapy. However, these treatments are accompanied with serious side effects such as neurological complications ...

Last Updated: 31 Dec 1969

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Delayed diffuse cerebellar swelling after resection of medulloblastoma: case report and review of literature.
 

Author(s): Ashley L B Raghu, Jothy Kandasamy, Mark Brougham, Pasquale Gallo, Drahus Sokol, Mark A Hughes

Journal: Childs Nerv Syst. 2017 Nov;33(11):2047-2049.

 

Delayed diffuse cerebellar swelling is a rare life-threatening complication following medulloblastoma resection.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 5 Oct 2017

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Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 1 Mar 2018

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A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 5 Feb 2018

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