Megaloblastic anemia

Common Name(s)

Megaloblastic anemia, Imerslund-Grasbeck syndrome

Imerslund-Grasbeck syndrome (IGS) is a rare condition characterized by vitamin B12 deficiency, often causing megaloblastic anemia. IGS usually appears in childhood. Other features may include failure to thrive, infections, and neurological damage. Mild proteinuria (with no signs of kidney disease) is present in about half of affected individuals. IGS is caused by mutations in either the CUBN or AMN gene and is inherited in an autosomal recessive manner. Treatment includes life-long vitamin B12 injections, with which affected individuals can stay healthy for decades.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Megaloblastic anemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Megaloblastic anemia" returned 93 free, full-text research articles on human participants. First 3 results:

Megaloblastic Anemia with Ring Sideroblasts is not Always Myelodysplastic Syndrome.
 

Author(s): Neha Chopra Narang, Mrinalini Kotru, Kavana Rao, Meera Sikka

Journal: Turk J Haematol. 2016 Dec;33(4):358-359.

 

Last Updated: 28 Jul 2016

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Bilateral macular hemorrhage due to megaloblastic anemia: A rare case report.
 

Author(s): Sree Kumar Vaggu, Preethi Bhogadi

Journal: Indian J Ophthalmol. 2016 Feb;64(2):157-9.

 

We report a case of a 17-year-old female patient who presented with sudden, painless, nonprogressive diminished vision in both eyes (best corrected visual acuity in right eye - 6/60 and left eye - 6/36). An ophthalmological evaluation revealed bilateral pale tarsal conjunctiva and ...

Last Updated: 7 Apr 2016

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Drug-Induced Megaloblastic Anemia.
 

Author(s): Charles S Hesdorffer, Dan L Longo

Journal: N. Engl. J. Med.. 2016 Feb;374(7):696-7.

 

Last Updated: 18 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Megaloblastic anemia" returned 6 free, full-text review articles on human participants. First 3 results:

Laboratory testing for cobalamin deficiency in megaloblastic anemia.
 

Author(s): Matthew J Oberley, David T Yang

Journal: Am. J. Hematol.. 2013 Jun;88(6):522-6.

 

Cobalamin (vitamin B12) deficiency is a common cause of megaloblastic anemia in Western populations. Laboratory evaluation of megaloblastic anemia frequently includes the assessment of patient cobalamin and folate status. Current total serum cobalamin measurements are performed in ...

Last Updated: 22 May 2013

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Megaloblastic anemia and other causes of macrocytosis.
 

Author(s): Florence Aslinia, Joseph J Mazza, Steven H Yale

Journal: Clin Med Res. 2006 Sep;4(3):236-41.

 

Last Updated: 21 Sep 2006

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Megaloblastic anemia associated with psoriasis: case report and review of the literature.
 

Author(s): A Iwama, A Miwa, T Suzuki, H Ema, T Suda, S Sakamoto, Y Miura

Journal: Intern. Med.. 1992 Jan;31(1):127-30.

 

A 68-yr-old male with severe psoriasis developed megaloblastic anemia due to folate deficiency 3 months after the cessation of low-dose methotrexate therapy. The mechanism of megaloblastic anemia in this case was suggested to be multifactorial. The case report and a review of megaloblastic ...

Last Updated: 28 May 1992

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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