Melanoma

Common Name(s)

Melanoma

Melanoma is the most serious type of skin cancer that develops in cells that produce melanin (melanocytes), which give skin its color. Skin cancer is a life threatening condition, but it can be fully treated if detected early. Symptoms of melanoma include a change to an existing mole or the development of an abnormal growth on the skin. Mole changes that may indicate melanoma include asymmetrical shape, an irregular border, change in color, and change in size (larger than ΒΌ inch diameter). Although melanoma generally occurs in places with a lot of sun exposure, it can also occur in other areas, especially in people with darker skin. This type of melanoma, called hidden melanoma, can occur under a nail, in the mouth, or on the bottom of the foot. The cause of melanoma is not completely clear, but it is likely due to a combination of environmental and genetic factors. UV radiation, from the sun or tanning beds, is considered the leading cause of melanoma. Risk factors include fair skin, a history of sunburn, excessive UV light exposure, living at high elevation, unusual number of moles, family history of melanoma, and a weakened immune system.

A doctor, usually a dermatologist, can identify signs of melanoma by examining the skin. Removal (biopsy) and examination under the microscope (pathology) of the affected area is used to confirm the diagnosis. Like many forms of cancer, there are many treatment options available. Early-stage melanomas are usually removed entirely during the biopsy and require no further treatment. Melanomas that have spread beyond the skin, to lymph nodes or other parts of the body, will need additional treatments which may include surgery to remove affected lymph nodes, chemotherapy or radiation therapy to destroy the cancer cells, biological therapy to boost the immune system, and targeted therapy. If you have been diagnosed with melanoma, speak with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

Last Updated: 29 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

http://www.melanomainternational.org

Last Updated: 29 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melanoma" returned 11104 free, full-text research articles on human participants. First 3 results:

Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells.
 

Author(s): Maotao Du, Zhong Zhang, Tao Gao

Journal:

 

Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions are few. Piceatannol, owns the similar function as resveratrol, has been ...

Last Updated: 18 Oct 2017

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Classifying dermoscopic patterns of naevi in a case-control study of melanoma.
 

Author(s): Seamus R McWhirter, David L Duffy, Katie J Lee, Glen Wimberley, Philip McClenahan, Natalie Ling, Marco Ardigo, Helmut Schaider, H Peter Soyer, Richard A Sturm

Journal:

 

Changes in dermoscopic patterns of naevi may be associated with melanoma; however, there is no consensus on which dermoscopic classification system is optimal. To determine whether different classification systems give comparable results and can be combined for analysis, we applied ...

Last Updated: 17 Oct 2017

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Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual.
 

Author(s): Jeffrey E Gershenwald, Richard A Scolyer, Kenneth R Hess, Vernon K Sondak, Georgina V Long, Merrick I Ross, Alexander J Lazar, Mark B Faries, John M Kirkwood, Grant A McArthur, Lauren E Haydu, Alexander M M Eggermont, Keith T Flaherty, Charles M Balch, John F Thompson,

Journal: CA Cancer J Clin. 2017 Nov;67(6):472-492.

 

Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses ...

Last Updated: 13 Oct 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melanoma" returned 889 free, full-text review articles on human participants. First 3 results:

Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma.
 

Author(s): Leslie Calapre, Lydia Warburton, Michael Millward, Mel Ziman, Elin S Gray

Journal: Cancer Lett.. 2017 Sep;404():62-69.

 

Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. In melanoma, ctDNA has been shown to have clinical value as an alternative tumour source for the detection clinically targetable mutations ...

Last Updated: 8 Jul 2017

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Efficacy and safety of anti-PD-1 and anti-PD-1 combined with anti-CTLA-4 immunotherapy to advanced melanoma: A systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Chunyan Hao, Jinhui Tian, Huiling Liu, Fei Li, Hongxia Niu, Bingdong Zhu

Journal: Medicine (Baltimore). 2017 Jun;96(26):e7325.

 

Anti-PD-1 monoclonal antibodies, nivolumab and pembrolizumab, and anti-CTLA-4 antibody ipilimumab are being in clinic trials to treat melanoma. Here, we performed a meta-analysis to evaluate the efficacy and toxicity of them against advanced melanoma.

Last Updated: 28 Jun 2017

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A long-term survivor with esophageal melanoma and pulmonary metastasis after single-stage esophagectomy and lobectomy: Case report and literature review.
 

Author(s): Tian Zhao, Feng-Wei Kong, Heng Wang, Dong Liu, Chun-Ying Wang, Jin-Hua Luo, Miao Zhang, Wen-Bin Wu

Journal: Medicine (Baltimore). 2017 May;96(21):e7003.

 

The optimal therapeutic regimen for primary malignant melanoma of the esophagus (PMME) need to be further elucidated. Besides, the efficacy of surgery for PMME with remote metastasis is uncertain for its rarity.

Last Updated: 24 May 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prospective Melanoma Database
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 25 Aug 2016

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Characterization of the Melanoma-Specific Immune Response
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 25 May 2017

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LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 13 Jul 2017

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