Melanoma

Common Name(s)

Melanoma

Melanoma is the most serious type of skin cancer that develops in cells that produce melanin (melanocytes), which give skin its color. Skin cancer is a life threatening condition, but it can be fully treated if detected early. Symptoms of melanoma include a change to an existing mole or the development of an abnormal growth on the skin. Mole changes that may indicate melanoma include asymmetrical shape, an irregular border, change in color, and change in size (larger than ¼ inch diameter). Although melanoma generally occurs in places with a lot of sun exposure, it can also occur in other areas, especially in people with darker skin. This type of melanoma, called hidden melanoma, can occur under a nail, in the mouth, or on the bottom of the foot. The cause of melanoma is not completely clear, but it is likely due to a combination of environmental and genetic factors. UV radiation, from the sun or tanning beds, is considered the leading cause of melanoma. Risk factors include fair skin, a history of sunburn, excessive UV light exposure, living at high elevation, unusual number of moles, family history of melanoma, and a weakened immune system.

A doctor, usually a dermatologist, can identify signs of melanoma by examining the skin. Removal (biopsy) and examination under the microscope (pathology) of the affected area is used to confirm the diagnosis. Like many forms of cancer, there are many treatment options available. Early-stage melanomas are usually removed entirely during the biopsy and require no further treatment. Melanomas that have spread beyond the skin, to lymph nodes or other parts of the body, will need additional treatments which may include surgery to remove affected lymph nodes, chemotherapy or radiation therapy to destroy the cancer cells, biological therapy to boost the immune system, and targeted therapy. If you have been diagnosed with melanoma, speak with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

Last Updated: 29 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

http://www.melanomainternational.org

Last Updated: 29 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melanoma" returned 11522 free, full-text research articles on human participants. First 3 results:

Implication of Integrin α2β1 in Proliferation and Invasion of Human Breast Carcinoma and Melanoma Cells: Noncanonical Function of Akt Protein Kinase.
 

Author(s): N I Kozlova, G E Morozevich, N A Ushakova, A E Berman

Journal: Biochemistry Mosc.. 2018 Jun;83(6):738-745.

 

Blocking the expression of integrin α2β1, which was accomplished by transduction of α2-specific shRNA, resulted in significant inhibition of proliferation and clonal activity in human MCF-7 breast carcinoma and SK-Mel-147 melanoma cells. Along with these changes, deprivation of ...

Last Updated: 31 Dec 1969

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Iris Melanoma in a Child Simulating Juvenile Xanthogranuloma.
 

Author(s): Jerry A Shields, Carol L Shields, Sara E Lally, Tatyana Milman, Ralph C Eagle

Journal: Middle East Afr J Ophthalmol. ;25(2):115-117.

 

An 8-year-old girl was referred for an amelanotic iris tumor believed to have enlarged slightly over 3 months, suspicious for juvenile xanthogranuloma (JXG). The affected right eye had a lightly pigmented, vascular iris mass measuring 6 mm in basal dimension and 2 mm in thickness. ...

Last Updated: 31 Dec 1969

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Outcome Analysis of Visual Acuity and Side Effect after Ruthenium-106 Plaque Brachytherapy for Medium-sized Choroidal Melanoma.
 

Author(s): Tahra AlMahmoud, Sean Quinlan-Davidson, Gregory R Pond, Jean Deschênes

Journal: Middle East Afr J Ophthalmol. ;25(2):103-107.

 

The purpose of this study is to report on treatment outcomes for medium-sized choroidal melanoma treated with Ruthenium-106 (Ru-106) plaque brachytherapy.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melanoma" returned 971 free, full-text review articles on human participants. First 3 results:

Choroidal Melanoma Resection.
 

Author(s): Hany S Hamza, Abdelrahman M Elhusseiny

Journal: Middle East Afr J Ophthalmol. ;25(2):65-70.

 

Uveal melanoma is the most common intraocular malignant tumor, with the choroid being the most common site. Management of choroidal melanoma has evolved greatly over the past years. In the past, the conventional method of treatment was enucleation of the affected eye with a debate ...

Last Updated: 31 Dec 1969

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Direct costs associated with adverse events of systemic therapies for advanced melanoma: Systematic literature review.
 

Author(s): Catherine Copley-Merriman, Kendall Stevinson, Frank Xiaoqing Liu, Jingshu Wang, Josephine Mauskopf, Evelina A Zimovetz, Bartosz Chmielowski

Journal: Medicine (Baltimore). 2018 Aug;97(31):e11736.

 

Treatments for advanced melanoma are associated with different adverse events (AEs), which may be costly to manage. This study aimed to evaluate direct costs associated with managing treatment-related AEs for advanced melanoma through a systematic literature review.

Last Updated: 31 Dec 1969

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Complete lymphadenectomy following positive sentinel lymph node biopsy in cutaneous melanoma: a critical review.
 

Author(s): Daniel Eiger, Daniel Arcuschin de Oliveira, Renato Leão de Oliveira, Murilo Costa Sousa, Mireille Darc Cavalcante Brandão, Renato Santos de Oliveira Filho

Journal: An Bras Dermatol. ;93(4):553-558.

 

Cutaneous melanoma is the solid neoplasia with the highest growing incidence among all tumors. It spreads predictably to the lymphatic vessels and sentinel lymph node, and when the latter is affected the prognosis worsens dramatically. Sentinel lymph node biopsy is considered when ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prospective Melanoma Database
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 25 Aug 2016

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MCS110 With BRAF/MEK Inhibition in Patients With Melanoma
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 2 Aug 2018

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LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 8 Aug 2018

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