Melanoma

Common Name(s)

Melanoma

Melanoma is the most serious type of skin cancer that develops in cells that produce melanin (melanocytes), which give skin its color. Skin cancer is a life threatening condition, but it can be fully treated if detected early. Symptoms of melanoma include a change to an existing mole or the development of an abnormal growth on the skin. Mole changes that may indicate melanoma include asymmetrical shape, an irregular border, change in color, and change in size (larger than ¼ inch diameter). Although melanoma generally occurs in places with a lot of sun exposure, it can also occur in other areas, especially in people with darker skin. This type of melanoma, called hidden melanoma, can occur under a nail, in the mouth, or on the bottom of the foot. The cause of melanoma is not completely clear, but it is likely due to a combination of environmental and genetic factors. UV radiation, from the sun or tanning beds, is considered the leading cause of melanoma. Risk factors include fair skin, a history of sunburn, excessive UV light exposure, living at high elevation, unusual number of moles, family history of melanoma, and a weakened immune system.

A doctor, usually a dermatologist, can identify signs of melanoma by examining the skin. Removal (biopsy) and examination under the microscope (pathology) of the affected area is used to confirm the diagnosis. Like many forms of cancer, there are many treatment options available. Early-stage melanomas are usually removed entirely during the biopsy and require no further treatment. Melanomas that have spread beyond the skin, to lymph nodes or other parts of the body, will need additional treatments which may include surgery to remove affected lymph nodes, chemotherapy or radiation therapy to destroy the cancer cells, biological therapy to boost the immune system, and targeted therapy. If you have been diagnosed with melanoma, speak with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

Last Updated: 29 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

http://www.melanomainternational.org

Last Updated: 29 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melanoma" returned 11257 free, full-text research articles on human participants. First 3 results:

Diphencyprone as a therapeutic option in cutaneous metastasis of melanoma. A single-institution experience.
 

Author(s): Ivana Lameiras Gibbons, Marina Sonagli, Eduardo Bertolli, Mariana Petaccia de Macedo, Clovis Antonio Lopes Pinto, João Pedreira Duprat Neto

Journal: An Bras Dermatol. 2018 Mar;93(2):299-301.

 

Diphencyprone has been reported as a local immunotherapy for cutaneous melanoma metastases. We aim to report cases of melanoma patients treated with diphencyprone in a single Brazilian institution and highlight their outcomes. Since 2012, we have treated 16 melanoma patients with ...

Last Updated: 31 Dec 1969

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Surgical management of tumor-positive interval node in melanoma patients: An observational study.
 

Author(s): Eleonora Nacchiero, Michelangelo Vestita, Fabio Robusto, Michele Maruccia, Paolo Annoscia, Giuseppe Giudice

Journal: Medicine (Baltimore). 2018 May;97(18):e0584.

 

The presence of interval nodes (IN) in melanoma is testified in several studies and sometimes these lymph nodes can contain metastatic disease. Currently there are no guidelines about the management of patients with tumor-positive INs.We enrolled all patients affected by melanoma ...

Last Updated: 31 Dec 1969

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More on Adjuvant Therapy in Resected Melanoma.
 

Author(s): Mark B Faries, Stacey Stern, John F Thompson

Journal: N. Engl. J. Med.. 2018 04;378(17):1656-1657.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melanoma" returned 937 free, full-text review articles on human participants. First 3 results:

Are phosphodiesterase type 5 inhibitors associated with increased risk of melanoma?: A systematic review and meta-analysis.
 

Author(s): Shijian Feng, Liang Zhou, Qinyu Liu, Qing He, Banghua Liao, Xin Wei, Hong Li, Kunjie Wang, Yuchun Zhu

Journal: Medicine (Baltimore). 2018 Jan;97(3):e9601.

 

Phosphodiesterase type 5 (PDE5) inhibitors are recommended for patients with erectile dysfunction by American Urological Association and European Association Urology guidelines. However, recent researches have shown that PDE5 inhibitors may lead to increased melanoma risk. Thus, we ...

Last Updated: 31 Dec 1969

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ECCO essential requirements for quality cancer care: Melanoma.
 

Author(s): Michel W Wouters, Olivier Michielin, Esther Bastiaannet, Marc Beishon, Orlando Catalano, Veronique Del Marmol, Roberto Delgado-Bolton, Rémi Dendale, Maria Die Trill, Andrea Ferrari, Ana-Maria Forsea, Hannelore Kreckel, József Lövey, Gre Luyten, Daniela Massi, Peter Mohr, Simon Oberst, Philippe Pereira, João Paulo Paiva Prata, Piotr Rutkowski, Tiina Saarto, Sapna Sheth, Gilly Spurrier-Bernard, Meri-Sisko Vuoristo, Alberto Costa, Peter Naredi

Journal: Crit. Rev. Oncol. Hematol.. 2018 Feb;122():164-178.

 

ECCO essential requirements for quality cancer care (ERQCC) are explanations and descriptions of challenges, organisation and actions that are necessary to give high-quality care to patients who have a specific type of cancer. They are written by European experts representing all ...

Last Updated: 31 Dec 1969

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Brain metastasis in a patient with melanoma receiving Pembrolizumab therapy: A case report and review of the literature.
 

Author(s): Jin-Cheng Song, Xiao-Lei Ding, Xiu-Hua Sun, Mohammed Safi, Juan Tian

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9278.

 

Melanoma with brain metastasis is associated with a poor prognosis and high mortality rate. As patients with this condition have been excluded from most clinical trials, data on the use of anti-programmed death 1 therapy for these patients are limited.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prospective Melanoma Database
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 25 Aug 2016

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MCS110 With BRAF/MEK Inhibition in Patients With Melanoma
 

Status: Not yet recruiting

Condition Summary: Melanoma

 

Last Updated: 8 Mar 2018

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LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 31 Jan 2018

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