Melanoma

Common Name(s)

Melanoma

Melanoma is the most serious type of skin cancer that develops in cells that produce melanin (melanocytes), which give skin its color. Skin cancer is a life threatening condition, but it can be fully treated if detected early. Symptoms of melanoma include a change to an existing mole or the development of an abnormal growth on the skin. Mole changes that may indicate melanoma include asymmetrical shape, an irregular border, change in color, and change in size (larger than ¼ inch diameter). Although melanoma generally occurs in places with a lot of sun exposure, it can also occur in other areas, especially in people with darker skin. This type of melanoma, called hidden melanoma, can occur under a nail, in the mouth, or on the bottom of the foot. The cause of melanoma is not completely clear, but it is likely due to a combination of environmental and genetic factors. UV radiation, from the sun or tanning beds, is considered the leading cause of melanoma. Risk factors include fair skin, a history of sunburn, excessive UV light exposure, living at high elevation, unusual number of moles, family history of melanoma, and a weakened immune system.

A doctor, usually a dermatologist, can identify signs of melanoma by examining the skin. Removal (biopsy) and examination under the microscope (pathology) of the affected area is used to confirm the diagnosis. Like many forms of cancer, there are many treatment options available. Early-stage melanomas are usually removed entirely during the biopsy and require no further treatment. Melanomas that have spread beyond the skin, to lymph nodes or other parts of the body, will need additional treatments which may include surgery to remove affected lymph nodes, chemotherapy or radiation therapy to destroy the cancer cells, biological therapy to boost the immune system, and targeted therapy. If you have been diagnosed with melanoma, speak with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

Last Updated: 29 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

http://www.melanomainternational.org

Last Updated: 29 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melanoma" returned 10804 free, full-text research articles on human participants. First 3 results:

Glomerulonephritis and granulomatous vasculitis in kidney as a complication of the use of BRAF and MEK inhibitors in the treatment of metastatic melanoma: A case report.
 

Author(s): Mehdi Maanaoui, Camille Saint-Jacques, Viviane Gnemmi, Marie Frimat, Arnaud Lionet, Marc Hazzan, Christian Noël, François Provot

Journal: Medicine (Baltimore). 2017 Jun;96(25):e7196.

 

BRAF and MEK inhibitors have significantly improved the prognosis of metastatic melanoma, by inhibiting both the mitogen-activated protein kinase (MAP-kinase) pathway. They are associated with infrequent adverse kidney events. Most of these are related to the use of BRAF inhibitors ...

Last Updated: 22 Jun 2017

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Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3.
 

Author(s): Robert M Duvoisin, Tammie L Haley, Gaoying Ren, Iwona Strycharska-Orczyk, James P Bonaparte, Catherine W Morgans

Journal: Invest. Ophthalmol. Vis. Sci.. 2017 05;58(5):2732-2738.

 

Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome associated with malignant melanoma and the presence of anti-retinal autoantibodies, including autoantibodies against transient receptor potential melanopsin 1 (TRPM1), a cation channel expressed by both melanocytes ...

Last Updated: 26 May 2017

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Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma.
 

Author(s): Bettina Hieronimus, Julian Pfohl, Christian Busch, Lutz Graeve

Journal: Cell. Physiol. Biochem.. 2017 ;42(1):198-210.

 

Membrane-type matrix metalloproteinases (MT-MMPs) are expressed on the cell surface and hydrolyze extracellular matrix components and signaling molecules by which they influence cancer cell migration and metastasis. Two of the six known MT-MMPs are anchored to the plasma membrane ...

Last Updated: 22 May 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melanoma" returned 857 free, full-text review articles on human participants. First 3 results:

Efficacy and safety of anti-PD-1 and anti-PD-1 combined with anti-CTLA-4 immunotherapy to advanced melanoma: A systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Chunyan Hao, Jinhui Tian, Huiling Liu, Fei Li, Hongxia Niu, Bingdong Zhu

Journal: Medicine (Baltimore). 2017 Jun;96(26):e7325.

 

Anti-PD-1 monoclonal antibodies, nivolumab and pembrolizumab, and anti-CTLA-4 antibody ipilimumab are being in clinic trials to treat melanoma. Here, we performed a meta-analysis to evaluate the efficacy and toxicity of them against advanced melanoma.

Last Updated: 28 Jun 2017

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A long-term survivor with esophageal melanoma and pulmonary metastasis after single-stage esophagectomy and lobectomy: Case report and literature review.
 

Author(s): Tian Zhao, Feng-Wei Kong, Heng Wang, Dong Liu, Chun-Ying Wang, Jin-Hua Luo, Miao Zhang, Wen-Bin Wu

Journal: Medicine (Baltimore). 2017 May;96(21):e7003.

 

The optimal therapeutic regimen for primary malignant melanoma of the esophagus (PMME) need to be further elucidated. Besides, the efficacy of surgery for PMME with remote metastasis is uncertain for its rarity.

Last Updated: 24 May 2017

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Progressive visual disturbance and enlarging prolactinoma caused by melanoma metastasis: A case report and literature review.
 

Author(s): Chuanwei Yang, Ling Liu, Xiaoqiang Lan, Shiqiang Zhang, Xinyu Li, Bo Zhang

Journal: Medicine (Baltimore). 2017 Apr;96(14):e6483.

 

Melanoma metastases to the pituitary adenoma (MMPA) are extremely rare, with only 1 reported case. To date, the melanoma metastasis to the existing prolactinoma has not been reported in literatures.

Last Updated: 6 Apr 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prospective Melanoma Database
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 25 Aug 2016

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Characterization of the Melanoma-Specific Immune Response
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 25 May 2017

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LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 13 Jul 2017

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