Melanoma

Common Name(s)

Melanoma

Melanoma is the most serious type of skin cancer that develops in cells that produce melanin (melanocytes), which give skin its color. Skin cancer is a life threatening condition, but it can be fully treated if detected early. Symptoms of melanoma include a change to an existing mole or the development of an abnormal growth on the skin. Mole changes that may indicate melanoma include asymmetrical shape, an irregular border, change in color, and change in size (larger than ¼ inch diameter). Although melanoma generally occurs in places with a lot of sun exposure, it can also occur in other areas, especially in people with darker skin. This type of melanoma, called hidden melanoma, can occur under a nail, in the mouth, or on the bottom of the foot. The cause of melanoma is not completely clear, but it is likely due to a combination of environmental and genetic factors. UV radiation, from the sun or tanning beds, is considered the leading cause of melanoma. Risk factors include fair skin, a history of sunburn, excessive UV light exposure, living at high elevation, unusual number of moles, family history of melanoma, and a weakened immune system.

A doctor, usually a dermatologist, can identify signs of melanoma by examining the skin. Removal (biopsy) and examination under the microscope (pathology) of the affected area is used to confirm the diagnosis. Like many forms of cancer, there are many treatment options available. Early-stage melanomas are usually removed entirely during the biopsy and require no further treatment. Melanomas that have spread beyond the skin, to lymph nodes or other parts of the body, will need additional treatments which may include surgery to remove affected lymph nodes, chemotherapy or radiation therapy to destroy the cancer cells, biological therapy to boost the immune system, and targeted therapy. If you have been diagnosed with melanoma, speak with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

View Details
Logo
Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

Last Updated: 29 Jun 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melanoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Logo
Melanoma International Foundation

The mission of the Melanoma International Foundation is to develop personalized strategies with patients so they may live longer, better lives.

http://www.melanomainternational.org

Last Updated: 29 Jun 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melanoma" returned 11303 free, full-text research articles on human participants. First 3 results:

The significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases: The implications for BRAF inhibitor therapy.
 

Author(s): Enda J Hannan, Donal P O'Leary, Stephen P MacNally, Elaine W Kay, Michael A Farrell, Patrick G Morris, Colm P Power, Arnold D K Hill

Journal: Medicine (Baltimore). 2017 Dec;96(48):e8404.

 

To compare BRAF V600E status of primary melanoma and brain metastases to assess for discordance by cross-sectional study, and to evaluate clinical implications on BRAF inhibitor therapy.Brain metastases are common in patients with advanced melanoma. Between 40% and 60% of melanomas ...

Last Updated: 31 Dec 1969

Go To URL
Comparison of computer systems and ranking criteria for automatic melanoma detection in dermoscopic images.
 

Author(s): Kajsa Møllersen, Maciel Zortea, Thomas R Schopf, Herbert Kirchesch, Fred Godtliebsen

Journal:

 

Melanoma is the deadliest form of skin cancer, and early detection is crucial for patient survival. Computer systems can assist in melanoma detection, but are not widespread in clinical practice. In 2016, an open challenge in classification of dermoscopic images of skin lesions was ...

Last Updated: 31 Dec 1969

Go To URL
Melanoma Metastatic to the Duodenum.
 

Author(s): Themistoklis Kourkoumpetis, Maria E Jarbrink-Sehgal

Journal: N. Engl. J. Med.. 2017 Dec;377(25):e34.

 

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melanoma" returned 904 free, full-text review articles on human participants. First 3 results:

Primary malignant melanoma of the lung: A case report and literature review.
 

Author(s): Juan Peng, Fengfeng Han, Tianyun Yang, Jinyuan Sun, Wenbin Guan, Xuejun Guo

Journal: Medicine (Baltimore). 2017 Nov;96(46):e8772.

 

Primary malignant melanoma of the lung (PMML) is an extremely rare neoplasm with a dismal prognosis. The diagnosis of PMML is very difficult and is based on several clinical, radiological, and histopathological criteria.

Last Updated: 31 Dec 1969

Go To URL
Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma.
 

Author(s): Leslie Calapre, Lydia Warburton, Michael Millward, Mel Ziman, Elin S Gray

Journal: Cancer Lett.. 2017 Sep;404():62-69.

 

Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. In melanoma, ctDNA has been shown to have clinical value as an alternative tumour source for the detection clinically targetable mutations ...

Last Updated: 31 Dec 1969

Go To URL
Efficacy and safety of anti-PD-1 and anti-PD-1 combined with anti-CTLA-4 immunotherapy to advanced melanoma: A systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Chunyan Hao, Jinhui Tian, Huiling Liu, Fei Li, Hongxia Niu, Bingdong Zhu

Journal: Medicine (Baltimore). 2017 Jun;96(26):e7325.

 

Anti-PD-1 monoclonal antibodies, nivolumab and pembrolizumab, and anti-CTLA-4 antibody ipilimumab are being in clinic trials to treat melanoma. Here, we performed a meta-analysis to evaluate the efficacy and toxicity of them against advanced melanoma.

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Prospective Melanoma Database
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 25 Aug 2016

Go to URL
LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma
 

Status: Recruiting

Condition Summary: Melanoma

 

Last Updated: 13 Jul 2017

Go to URL