Melioidosis

Common Name(s)

Melioidosis, Whitmore's disease

Melioidosis is an infectious disease caused by a bacteria found in contaminated soil and water. It is a disease that is especially common in Thailand and northern Australia, but also problematic in tropical areas such as the South Pacific, Africa or India. The bacteria linked with melioidosis is found in soil, rice paddies, or still waters in these areas. A person may become infected by inhaling contaminated dust or water particles, by drinking contaminated water, or by having contaminated soil or water enter the body through an open wound or scratch. Person-to-person spread of the disease is rare.

Common symptoms of melioidosis may include shortness of breath, cough, and fever. Additionally, the condition may cause a variety of breathing illnesses from mild bronchitis, or more seriously, pneumonia. A skin infection may develop if an opening in the skin is contaminated. This area can then swell and form an ulcer (sore) or an abscess (pus buildup under the skin). In more severe cases of melioidosis, symptoms may also include weight loss, disorientation, or seizures. Melioidosis symptoms are usually noticed within two to four weeks after infection, but can show up as early as the day after to as late as many years after. Diagnosis is usually made by examining blood and urine samples.

Individuals with other preexisting conditions that weaken the immune system, such as diabetes or AIDS, are more likely to get infected. These individuals should avoid soil and water in tropical farm areas that may have been contaminated with the bacteria. If left untreated, melioidosis can be fatal. However, this disease is treatable with medication. Therefore, if you believe you have melioidosis, contact your doctor so you may begin treatment as soon as possible.

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Condition Specific Organizations

Following organizations serve the condition "Melioidosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melioidosis" returned 320 free, full-text research articles on human participants. First 3 results:

Notes from the Field: Travel-Associated Melioidosis and Resulting Laboratory Exposures - United States, 2016.
 

Author(s): Patrick K Mitchell, Colin Campbell, Martha P Montgomery, Julie Paoline, Christopher Wilbur, Leah Posivak-Khouly, Kristin Garafalo, Mindy Elrod, Lindy Liu, Andre Weltman

Journal:

 

In mid-July 2016, a Pennsylvania resident aged 15 years who had recently returned from Thailand was treated by a pediatrician for sore throat, fever, and bilateral thigh abscesses at the sites of mosquito bites (Figure). She had traveled to northeast Thailand with nine other teens ...

Last Updated: 21 Sep 2017

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Melioidosis in lower provincial Cambodia: A case series from a prospective study of sepsis in Takeo Province.
 

Author(s): Kevin L Schully, Catherine M Berjohn, Angela M Prouty, Amitha Fitkariwala, Tin Som, Darith Sieng, Michael J Gregory, Andrew Vaughn, Sim Kheng, Vantha Te, Christopher A Duplessis, James V Lawler, Danielle V Clark

Journal:

 

Melioidosis is a severe infectious disease caused by the gram-negative soil bacterium Burkholderia pseudomallei. Melioidosis is well known to be a major cause of morbidity and mortality in Southeast Asia, particularly in Thailand. However, melioidosis remains underreported in surrounding ...

Last Updated: 13 Sep 2017

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A case report of co-infection of Melioidosis and cutaneous Leishmaniasis.
 

Author(s): Isuru Chamika Indeewara Kahandawaarachchi, Gayani Samadara Premawansa, Wipula Warnasuriya, Malka Dassanayake, Enoka Corea

Journal:

 

Leishmaniasis and melioidosis are frequently reported from the North Central Province of Sri Lanka. However, only one case of co-infection of the two diseases has been reported to date over the world. This is a case report of a patient who had co-infection with cutaneous leishmaniasis ...

Last Updated: 2 Aug 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melioidosis" returned 27 free, full-text review articles on human participants. First 3 results:

Melioidosis: Clinical impact and public health threat in the tropics.
 

Author(s): Ramar Perumal Samy, Bradley G Stiles, Gautam Sethi, Lina H K Lim

Journal:

 

This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in Singapore, Malaysia, Thailand, Vietnam, ...

Last Updated: 11 May 2017

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Melioidosis in Malaysia: A Review of Case Reports.
 

Author(s): Paul Vijay Kingsley, Mark Leader, Nandika Suranjith Nagodawithana, Meghan Tipre, Nalini Sathiakumar

Journal:

 

Melioidosis is a tropical infectious disease associated with significant mortality due to early onset of sepsis.

Last Updated: 22 Dec 2016

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The epidemiology and clinical spectrum of melioidosis in a teaching hospital in a North-Eastern state of Malaysia: a fifteen-year review.
 

Author(s): AbdelRahman Zueter, Chan Yean Yean, Mahmoud Abumarzouq, Zaidah Abdul Rahman, Zakuan Z Deris, Azian Harun

Journal:

 

Over the last two decades, many epidemiological studies were performed to describe risks and clinical presentations of melioidosis in endemic countries.

Last Updated: 18 Jul 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical Presentation of Melioidosis in Head and Neck Region
 

Status: Recruiting

Condition Summary: Melioidosis; Head and Neck Infection

 

Last Updated: 8 Feb 2017

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Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis
 

Status: Recruiting

Condition Summary: Melioidosis; Systemic Inflammatory Response Syndrome; Suspected or Confirmed Bloodstream Infections

 

Last Updated: 13 Jun 2017

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