Melorheostosis

Common Name(s)

Melorheostosis

Melorheostosis is a progressive skeletal disorder that causes bones to thicken. This condition can also affect joints, soft tissue, and skin. Melorheostosis can cause pain, stiffness, limited movement, and limb deformities, although some individuals do not have any symptoms. Mutations in the LEMD3 gene have been found to cause melorheostosis. Treatment options include surgery, physical and occupational therapy, hydrotherapy, and medications.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melorheostosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melorheostosis" returned 28 free, full-text research articles on human participants. First 3 results:

Melorheostosis: Exome sequencing of an associated dermatosis implicates postzygotic mosaicism of mutated KRAS.
 

Author(s): Michael P Whyte, Malachi Griffith, Lee Trani, Steven Mumm, Gary S Gottesman, William H McAlister, Kilannin Krysiak, Robert Lesurf, Zachary L Skidmore, Katie M Campbell, Ilana S Rosman, Susan Bayliss, Vinieth N Bijanki, Angela Nenninger, Brian A Van Tine, Obi L Griffith, Elaine R Mardis

Journal: Bone. 2017 Aug;101():145-155.

 

Melorheostosis (MEL) is the rare sporadic dysostosis characterized by monostotic or polyostotic osteosclerosis and hyperostosis often distributed in a sclerotomal pattern. The prevailing hypothesis for MEL invokes postzygotic mosaicism. Sometimes scleroderma-like skin changes, considered ...

Last Updated: 31 Dec 1969

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18F-NaF PET/CT in Extensive Melorheostosis of the Axial and Appendicular Skeleton With Soft-Tissue Involvement.
 

Author(s): Georgios Z Papadakis, Smita Jha, Timothy Bhattacharyya, Corina Millo, Tsang-Wei Tu, Ulas Bagci, Kostas Marias, Apostolos H Karantanas, Nicholas J Patronas

Journal: Clin Nucl Med. 2017 Jul;42(7):537-539.

 

Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement. We report on a patient with extensive ...

Last Updated: 31 Dec 1969

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Melorheostosis mimicking synovial osteochondromatosis.
 

Author(s): Vibhor Wadhwa, Avneesh Chhabra, Jonathan D Samet

Journal: Ann Saudi Med. ;34(6):547-50.

 

Melorheostosis is an uncommon, sporadic, sclerosing bone lesion that may affect the adjacent soft tissues. It has been associated with many entities such as osteopoikilosis, soft tissue vascular malformations, bone and soft tissue tumors, nephrotic syndrome, segmental limb contractures, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melorheostosis" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease
 

Status: Recruiting

Condition Summary: Rheumatic Disease

 

Last Updated: 8 Aug 2018

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