Membranoproliferative glomerulonephritis type 2

Common Name(s)

Membranoproliferative glomerulonephritis type 2

Dense deposit disease (DDD) is a condition that primarily affects kidney function. Signs and symptoms usually start between the ages of 5 and 15 but may also begin in adulthood. The major features of DDD are due to kidney malfunction, and often include proteinuria; hematuria; reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. About half of affected people develop end-stage renal disease (ESRD) within 10 years after symptoms start. DDD can have genetic or non-genetic causes. It can be caused by mutations in the C3 and CFH genes; it may develop as a result of both genetic risk factors and environmental triggers; or it can result from the presence of autoantibodies that block the activity of proteins needed for the body's immune response. Most cases are sporadic (occurring by chance in people with no history of the disorder in their family).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranoproliferative glomerulonephritis type 2" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Membranoproliferative glomerulonephritis type 2" returned 1 free, full-text research articles on human participants. First 3 results:

High-speed ultrahigh-resolution OCT of Bruch's membrane in membranoproliferative glomerulonephritis type 2.
 

Author(s): Mehreen Adhi, Sarah P Read, Jonathan J Liu, James G Fujimoto, Jay S Duker

Journal: Ophthalmic Surg Lasers Imaging Retina. ;45(6):614-7.

 

Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to ...

Last Updated: 26 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Membranoproliferative glomerulonephritis type 2" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety Study of IgAN, LN, MN, & C3 Glomerulopathy Including Dense Deposit Disease Treated With OMS721
 

Status: Recruiting

Condition Summary: IgAN; Lupus Nephritis; MN; C3G

 

Last Updated: 3 Mar 2017

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