Membranous nephropathy

Common Name(s)

Membranous nephropathy

Membranous nephropathy is a kidney disease characterized by inflammation of the structures inside the kidney that help filter wastes and fluids. When the glomerular basement membrane becomes thickened, it does not work normally, allowing large amounts of protein to be lost in the urine. Symptoms develop gradually and may include swelling, fatigue, weight gain, and high blood pressure. In many cases, the underlying cause of membranous nephropathy is not known. Some cases are associated with other conditions (lupus), infections (hepatitis B and C), cancer or as a side effect of certain medications. The goal of treatment is to reduce symptoms and slow the progression of the disease.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranous nephropathy" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Membranous nephropathy" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Membranous nephropathy" returned 311 free, full-text research articles on human participants. First 3 results:

Membranous nephropathy in a patient with ankylosing spondylitis: A case report.
 

Author(s): Ruiying Chen, Fang Li, Qionghong Xie, Jun Xue, Lingyun Lai, Shaojun Liu, Liyin Zhang, Chuanming Hao

Journal: Medicine (Baltimore). 2017 Oct;96(43):e8201.

 

Renal complications in ankylosing spondylitis (AS) were rarely observed, and proteinuria associated with AS can be seen often due to amyloidosis in this kind of complications, while membranous nephropathy (MN) is seldom considered. This article reports a case of coexistence of AS ...

Last Updated: 25 Oct 2017

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Comparative effectiveness and tolerance of immunosuppressive treatments for idiopathic membranous nephropathy: A network meta-analysis.
 

Author(s): Song Ren, Ying Wang, Li Xian, Tadashi Toyama, Meg Jardine, Guisen Li, Vlado Perkovic, Daqing Hong

Journal:

 

Immunosuppressive agents in general are shown to prevent renal progression and all-cause mortality in idiopathic membranous nephropathy (IMN) patients with nephrotic syndrome. However, the efficacy and safety of different immunosuppressive treatments have not been systematic assessed ...

Last Updated: 12 Sep 2017

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Serum anti-PLA2R antibody and glomerular PLA2R deposition in Chinese patients with membranous nephropathy: A cross-sectional study.
 

Author(s): Lu Pang, Ai-Min Zhang, Hai-Xia Li, Jia-Lin Du, Li-Li Jiao, Nan Duan, Yi Liu, Dan Yu

Journal: Medicine (Baltimore). 2017 Jun;96(24):e7218.

 

M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary membranous nephropathy (PMN). Previous studies have evaluated the diagnostic value of serum anti-PLA2R antibody. However, the correlation of serum anti-PLA2R antibody and glomerular PLA2R deposition, and ...

Last Updated: 14 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Membranous nephropathy" returned 44 free, full-text review articles on human participants. First 3 results:

Membranous nephropathy associated with hepatitis C virus infection treated with corticosteroids and Ledipasvir-Sofosbuvir: a case report and review of literature.
 

Author(s): Qinjie Weng, Xiao Li, Hong Ren, Jingyuan Xie, Xiaoxia Pan, Jing Xu, Nan Chen

Journal: Oncotarget. 2017 Mar;8(13):22299-22303.

 

Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults. As many clinical cases have reported, it may be associated with hepatitis C virus (HCV) infection. Antiviral therapy can be various.

Last Updated: 22 Feb 2017

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Rituximab in Membranous Nephropathy: Not All Studies Are Created Equal.
 

Author(s): Paolo Cravedi

Journal: Nephron. 2017 ;135(1):46-50.

 

Many prospective studies and a recent randomized controlled trial have shown that the B-cell-depleting monoclonal antibody, rituximab, safely promotes the remission of nephrotic syndrome in approximately 65% of patients with membranous nephropathy (MN). Mechanistic studies have indicated ...

Last Updated: 27 Sep 2016

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Membranous Nephropathy with an Enhanced Granular Expression of Thrombospondin Type-1 Domain-containing 7A in a Pregnant Woman.
 

Author(s): Takamasa Iwakura, Yoshihide Fujigaki, Naoko Katahashi, Taichi Sato, Sayaka Ishigaki, Naoko Tsuji, Yoshitaka Naito, Shinsuke Isobe, Masashi Ono, Yukitoshi Sakao, Takayuki Tsuji, Naro Ohashi, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda

Journal: Intern. Med.. ;55(18):2663-8.

 

A 30-year-old woman with proteinuria first noted at 26 weeks of gestation was admitted to undergo further evaluation. A renal biopsy revealed membranous nephropathy (MN). There was no evidence of any secondary MN. Prednisolone was initiated 6 months after delivery. Four months later, ...

Last Updated: 16 Sep 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Adrenocorticotropic Hormone in Membranous Nephropathy
 

Status: Recruiting

Condition Summary: Membranous Nephropathy

 

Last Updated: 17 Aug 2017

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Sequential Therapy With Tacrolimus and Rituximab in Primary Membranous Nephropathy
 

Status: Recruiting

Condition Summary: MEMBRANOUS NEPHROPATHY

 

Last Updated: 18 Aug 2016

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Peptide GAM Immunoadsorption Therapy in Autoimmune Membranous Nephropathy
 

Status: Recruiting

Condition Summary: Autoimmune Membranous Nephropathy

 

Last Updated: 16 Aug 2017

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