Merkel cell cancer

Common Name(s)

Merkel cell cancer

Merkel cell carcinoma (MCC) is a rare type of skin cancer that usually appears as a single, painless, lump on sun-exposed skin. It is typically red or violet in color. It is considered fast-growing and can spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body. Merkel cell polyomavirus has been detected in about 80% of the tumors tested. It is thought that this virus can cause somatic mutations leading to MCC when the immune system is weakened. Other risk factors for developing MCC include ultraviolet radiation and being over 50 years of age. Treatment should begin early and depends on the location and size of the cancer, and the extent to which it has spread.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Merkel cell cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Merkel cell cancer" returned 16 free, full-text research articles on human participants. First 3 results:

Clinical and prognostic significance of Merkel cell polyomavirus in nonsmall cell lung cancer.
 

Author(s): Gun-Jik Kim, Jae-Ho Lee, Deok Heon Lee

Journal: Medicine (Baltimore). 2017 Jan;96(3):e5413.

 

Recently, an association between Merkel cell polyomavirus (MCPyV) and epidermal growth factor receptor (EGFR) mutations in nonsmall cell lung cancer (NSCLC) was reported. However, the underlying carcinogenic effects and the prognosis related to MCPyV are still unclear. The aim of ...

Last Updated: 18 Jan 2017

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Recommendations for Solid Organ Transplantation for Transplant Candidates With a Pretransplant Diagnosis of Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma and Melanoma: A Consensus Opinion From the International Transplant Skin Cancer Collaborative (ITSCC).
 

Author(s): F Zwald, J Leitenberger, N Zeitouni, S Soon, J Brewer, S Arron, J Bordeaux, C Chung, M Abdelmalek, E Billingsley, A Vidimos, T Stasko

Journal: Am. J. Transplant.. 2016 Feb;16(2):407-13.

 

Advancements in solid organ transplantation successfully extend the lives of thousands of patients annually. The tenet of organ stewardship aims to prevent the futile expenditure of scarce donor organs in patient populations with high mortality risk, to the detriment of potential ...

Last Updated: 30 Jan 2016

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Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model.
 

Author(s): Masahiro Shuda, Anna Guastafierro, Xuehui Geng, Yoko Shuda, Stephen M Ostrowski, Stefan Lukianov, Frank J Jenkins, Kord Honda, Stephen M Maricich, Patrick S Moore, Yuan Chang

Journal:

 

Merkel cell polyomavirus (MCV) causes the majority of human Merkel cell carcinomas (MCC) and encodes a small T (sT) antigen that transforms immortalized rodent fibroblasts in vitro. To develop a mouse model for MCV sT-induced carcinogenesis, we generated transgenic mice with a flox-stop-flox ...

Last Updated: 7 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Merkel cell cancer" returned 3 free, full-text review articles on human participants. First 3 results:

The role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancer.
 

Author(s): Ugo Moens, Kashif Rasheed, Ibrahim Abdulsalam, Baldur Sveinbj├Şrnsson

Journal:

 

Polyomaviruses are non-enveloped, dsDNA viruses that are common in mammals, including humans. All polyomaviruses encode the large T-antigen and small t-antigen proteins that share conserved functional domains, comprising binding motifs for the tumor suppressors pRb and p53, and for ...

Last Updated: 14 Apr 2015

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Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.
 

Author(s): Shailender Bhatia, Olga Afanasiev, Paul Nghiem

Journal: Curr Oncol Rep. 2011 Dec;13(6):488-97.

 

Merkel cell carcinoma (MCC) is an aggressive skin malignancy with a high mortality rate and an increasing incidence. The recent discovery of Merkel cell polyomavirus has revolutionized our understanding of MCC pathogenesis. Viral oncoproteins appear to play a critical role in tumor ...

Last Updated: 10 Nov 2011

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Merkel cell carcinoma: a virus-induced human cancer.
 

Author(s): Yuan Chang, Patrick S Moore

Journal: Annu Rev Pathol. 2012 ;7():123-44.

 

Merkel cell polyomavirus (MCV) is the first polyomavirus directly linked to human cancer, and its recent discovery helps to explain many of the enigmatic features of Merkel cell carcinoma (MCC). MCV is clonally integrated into MCC tumor cells, which then require continued MCV oncoprotein ...

Last Updated: 8 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

MLN0128 in Recurrent/Metastatic Merkel Cell Carcinoma
 

Status: Recruiting

Condition Summary: Merkel Cell Carcinoma

 

Last Updated: 29 Dec 2016

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Last Updated: 12 Sep 2016

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Avelumab in Subjects With Merkel Cell Carcinoma (JAVELIN Merkel 200)
 

Status: Recruiting

Condition Summary: Carcinoma, Merkel Cell

 

Last Updated: 21 Dec 2016

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