Moebius Syndrome

Common Name(s)

Moebius Syndrome, Mobius syndrome

Moebius syndrome is a rare neurological condition that primarily affects the muscles that control facial expression and eye movement. Signs and symptoms of the condition may include weakness or paralysis of the facial muscles; feeding, swallowing, and choking problems; excessive drooling; crossed eyes; lack of facial expression; eye sensitivity; high or cleft palate; hearing problems; dental abnormalities; bone abnormalities in the hands and feet; and/or speech difficulties. Affected children often experience delayed development of motor skills (such as crawling and walking), although most eventually acquire these skills. Moebius syndrome is caused by the absence or underdevelopment of the 6th and 7th cranial nerves, which control eye movement and facial expression. Other cranial nerves may also be affected. There is no cure for Moebius syndrome, but proper care and treatment give many individuals a normal life expectancy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Moebius Syndrome" for support, advocacy or research.

Moebius Syndrome Foundation

Our mission is to provide information and support to individuals with Moebius Syndrome and their families, promote greater awareness and understanding of Moebius Syndrome, and advocate for scientific research.

Last Updated: 5 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Moebius Syndrome" for support, advocacy or research.

Moebius Syndrome Foundation

Our mission is to provide information and support to individuals with Moebius Syndrome and their families, promote greater awareness and understanding of Moebius Syndrome, and advocate for scientific research.

http://www.moebiussyndrome.com

Last Updated: 5 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Moebius Syndrome" returned 23 free, full-text research articles on human participants. First 3 results:

Moebius syndrome: clinical features, diagnosis, management and early intervention.
 

Author(s): Odoardo Picciolini, Matteo Porro, Elisa Cattaneo, Silvia Castelletti, Giuseppe Masera, Fabio Mosca, Maria Francesca Bedeschi

Journal:

 

Moebius syndrome (MBS) is rare disease characterized by nonprogressive congenital uni- or bi-lateral facial (i. e. VII cranial nerve) and abducens (i. e. VI cranial nerve) palsy. Although the neurological and ophthalmological findings are quite well-known, data concerning the attendant ...

Last Updated: 4 Jun 2016

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Atraumatic restorative technique: case report on dental management of a patient with Moebius syndrome.
 

Author(s): A Pradhan, M Gryst

Journal: Aust Dent J. 2015 Jun;60(2):255-9.

 

Clinical challenges associated with Moebius syndrome, a rare congenital neuromuscular disorder, include orofacial anomalies like microstomia, limited mouth opening and severe gag reflex.

Last Updated: 28 May 2015

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Diagnostic distinctions and genetic analysis of patients diagnosed with moebius syndrome.
 

Author(s): Sarah MacKinnon, Darren T Oystreck, Caroline Andrews, Wai-Man Chan, David G Hunter, Elizabeth C Engle

Journal: Ophthalmology. 2014 Jul;121(7):1461-8.

 

To improve diagnostic assessment in Moebius syndrome by (1) creating more selective diagnostic subgroups and (2) conducting genetic evaluation in a large patient cohort.

Last Updated: 4 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Moebius Syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
 

Status: Recruiting

Condition Summary: Congenital Fibrosis of Extraocular Muscles; Duane Retraction Syndrome; Duane Radial Ray Syndrome; Mobius Syndrome; Brown Syndrome; Marcus Gunn Syndrome; Strabismus Congenital; Horizontal Gaze Palsy; Horizontal Gaze Palsy With Progressive Scoliosis; Facial Palsy; Facial Paresis, Hereditary, Congenital; Third Nerve Palsy; Fourth Nerve Palsy; Sixth Nerve Palsy; Synkinesis; Ocular Motility Disorders; Levator-Medial Rectus Synkinesis; Athabaskan Brainstem Dysgenesis; Tongue Paralysis; Ninth Nerve Disorder; Fifth Nerve Palsy; Seventh Nerve Palsy; Eleventh Nerve Disorder; Twelfth Nerve Disorder; Vagus Nerve Paralysis; Moebius Sequence

 

Last Updated: 16 Feb 2017

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