Monomelic amyotrophy

Common Name(s)

Monomelic amyotrophy

Monomelic amyotrophy, also known as Hirayama disease, is characterized by insidious onset of weakness and wasting of the muscles of the hand and forearm. It is usually unilateral, but can be bilateral. It occurs most commonly as a sporadic condition, is most common in young men, and follows a relatively benign course after a few years of progression ({9:Nalini et al., 2004}; {8:Misra et al., 2005}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Monomelic amyotrophy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Monomelic amyotrophy" returned 14 free, full-text research articles on human participants. First 3 results:

Monomelic amyotrophy with proximal upper limb involvement: a case report.
 

Author(s): Eman Al-Ghawi, Talal Al-Harbi, Adnan Al-Sarawi, Mohamed Binfalah

Journal:

 

Monomelic amyotrophy is an uncommon, benign, unilateral disorder of the lower motor neurons, affecting predominantly the hand and forearm muscles. Proximal involvement of the arm and shoulder muscles is an unusual presentation that has been rarely reported in the literature.

Last Updated: 17 Mar 2016

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Clinical improvement of monomelic amyotrophy after avoidance of sustained neck flexion.
 

Author(s): Colin Quinn, Sabrina Paganoni, Thomas Cochrane

Journal: J Clin Neuromuscul Dis. 2014 Jun;15(4):191-2.

 

Last Updated: 29 May 2014

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[Effects of a proprioceptive neuromuscular facilitation program on benign monomelic amyotrophy].
 

Author(s): M Orsini, M R G de Freitas, A S B Oliveira, J G Silva, M A A Leite, O J M Nascimento

Journal: Rev Neurol. 2010 Sep;51(5):317-8.

 

Last Updated: 29 Jul 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Monomelic amyotrophy" returned 1 free, full-text review articles on human participants. First 3 results:

Nosology of juvenile muscular atrophy of distal upper extremity: from monomelic amyotrophy to Hirayama disease--Indian perspective.
 

Author(s): Kaukab Maqbool Hassan, Hirdesh Sahni

Journal: Biomed Res Int. 2013 ;2013():478516.

 

Since its original description by Keizo Hirayama in 1959, "juvenile muscular atrophy of the unilateral upper extremity" has been described under many nomenclatures from the east. Hirayama disease (HD), also interchangeably referred to as monomelic amyotrophy, has been more frequently ...

Last Updated: 24 Sep 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Answer ALS: Individualized Initiative for ALS Discovery
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Primary Lateral Sclerosis; Flail Arm ALS; Progressive Muscular Atrophy; Monomelic Amyotrophy; Motor Neuron Disease; Asymptomatic ALS Gene Carriers; Healthy Controls

 

Last Updated: 20 Apr 2017

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