Motor neuron disease

Common Name(s)

Motor neuron disease

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

Logo
The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Motor neuron disease" returned 229 free, full-text research articles on human participants. First 3 results:

Genetic epidemiology of motor neuron disease-associated variants in the Scottish population.
 

Author(s): Holly A Black, Danielle J Leighton, Elaine M Cleary, Elaine Rose, Laura Stephenson, Shuna Colville, David Ross, Jon Warner, Mary Porteous, George H Gorrie, Robert Swingler, David Goldstein, Matthew B Harms, Peter Connick, Suvankar Pal, Timothy J Aitman, Siddharthan Chandran

Journal: Neurobiol. Aging. 2017 Mar;51():178.e11-178.e20.

 

Genetic understanding of motor neuron disease (MND) has evolved greatly in the past 10 years, including the recent identification of association between MND and variants in TBK1 and NEK1. Our aim was to determine the frequency of pathogenic variants in known MND genes and to assess ...

Last Updated: 16 Jan 2017

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HIV-associated motor neuron disease: HERV-K activation and response to antiretroviral therapy.
 

Author(s): Lauren N Bowen, Richa Tyagi, Wenxue Li, Tariq Alfahad, Bryan Smith, Mary Wright, Elyse J Singer, Avindra Nath

Journal: Neurology. 2016 Oct;87(17):1756-1762.

 

To determine whether there is activation of human endogenous retrovirus K (HERV-K) in amyotrophic lateral sclerosis in HIV infection and whether it might respond to treatment with antiretroviral drugs.

Last Updated: 24 Sep 2016

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MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.
 

Author(s): Kelly E Glajch, Laura Ferraiuolo, Kaly A Mueller, Matthew J Stopford, Varsha Prabhkar, Achille Gravanis, Pamela J Shaw, Ghazaleh Sadri-Vakili

Journal:

 

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons. ALS patients experience rapid deterioration in muscle function with an average lifespan of 3-5 years after diagnosis. Currently, the most effective therapeutic only extends lifespan ...

Last Updated: 7 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Motor neuron disease" returned 24 free, full-text review articles on human participants. First 3 results:

TDP-43/FUS in motor neuron disease: Complexity and challenges.
 

Author(s): Erika N Guerrero, Haibo Wang, Joy Mitra, Pavana M Hegde, Sara E Stowell, Nicole F Liachko, Brian C Kraemer, Ralph M Garruto, K S Rao, Muralidhar L Hegde

Journal: Prog. Neurobiol.. ;145-146():78-97.

 

Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per 100,000 people worldwide, encompasses at least five distinct pathological subtypes, including, ALS-SOD1, ALS-C9orf72, ALS-TDP-43, ALS-FUS and Guam-ALS. The etiology of a major subset of ALS involves ...

Last Updated: 3 Oct 2016

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Patterns of Weakness, Classification of Motor Neuron Disease, and Clinical Diagnosis of Sporadic Amyotrophic Lateral Sclerosis.
 

Author(s): Jeffrey M Statland, Richard J Barohn, April L McVey, Jonathan S Katz, Mazen M Dimachkie

Journal: Neurol Clin. 2015 Nov;33(4):735-48.

 

When approaching a patient with suspected motor neuron disease (MND), the pattern of weakness on examination helps distinguish MND from other diseases of peripheral nerves, the neuromuscular junction, or muscle. MND is a clinical diagnosis supported by findings on electrodiagnostic ...

Last Updated: 30 Oct 2015

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Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model.
 

Author(s): Dan-Jing Yang, Liang Zhu, Jie Ren, Rong-Jie Ma, Hongwen Zhu, Jun Xu

Journal: Neurosci Bull. 2015 Aug;31(4):445-51.

 

Autophagy is the main catabolic pathway in cells for the degradation of impaired proteins and organelles. Accumulating evidence supports the hypothesis that dysfunction of autophagy, leading to an imbalance of proteostasis and the accumulation of toxic proteins in neurons, is a central ...

Last Updated: 8 Aug 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

EncoreAnywhere Use in Motor Neurone Disease
 

Status: Recruiting

Condition Summary: Motor Neuron Disease

 

Last Updated: 12 May 2017

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A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps.
 

Status: Recruiting

Condition Summary: Motor Neuron Disease

 

Last Updated: 6 Nov 2017

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Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Motor Neuron Disease

 

Last Updated: 6 Mar 2017

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