Motor neuron disease

Common Name(s)

Motor neuron disease

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Motor neuron disease" for support, advocacy or research.

Logo
The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Motor neuron disease" returned 226 free, full-text research articles on human participants. First 3 results:

MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.
 

Author(s): Kelly E Glajch, Laura Ferraiuolo, Kaly A Mueller, Matthew J Stopford, Varsha Prabhkar, Achille Gravanis, Pamela J Shaw, Ghazaleh Sadri-Vakili

Journal:

 

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons. ALS patients experience rapid deterioration in muscle function with an average lifespan of 3-5 years after diagnosis. Currently, the most effective therapeutic only extends lifespan ...

Last Updated: 7 Oct 2016

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Development of patient decision support tools for motor neuron disease using stakeholder consultation: a study protocol.
 

Author(s): Anne Hogden, David Greenfield, Jashelle Caga, Xiongcai Cai

Journal:

 

Motor neuron disease (MND) is a terminal, progressive, multisystem disorder. Well-timed decisions are key to effective symptom management. To date, there are few published decision support tools, also known as decision aids, to guide patients in making ongoing choices for symptom ...

Last Updated: 7 Apr 2016

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Neuromuscular Ultrasound in the Assessment of Polyneuropathies and Motor Neuron Disease.
 

Author(s): Jack Shen, Michael S Cartwright

Journal: J Clin Neurophysiol. 2016 Apr;33(2):86-93.

 

Neuromuscular ultrasound is an emerging technology for the evaluation of conditions affecting nerve and muscle, with most of the research focusing on focal neuropathies. Despite this focus, researchers have also investigated the ultrasonographic changes that occur in the nerves and ...

Last Updated: 2 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Motor neuron disease" returned 23 free, full-text review articles on human participants. First 3 results:

Patterns of Weakness, Classification of Motor Neuron Disease, and Clinical Diagnosis of Sporadic Amyotrophic Lateral Sclerosis.
 

Author(s): Jeffrey M Statland, Richard J Barohn, April L McVey, Jonathan S Katz, Mazen M Dimachkie

Journal: Neurol Clin. 2015 Nov;33(4):735-48.

 

When approaching a patient with suspected motor neuron disease (MND), the pattern of weakness on examination helps distinguish MND from other diseases of peripheral nerves, the neuromuscular junction, or muscle. MND is a clinical diagnosis supported by findings on electrodiagnostic ...

Last Updated: 30 Oct 2015

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Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model.
 

Author(s): Dan-Jing Yang, Liang Zhu, Jie Ren, Rong-Jie Ma, Hongwen Zhu, Jun Xu

Journal: Neurosci Bull. 2015 Aug;31(4):445-51.

 

Autophagy is the main catabolic pathway in cells for the degradation of impaired proteins and organelles. Accumulating evidence supports the hypothesis that dysfunction of autophagy, leading to an imbalance of proteostasis and the accumulation of toxic proteins in neurons, is a central ...

Last Updated: 8 Aug 2015

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Challenges in the Understanding and Treatment of Amyotrophic Lateral Sclerosis/Motor Neuron Disease.
 

Author(s): Jeffrey Rosenfeld, Michael J Strong

Journal: Neurotherapeutics. 2015 Apr;12(2):317-25.

 

With the acceleration in our understanding of ALS and the related motor neuron disease has come even greater challenges in reconciling all of the proposed pathogenic mechanisms and how this will translate into impactful treatments. Fundamental issues such as diagnostic definition(s) ...

Last Updated: 21 Apr 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

EncoreAnywhere Use in Motor Neurone Disease
 

Status: Recruiting

Condition Summary: Motor Neuron Disease

 

Last Updated: 12 May 2017

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A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps.
 

Status: Recruiting

Condition Summary: Motor Neuron Disease

 

Last Updated: 7 Sep 2017

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Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Motor Neuron Disease

 

Last Updated: 6 Mar 2017

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