Multiple endocrine neoplasia type 1

Common Name(s)

Multiple endocrine neoplasia type 1

Multiple endocrine neoplasia, type 1 (MEN1) is an inherited condition that causes tumors of the endocrine system (the body's network of hormone-producing glands). People affected by MEN1 typically develop tumors of the parathyroid gland, the pituitary gland, and the pancreas, although other glands may be involved as well. These tumors are often "functional" and secrete excess hormones, which can cause a variety of health problems. The most common signs and symptoms of MEN1 are caused by hyperparathyroidism (overactive parathyroid gland) and may include kidney stones; thinning of bones; nausea and vomiting; high blood pressure (hypertension); weakness; and fatigue. MEN1 is caused by changes (mutations) in the MEN1 gene and is inherited in an autosomal dominant manner. Management for MEN1 usually includes regular screening to allow for early diagnosis and treatment of endocrine tumors.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple endocrine neoplasia type 1" for support, advocacy or research.

AMEND

AMEND exists to inform and support anyone affected by multiple endocrine neoplasia disorders and associated endocrine tumors and syndromes, and to encourage and fund research into the conditions through our Annual Research Grant program and Young Investigator Awards. We provide free patient-aimed information resources, including the MEN Passport and AMEND-sponsored children's comics. We also run a variety of free educational events in the UK and USA as well as social and fundraising events. The AMEND website is HONCode certified and the charity runs several social media pages and groups (private and public).

Last Updated: 29 Apr 2014

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American Multiple Endocrine Neoplasia

The Hageman Foundation supports patient advocacy for a rare disease called Multiple Endocrine Neoplasia. This disease is so elusive that we are the only non-profit in this country which supports the thousands of patients who have this genetic disease. The Hageman Foundation’s mission is to provide education, support and research, using accurate, up-to-date, medical information on Multiple Endocrine Neoplasia (MEN), otherwise referred to as MEN1, MEN2A, MEN2B, and the Whipple Procedure, which is detailed on our website: HagemanFoundation.org. The Hageman Foundation’s current initiative is to provide educational seminars and an educational website, AMENsupport.org, which is designed for the patients, their families, and their advisors who would otherwise not have the means or wherewithal to obtain the information and guidance.

Last Updated: 15 Feb 2013

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Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

Last Updated: 31 Jan 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple endocrine neoplasia type 1" for support, advocacy or research.

AMEND

AMEND exists to inform and support anyone affected by multiple endocrine neoplasia disorders and associated endocrine tumors and syndromes, and to encourage and fund research into the conditions through our Annual Research Grant program and Young Investigator Awards. We provide free patient-aimed information resources, including the MEN Passport and AMEND-sponsored children's comics. We also run a variety of free educational events in the UK and USA as well as social and fundraising events. The AMEND website is HONCode certified and the charity runs several social media pages and groups (private and public).

http://www.amend.org.uk

Last Updated: 29 Apr 2014

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American Multiple Endocrine Neoplasia

The Hageman Foundation supports patient advocacy for a rare disease called Multiple Endocrine Neoplasia. This disease is so elusive that we are the only non-profit in this country which supports the thousands of patients who have this genetic disease. The Hageman Foundation’s mission is to provide education, support and research, using accurate, up-to-date, medical information on Multiple Endocrine Neoplasia (MEN), otherwise referred to as MEN1, MEN2A, MEN2B, and the Whipple Procedure, which is detailed on our website: HagemanFoundation.org. The Hageman Foundation’s current initiative is to provide educational seminars and an educational website, AMENsupport.org, which is designed for the patients, their families, and their advisors who would otherwise not have the means or wherewithal to obtain the information and guidance.

http://www.amensupport.org/

Last Updated: 15 Feb 2013

View Details
Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

http://mensociety.ca/

Last Updated: 31 Jan 2013

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General Support Organizations

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General Resources

MEN1 Patient Information Booklet - UK

Detailed booklet on MEN1 written for UK patients to easily understand

Uploaded By: AMEND

Updated 29 Apr 2014

Open Doc
MEN1 Patient Information Booklet - USA

Detailed but easy to read information on MEN1 written for patients in the USA. Produced in 2013

Uploaded By: AMEND

Updated 29 Apr 2014

Open Doc
The Whipple Procedure Patient Information Booklet

Detailed but easy to read information on the surgical procedures known as the Whipple procedure

Uploaded By: AMEND

Updated 29 Apr 2014

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple endocrine neoplasia type 1" returned 162 free, full-text research articles on human participants. First 3 results:

Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing.
 

Author(s): Bo-Young Kim, Mi-Hyun Park, Hae-Mi Woo, Hye-Yeong Jo, Ji Hoon Kim, Hyung Jin Choi, Soo Kyung Koo

Journal:

 

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant hereditary disorder characterized by the presence of endocrine tumors affecting the parathyroid, pancreas, and pituitary. A heterozygous germline inactivating mutation in the MEN1 gene (first hit) may be ...

Last Updated: 3 Oct 2017

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Challenging Differential Diagnosis of Hypergastremia and Hyperglucagonemia with Chronic Renal Failure: Report of a Case with Multiple Endocrine Neoplasia Type 1.
 

Author(s): Takaaki Murakami, Takeshi Usui, Yuji Nakamoto, Akio Nakajima, Yuki Mochida, Sumio Saito, Takahiro Shibayama, Nobuhisa Yamazaki, Tomonobu Hatoko, Tomoko Kato, Shin Yonemitsu, Seiji Muro, Shogo Oki

Journal: Intern. Med.. 2017 ;56(11):1375-1381.

 

A 53-year-old woman developed end-stage renal failure during a 15-year clinical course of primary hyperparathyroidism and was referred to our hospital for evaluation of suspected multiple endocrine neoplasia type 1 (MEN1). Genetic testing revealed a novel deletion mutation at codon ...

Last Updated: 1 Jun 2017

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A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.
 

Author(s): Hiroyuki Matsubayashi, Noboru Kawata, Naomi Kakushima, Masaki Tanaka, Kohei Takizawa, Yoshimi Kiyozumi, Yasue Horiuchi, Keiko Sasaki, Teiichi Sugiura, Katsuhiko Uesaka, Hiroyuki Ono

Journal:

 

In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia due to reflux esophagitis with severe esophageal stricture. ...

Last Updated: 8 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple endocrine neoplasia type 1" returned 29 free, full-text review articles on human participants. First 3 results:

Thoracic and duodenopancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: natural history and function of menin in tumorigenesis.
 

Author(s): C R C Pieterman, E B Conemans, K M A Dreijerink, J M de Laat, H Th M Timmers, M R Vriens, G D Valk

Journal:

 

Mutations of the multiple endocrine neoplasia type 1 (MEN1) gene lead to loss of function of its protein product menin. In keeping with its tumor suppressor function in endocrine tissues, the majority of the MEN1-related neuroendocrine tumors (NETs) show loss of heterozygosity (LOH) ...

Last Updated: 7 May 2014

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Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome.
 

Author(s): Francesco Tonelli, Francesco Giudici, Gabriella Nesi, Giacomo Batignani, Maria Luisa Brandi

Journal: World J. Gastroenterol.. 2013 Dec;19(45):8312-20.

 

To describe our patients affected with ectopic biliary tree gastrinoma and review the literature on this topic.

Last Updated: 23 Dec 2013

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Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4).
 

Author(s): Rajesh V Thakker

Journal: Mol. Cell. Endocrinol.. 2014 Apr;386(1-2):2-15.

 

Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving two or more endocrine glands within a single patient. Four major forms of MEN, which are autosomal dominant disorders, are recognized and referred to as: MEN type 1 (MEN1), due to menin mutations; ...

Last Updated: 3 Mar 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Metabolomics and Genetic Diagnosing Pancreatic Neuroendocrine Tumors in MEN1 Patients
 

Status: Recruiting

Condition Summary: Multiple Endocrine Neoplasia

 

Last Updated: 7 Feb 2017

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Non-functioning Pancreatic Neuroendocrine Tumors in MEN1: Somatostatin Analogs Versus NO Treatment
 

Status: Not yet recruiting

Condition Summary: Pancreatic Neuroendocrine Tumors in MEN1

 

Last Updated: 29 Aug 2017

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Type 1 Multiple Endocrine Neoplasia Cohort Study
 

Status: Recruiting

Condition Summary: Type 1-Multiple Endocrine Neoplasia Syndrome

 

Last Updated: 23 Aug 2017

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