Multiple sclerosis

Common Name(s)

Multiple sclerosis, MS

Multiple sclerosis (MS) is an autoimmune disorder that causes damage to the body’s central nervous system (CNS). In a person with MS, the immune system attacks part of the body, specifically myelin, mistaking it for something foreign (from outside the body). Myelin is a fatty substance that covers and protects the nerves. When myelin is damaged, the brain cannot send signals and communicate with the rest of the body. The symptoms depend on the location of the nerves which have damaged myelin. Symptoms may include numbness or weakness in the limbs, partial or complete loss of vision, pain in the body, electric-shock sensations with certain neck movements, lack of coordination, slurred speech, fatigue, dizziness, and problems with the bowel and bladder.

Many people with MS have periods of new symptoms (relapse) that are then followed by periods of improvement in symptoms (remission). This form of MS, which is the most common form, is called relapsing-remitting course. The exact cause of MS is unknown. Researchers believe genetics and environmental factors, such as smoking, diet, or infections during childhood, may play a role.

In order to diagnose this condition, your doctor will take a detailed medical history and perform a physical examination. Your doctor may also perform various tests, such as blood tests, imaging tests, or collect fluid from your spine (spinal tap) to both rule out other conditions and find evidence of MS. Although there is no cure for MS, there are medications and therapies available to help control the symptoms and slow the progression. Talk with your doctor to decide which treatment plan is best for you. Support groups are also a good resource for support and additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

Last Updated: 5 May 2015

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

Last Updated: 5 May 2015

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National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to mobilize people and resources so everyone affected by MS can live their best lives as we stop MS in its tracks, restore what has been lost, and end MS forever. Our vision is a world free of MS.

Last Updated: 20 Jun 2016

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APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

Last Updated: 12 Aug 2013

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Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

Last Updated: 13 Nov 2012

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple sclerosis" for support, advocacy or research.

Logo
Multiple Sclerosis Association of America

MSAA's mission is to enrich the quality of life for everyone affected by multiple sclerosis. MSAA also serves to promote greater understanding of multiple sclerosis and the diverse needs and challenges of people with MS.

http://www.msassociation.org

Last Updated: 5 May 2015

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Multiple Sclerosis Foundation

The mission of the Multiple Sclerosis Foundation, Inc. is to provide programs and support services to those persons affected by MS that help them maintain their health, safety, self-sufficiency, and personal well-being; and to heighten public awareness of multiple sclerosis in order to elicit financial support for the MSF’s programs and services and promote understanding for those diagnosed with the illness.

http://www.msfocus.org

Last Updated: 5 May 2015

View Details
National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to mobilize people and resources so everyone affected by MS can live their best lives as we stop MS in its tracks, restore what has been lost, and end MS forever. Our vision is a world free of MS.

https://www.nationalmssociety.org

Last Updated: 20 Jun 2016

View Details
APS Foundation of America, Inc.

The APS Foundation of America, Inc. is dedicated to fostering and facilitating joint efforts in the areas of education, public awareness, research and patient services in an effective and ethical manner.

http://www.apsfa.org

Last Updated: 12 Aug 2013

View Details
Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
The Myelin Project

We are an international 501(c)(3) non-profit organization funding medical research and raising awareness for rare brain diseases.

http://www.myelin.org

Last Updated: 13 Nov 2012

View Details
United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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General Resources

Resources for People Living with MS & Their Families

Family Matters, Library & Educational Programs, Find Support, Insurance & Financial Information, Living with Advanced MS, Employment, Resources for Specific Populations, Find Programs & Services in Your Area

Updated 20 Jun 2016

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Resources for People Living with MS & Their Families

Family Matters, Library & Educational Programs, Find Support, Insurance & Financial Information, Living with Advanced MS, Employment, Resources for Specific Populations, Find Programs & Services in Your Area

Updated 20 Jun 2016

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple sclerosis" returned 5447 free, full-text research articles on human participants. First 3 results:

White matter tract-specific quantitative analysis in multiple sclerosis: Comparison of optic radiation reconstruction techniques.
 

Author(s): Chenyu Wang, Alexander Klistorner, Linda Ly, Michael H Barnett

Journal:

 

The posterior visual pathway is commonly affected by multiple sclerosis (MS) pathology that results in measurable clinical and electrophysiological impairment. Due to its highly structured retinotopic mapping, the visual pathway represents an ideal substrate for investigating patho-mechanisms ...

Last Updated: 31 Dec 1969

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Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis.
 

Author(s): Polona Lavtar, Gorazd Rudolf, Aleš Maver, Alenka Hodžić, Nada Starčević Čizmarević, Maja Živković, Saša Šega Jazbec, Zalika Klemenc Ketiš, Miljenko Kapović, Evica Dinčić, Ranko Raičević, Juraj Sepčić, Luca Lovrečić, Aleksandra Stanković, Smiljana Ristić, Borut Peterlin

Journal:

 

Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might ...

Last Updated: 31 Dec 1969

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Quality of life and social support in patients with multiple sclerosis.
 

Author(s): Katarzyna Rosiak, Paweł Zagożdżon

Journal: Psychiatr. Pol.. 2017 Oct;51(5):923-935.

 

Quality of life and needforsocial support in persons diagnosed with multiple sclerosis (MS) are to a large extent determined by the degree of their disability. The aim of the study was to analyze an association between specific forms of MS, subjectively perceived quality of life and social support.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple sclerosis" returned 850 free, full-text review articles on human participants. First 3 results:

Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis.
 

Author(s): Elmira Agah, Arshia Zardoui, Amene Saghazadeh, Mona Ahmadi, Abbas Tafakhori, Nima Rezaei

Journal:

 

Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid (CSF) and peripheral blood concentration of osteopontin (OPN) may have diagnostic and prognostic ...

Last Updated: 31 Dec 1969

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A systematic review of the effectiveness of self-management interventions in people with multiple sclerosis at improving depression, anxiety and quality of life.
 

Author(s): Tara Kidd, Nicola Carey, Freda Mold, Sue Westwood, Maria Miklaucich, Emmanouela Konstantara, Annette Sterr, Debbie Cooke

Journal:

 

Self-management interventions have become increasingly popular in the management of long-term health conditions; however, little is known about their impact on psychological well-being in people with Multiple Sclerosis (MS).

Last Updated: 31 Dec 1969

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Critical analysis on the present methods for brain volume measurements in multiple sclerosis.
 

Author(s): Yara Dadalti Fragoso, Paulo Roberto Willie, Marcus Vinicius Magno Goncalves, Joseph Bruno Bidin Brooks

Journal: Arq Neuropsiquiatr. 2017 Jul;75(7):464-469.

 

The treatment of multiple sclerosis (MS) has quickly evolved from a time when controlling clinical relapses would suffice, to the present day, when complete disease control is expected. Measurement of brain volume is still at an early stage to be indicative of therapeutic decisions in MS.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Swiss Multiple Sclerosis Registry
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 29 Nov 2016

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A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 26 Aug 2017

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