Madelung's disease

Common Name(s)

Madelung's disease, Multiple symmetric lipomatosis, Launois-Bensaude adenolipomatosis, Familial symmetric lipomatosis

Madelung disease is a rare condition characterized by the symmetric growth of fatty tumors (lipomas) around the neck, shoulders, upper arms and/or upper trunk. It most often affects men of Mediterranean ancestry between the ages of 30 and 70 who have a history of alcohol abuse. Non-alcoholics and women can also be affected. The signs and symptoms vary greatly from person to person. Usually, accumulation of fatty tissue increases over time and may lead to a loss of neck mobility and pain. The lipomas can cause physical deformity and peripheral neuropathy. In the majority of cases, the disease is benign; however, lipomas can become cancerous in rare circumstances. The exact cause of Madelung disease is unknown, but it may be associated with changes (mutations) in mitochondrial DNA and/or alcoholism. Treatment may include medications to correct associated metabolic conditions; surgery or liposuction to remove the lipomas; and avoidance of alcohol.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Madelung's disease" for support, advocacy or research.

Fat Disorders Research Society

FDRS is dedicated to improving the quality of life for all people affected by adipose tissue disorders such as lipedema, lipoedema, Dercum's Disease, Madelung's Disease and Familial Multiple Lipomatosis, through research, education, advocacy and collaboration.

Last Updated: 9 Mar 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Madelung's disease" for support, advocacy or research.

Fat Disorders Research Society

FDRS is dedicated to improving the quality of life for all people affected by adipose tissue disorders such as lipedema, lipoedema, Dercum's Disease, Madelung's Disease and Familial Multiple Lipomatosis, through research, education, advocacy and collaboration.

http://www.fatdisorders.org

Last Updated: 9 Mar 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Madelung's disease" returned 16 free, full-text research articles on human participants. First 3 results:

IMAGES IN CLINICAL MEDICINE. Madelung's Disease.
 

Author(s): Giuseppe Nisi, Andrea Sisti

Journal: N. Engl. J. Med.. 2016 Feb;374(6):572.

 

Last Updated: 11 Feb 2016

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Multiple symmetrical lipomatosis (Madelung's disease).
 

Author(s): Ísis Ikumi Shibasaki, Hélder Ikuo Shibasaki, Tiago de Souza Nakamoto, Flávia Scarinci Baccan, Luiz Sergio Raposo

Journal: Braz J Otorhinolaryngol. ;80(1):90-1.

 

Last Updated: 14 Mar 2014

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Madelung's disease associated with polyneuropathy and symptomatic hypokalemia.
 

Author(s): Hoi-Fong Chan, Yu Sun, Cheng-Huai Lin, Rong-Chi Chen

Journal: J. Formos. Med. Assoc.. 2013 May;112(5):283-6.

 

Madelung's disease (multiple symmetric lipomatosis) is a rare disease characterized by abnormal diffuse lipomatosis in proximal upper limbs and neck. Previous reports have shown that this disease is associated with alcoholism, polyneuropathy, mitochondrial disease, and glucose intolerance. ...

Last Updated: 10 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Madelung's disease" returned 1 free, full-text review articles on human participants. First 3 results:

Madelung's disease as a rare cause of obstructive sleep apnea.
 

Author(s): Vitor Alexandre Oliveira Fonseca, Carlos Alves, Helena Marques, Elvira Camacho, António Pinto Saraiva

Journal: J Bras Pneumol. 2009 Oct;35(10):1053-6.

 

Madelung's disease, or multiple symmetric lipomatosis, is a rare disease, characterized by accumulation of unencapsulated fat, generally located symmetrically around the neck and shoulders. Here, we present the case of a patient with diffuse lipomatosis accompanied by obstructive ...

Last Updated: 17 Nov 2009

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Identification of Mutations Responsible for Rare Familial Skin Diseases by Next Generation Sequencing
 

Status: Recruiting

Condition Summary: Familial Lipomatosis; Very Rare Dermatologic Diseases

 

Last Updated: 7 Oct 2016

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Insight Into Subcutaneous Adipose Tissue Disorders
 

Status: Recruiting

Condition Summary: Lipedema; Dercum's Disease; Familial Multiple Lipomatosis; Madelung's Disease

 

Last Updated: 14 Sep 2017

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Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer
 

Status: Not yet recruiting

Condition Summary: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Leukemia in Remission; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Acute Myeloid Leukemia With FLT3/ITD Mutation; Acute Myeloid Leukemia With Gene Mutations; Aplastic Anemia; B-Cell Non-Hodgkin Lymphoma; CD40 Ligand Deficiency; Chronic Granulomatous Disease; Chronic Leukemia in Remission; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Congenital Amegakaryocytic Thrombocytopenia; Congenital Neutropenia; Congenital Pure Red Cell Aplasia; Glanzmann Thrombasthenia; Immunodeficiency Syndrome; Myelodysplastic Syndrome; Myelofibrosis; Myeloproliferative Neoplasm; Paroxysmal Nocturnal Hemoglobinuria; Plasma Cell Myeloma; Polycythemia Vera; Recurrent Non-Hodgkin Lymphoma; Refractory Non-Hodgkin Lymphoma; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndrome; Severe Aplastic Anemia; Shwachman-Diamond Syndrome; Sickle Cell Disease; T-Cell Non-Hodgkin Lymphoma; Thalassemia; Waldenstrom Macroglobulinemia; Wiskott-Aldrich Syndrome

 

Last Updated: 14 Nov 2017

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