Murine typhus

Common Name(s)

Murine typhus

Murine typhus is a type of bacterial infection that comes from fleas that live on rats, opossums, or cats. It is a type of typhus, which is any disease caused by the Rickettsia bacteria. Murine typhus occurs worldwide, but mainly occurs in urban areas such as cities and ports, where there are many rats or other animals that are more likely to be infected with fleas.

Murine typhus is hard to diagnose because many of its symptoms may resemble other infections and diseases. The condition usually begins with flu-like symptoms such as a sudden fever, chills, headache, muscle pains, and vomiting about 1-3 weeks after being infected. About a week later, about half of infected individuals will develop a rash that begins in the middle of the body, appearing first light pink but then turning dull and red and does not fade. This rash can spread to most of the body, but usually not the face, palms and soles. About 45% of affected individuals will also experience confusion, stupor, seizures or imbalance. While most people survive murine typhus with proper treatment, it can be dangerous and lead to death in the elderly, disabled, or others with poor immune function.

To prevent murine typhus, avoid areas that may have rat fleas or lice. If you think you may have been in one of these areas, bathing, boiling your clothes, and using insecticides may help get rid of lice or fleas. If a similar rash or other more serious symptoms appear, talk to a doctor about current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Murine typhus" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Murine typhus" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Murine typhus" returned 73 free, full-text research articles on human participants. First 3 results:

Significance of major international seaports in the distribution of murine typhus in Taiwan.
 

Author(s): Chi-Chien Kuo, Nicola Wardrop, Chung-Te Chang, Hsi-Chieh Wang, Peter M Atkinson

Journal:

 

International seaports are hotspots for disease invasion and pathogens can persist in seaports even after ports are abandoned. Transmitted by fleas infected by Rickettsia typhi, murine typhus, a largely neglected and easily misdiagnosed disease, is known to occur primarily in large ...

Last Updated: 6 Mar 2017

Go To URL
Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus.
 

Author(s): Mohammad Gharaibeh, Monica Hagedorn, Stefanie Lilla, Matthias Hauptmann, Holger Heine, Bernhard Fleischer, Christian Keller

Journal:

 

Scrub typhus is a potentially lethal infection that is caused by the obligate intracellular bacterium Orientia tsutsugamushi The roles of Toll-like receptor 2 (TLR2) and TLR4 in innate recognition of O. tsutsugamushi have not been elucidated. By overexpression of TLR2 or TLR4 in HEK293 ...

Last Updated: 13 Sep 2016

Go To URL
Opossums and Cat Fleas: New Insights in the Ecology of Murine Typhus in Galveston, Texas.
 

Author(s): Lucas S Blanton, Boluwatife M Idowu, Tyler N Tatsch, Joshua M Henderson, Donald H Bouyer, David H Walker

Journal: Am. J. Trop. Med. Hyg.. 2016 Aug;95(2):457-61.

 

Murine typhus is an acute undifferentiated febrile illness caused by Rickettsia typhi The classic reservoir (Rattus spp.) and flea vector (Xenopsylla cheopis) were once culprits of murine typhus in the United States. Vector and rodent control efforts have drastically decreased the ...

Last Updated: 4 Aug 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Murine typhus" returned 3 free, full-text review articles on human participants. First 3 results:

Severe murine typhus with pulmonary system involvement.
 

Author(s): Thomas W van der Vaart, Pieter P A M van Thiel, Nicole P Juffermans, Michèle van Vugt, Suzanne E Geerlings, Martin P Grobusch, Abraham Goorhuis

Journal: Emerging Infect. Dis.. 2014 Aug;20(8):1375-7.

 

We encountered a case of severe murine typhus complicated by acute respiratory distress syndrome. To determine worldwide prevalence of such cases, we reviewed the literature and found that respiratory symptoms occur in ≈30% of murine typhus patients. In disease-endemic areas, murine ...

Last Updated: 26 Jul 2014

Go To URL
Concurrent Infection with murine typhus and scrub typhus in southern Laos--the mixed and the unmixed.
 

Author(s): Koukeo Phommasone, Daniel H Paris, Tippawan Anantatat, Josée Castonguay-Vanier, Sommay Keomany, Phoutthalavanh Souvannasing, Stuart D Blacksell, Mayfong Mayxay, Paul N Newton

Journal:

 

Last Updated: 6 Sep 2013

Go To URL
Murine (endemic) typhus in Brazil: case report and review.
 

Author(s): Luiz J Silva, Priscila M O Papaiordanou

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;46(5):283-5.

 

Murine typhus has been increasingly recognized worldwide and is becoming a relevant differential diagnosis in febrile conditions. In Brazil, murine typhus has never received much attention. We present a recently diagnosed case and a literature review that suggests that the disease ...

Last Updated: 1 Nov 2004

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Scrub Typhus Antibiotic Resistance Trial
 

Status: Not yet recruiting

Condition Summary: Scrub Typhus

 

Last Updated: 8 May 2017

Go to URL
Scrub Typhus Pediatric Immunology Study
 

Status: Recruiting

Condition Summary: Scrub Typhus

 

Last Updated: 31 Aug 2016

Go to URL
Scrub Typhus RDT Study
 

Status: Not yet recruiting

Condition Summary: The Prevalence of Scrub Typhus

 

Last Updated: 29 Aug 2017

Go to URL