Myasthenia gravis

Common Name(s)

Myasthenia gravis

Myasthenia gravis (MG) is an autoimmune disease that impacts an affected individual’s control of the skeletal muscles. The condition is typically seen in women below the age of 40, and in men above the age of 60. However, there are cases where MG has developed in individuals of all ages.

Symptoms of this condition may include muscle weakness, drooping eyelids, double vision, difficulty swallowing or eating, trouble talking, being unable to fully control facial expressions, fatigue, and difficulty breathing. The muscle weakness appears to increase after the individual is active, but then improves after rest.

Acetylcholine is a chemical that is normally present in the nervous system and is important for passing messages from the brain to the skeletal muscles. In individuals with MG, the body produces antibodies (proteins that are used to detect harmful agents in the body) which mistakenly attack certain sites that are responsible for receiving the acetylcholine messages. As a result, the symptoms of MG occur since the nervous system cannot communicate properly with the muscles. This response is an example of an autoimmune disease, where the body mistakenly begins attacking itself.

Removal of the thymus gland (an organ that is part of the immune system), blood plasma exchanges (where harmful antibodies are removed), and the use of certain types of medications are all current forms of treatment for MG. Other ways to manage the symptoms may include avoiding stressful situations and getting plenty of rest.

Although there is no cure for MG at this time, there are many treatment options available. Doctors seek help from various therapists and community services to provide support and care for families. Talk with a doctor or specialist if you or someone in your family has been diagnosed with Myasthenia gravis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

View Details
Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

http://www.myasthenia.org

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myasthenia gravis" returned 1067 free, full-text research articles on human participants. First 3 results:

The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: A single-subject design study.
 

Author(s): Elisabet Westerberg, Carl Johan Molin, Sören Spörndly Nees, Johan Widenfalk, Anna Rostedt Punga

Journal: Medicine (Baltimore). 2018 Aug;97(31):e11510.

 

There is a need for tailored exercise recommendations to patients with Myasthenia gravis (MG). A few pilot studies have recently shown that physical exercise in accordance with general recommendations to healthy adults can be applied safely to patients with mild MG symptoms. How physical ...

Last Updated: 31 Dec 1969

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Modified unilateral video-assisted thoracoscopic extended thymectomy for myasthenia gravis using 5-mm incisions: A case report.
 

Author(s): Ping-Ming Fan, Guo-Ping Chen, Chao-Na Jiang, Peng-Fei Lv, Jing-Tai Li, Zhi-Lin Chen, Li-Ping Zheng, Jie-Zhi Su, Wu-Ping Zheng

Journal: Medicine (Baltimore). 2018 Aug;97(31):e11237.

 

Myasthenia gravis (MG) is the most common cause of acquired neuromuscular junction disorder. Thymectomy has been established as an effective therapy for MG, as it attenuates the natural course of the disease and may result in complete remission.

Last Updated: 31 Dec 1969

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[Results of extended transsternal thymectomy for Myasthenia gravis. Experience with 58 patients].
 

Author(s): Roberto González L, Alejandra Riquelme U, Mario Fuentealba S, Jorge Canales Z, Alberto Fuentes E, René Saldías F, Enrique Seguel S, Aleck Stockins L, Andrés Jadue T, Emilio Alarcón C

Journal: Rev Med Chil. 2018 Apr;146(4):460-469.

 

Thymectomy improves clinical outcomes and decreases the need for medical treatment in patients with myasthenia gravis (MG).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myasthenia gravis" returned 77 free, full-text review articles on human participants. First 3 results:

Gluten and Neuroimmunology. Rare association with Myasthenia Gravis and Literature Review.
 

Author(s): Francisco Oliveira, Vinicius Schoeps, Wilson Sanvito, Berenice Valerio

Journal: Rev Assoc Med Bras (1992). 2018 Apr;64(4):311-314.

 

As the celiac disease (CD), the non-celiac gluten sensitivity (NCGS) has also been associated with several autoimmune manifestations. It is rarely associated with myasthenia gravis (MG). This paper shall introduce the case of a young female patient, initially presenting a peripheral ...

Last Updated: 31 Dec 1969

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Treatment of Ocular Myasthenia Gravis.
 

Author(s): Wayne T Cornblath

Journal: Asia Pac J Ophthalmol (Phila). ;7(4):257-259.

 

Myasthenia gravis is a relatively common neuromuscular disorder, with ocular myasthenia gravis being a subset defined as myasthenia gravis limited to the orbicularis, levator, and extraocular muscles. Patients with ocular myasthenia gravis can have disabling diplopia or functional ...

Last Updated: 31 Dec 1969

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Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: A case report and literature review.
 

Author(s): Jia-Hung Chen, Kang-Yun Lee, Chaur-Jong Hu, Chen-Chih Chung

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9262.

 

Immune checkpoint inhibitors have led to the development of new approaches for cancer treatment with positive outcomes. However, checkpoint blockade is associated with a unique spectrum of immune-related adverse events (irAEs), which may cause irreversible neurological deficits and even death.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Myasthenia Gravis and Psyche
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 1 Feb 2018

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Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 20 Jul 2018

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Effect of Pyridostigmine (Mestinon) on Muscle Strength in Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 17 Apr 2018

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