Myasthenia gravis

Common Name(s)

Myasthenia gravis

Myasthenia gravis (MG) is an autoimmune disease that impacts an affected individual’s control of the skeletal muscles. The condition is typically seen in women below the age of 40, and in men above the age of 60. However, there are cases where MG has developed in individuals of all ages.

Symptoms of this condition may include muscle weakness, drooping eyelids, double vision, difficulty swallowing or eating, trouble talking, being unable to fully control facial expressions, fatigue, and difficulty breathing. The muscle weakness appears to increase after the individual is active, but then improves after rest.

Acetylcholine is a chemical that is normally present in the nervous system and is important for passing messages from the brain to the skeletal muscles. In individuals with MG, the body produces antibodies (proteins that are used to detect harmful agents in the body) which mistakenly attack certain sites that are responsible for receiving the acetylcholine messages. As a result, the symptoms of MG occur since the nervous system cannot communicate properly with the muscles. This response is an example of an autoimmune disease, where the body mistakenly begins attacking itself.

Removal of the thymus gland (an organ that is part of the immune system), blood plasma exchanges (where harmful antibodies are removed), and the use of certain types of medications are all current forms of treatment for MG. Other ways to manage the symptoms may include avoiding stressful situations and getting plenty of rest.

Although there is no cure for MG at this time, there are many treatment options available. Doctors seek help from various therapists and community services to provide support and care for families. Talk with a doctor or specialist if you or someone in your family has been diagnosed with Myasthenia gravis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

View Details
Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

http://www.myasthenia.org

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myasthenia gravis" returned 1037 free, full-text research articles on human participants. First 3 results:

CTLA-4 methylation regulates the pathogenesis of myasthenia gravis and the expression of related cytokines.
 

Author(s): Ti-Kun Fang, Cheng-Jun Yan, Juan Du

Journal: Medicine (Baltimore). 2018 May;97(18):e0620.

 

Myasthenia gravis (MG) is a progressive autoimmune disease that occurs as a result of the failure of neuromuscular transmission and is characterized by muscle weakness. There has been evidence on the correlations between the genetic predisposition of cytotoxic T lymphocyte and the ...

Last Updated: 31 Dec 1969

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Acetylcholine receptor antibody-positive myasthenia gravis associated with small-cell lung cancer: A case report.
 

Author(s): Masahiro Yamasaki, Kunihiko Funaishi, Naomi Saito, Tomomi Yonekawa, Takemori Yamawaki, Daisuke Ihara, Wakako Daido, Sayaka Ishiyama, Naoko Deguchi, Masaya Taniwaki, Noboru Hattori

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0541.

 

Only few cases of myasthenia gravis (MG) associated with small-cell lung cancer (SCLC) have been reported, and cases positive for acetylcholine receptor antibody (AChR-ab) are even rarer. The efficacy of standard MG treatment, such as cholinesterase inhibitor therapy, immunosuppressive ...

Last Updated: 31 Dec 1969

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[Myasthenia gravis and its association with lymphoproliferative disorders: a case series].
 

Author(s): Gabriel Cea, Andrés Gallardo V, María Elena Cabrera C

Journal: Rev Med Chil. 2017 Dec;145(12):1626-1630.

 

Myasthenia gravis (MG) is a rare autoimmune disease of the neuromuscular junction. It is characterized by variable weakness and excessive fatigability of skeletal muscles. In the last few years, numerous reports have been published showing the association between autoimmune diseases, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myasthenia gravis" returned 74 free, full-text review articles on human participants. First 3 results:

Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: A case report and literature review.
 

Author(s): Jia-Hung Chen, Kang-Yun Lee, Chaur-Jong Hu, Chen-Chih Chung

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9262.

 

Immune checkpoint inhibitors have led to the development of new approaches for cancer treatment with positive outcomes. However, checkpoint blockade is associated with a unique spectrum of immune-related adverse events (irAEs), which may cause irreversible neurological deficits and even death.

Last Updated: 31 Dec 1969

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New onset of myasthenia gravis after intravesical Bacillus Calmette-Guerin: A case report and literature review.
 

Author(s): Tsubasa Takizawa, Marenori Kojima, Shigeaki Suzuki, Takashi Osada, Satoshi Kitagawa, Jin Nakahara, Shinichi Takahashi, Norihiro Suzuki

Journal: Medicine (Baltimore). 2017 Nov;96(46):e8757.

 

Recently, drug-related myasthenia gravis (MG) has received attention, because the number of reported cases involving MG associated with immune checkpoint inhibitors, a new immunotherapy, is increasing. We present a case involving the new onset of MG, in which the symptoms started ...

Last Updated: 31 Dec 1969

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Regulatory T cells in multiple sclerosis and myasthenia gravis.
 

Author(s): K M Danikowski, S Jayaraman, B S Prabhakar

Journal:

 

Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically susceptible individuals. On the other hand, myasthenia gravis (MG) primarily involves destruction of the ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Myasthenia Gravis and Psyche
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 1 Feb 2018

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Effect of Pyridostigmine (Mestinon) on Muscle Strength in Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 17 Apr 2018

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Trial of Orencia in Patients With Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 15 Aug 2017

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