Myxoid liposarcoma

Common Name(s)

Myxoid liposarcoma

Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion (review by {4:Dei Tos, 2000}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myxoid liposarcoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myxoid liposarcoma" returned 83 free, full-text research articles on human participants. First 3 results:

[Subcutaneous myxoid liposarcoma].
 

Author(s): Asmâa Naim, Nadia Benchekroune, Zineb Bouchbika, Nezha Taoufiq, Hassan Jouhadi, Souha Sahraoui, Abdelatif Benider

Journal:

 

Although myxoid liposarcomas (MLS) are the most common type of soft-tissue sarcomas in adults, their primary location in the superficial tissues is rare. So sarcomas are classified as superficial and deep-seated. They are distinct based on their location and their frequency as well ...

Last Updated: 23 May 2017

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Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation.
 

Author(s): Marieke A de Graaff, Jamie S E Yu, Hannah C Beird, Davis R Ingram, Theresa Nguyen, Jeffrey Juehui Liu, Svetlana Bolshakov, Károly Szuhai, Pierre Åman, Keila E Torres, Dina Lev, Torsten O Nielsen, Judith V M G Bovée, Alexander J Lazar, Neeta Somaiah

Journal: Lab. Invest.. 2016 Aug;96(8):885-94.

 

Myxoid liposarcoma has the pathognomonic fusion oncogene FUS-DDIT3 encoding a chimeric transcription factor. Metastatic risk is higher with an increased round cell component and has been linked to aberrations involving the IGFR/PI3K/AKT pathway. These molecular insights have yet to ...

Last Updated: 28 Jul 2016

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miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma.
 

Author(s): Y Nezu, K Hagiwara, Y Yamamoto, T Fujiwara, K Matsuo, A Yoshida, A Kawai, T Saito, T Ochiya

Journal: Oncogene. 2016 Dec;35(48):6177-6188.

 

Myxoid/round cell (RC) liposarcomas (MLS) were originally classified into two distinct populations based on histological differences; a myxoid component and a RC component. It is notable that, depending on an increase of the RC component, the prognosis significantly differs. Hence, ...

Last Updated: 9 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myxoid liposarcoma" returned 3 free, full-text review articles on human participants. First 3 results:

[Myxoid primitive liposarcoma of the middle mediastinum].
 

Author(s): Rachid Marouf, Ihssan Alloubi

Journal:

 

Last Updated: 24 Feb 2015

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Lipoblastoma mimicking myxoid liposarcoma: a clinical report and literature review.
 

Author(s): Akihito Nagano, Takatoshi Ohno, Yutaka Nishimoto, Yoshinobu Hirose, Satoru Miyake, Katsuji Shimizu

Journal: Tohoku J. Exp. Med.. 2011 01;223(1):75-8.

 

Lipoblastoma is an uncommon benign lipomatous tumor, occurring typically in children less than 3 years of age. The magnetic resonance image (MRI) is a useful tool for diagnosis of lipoblastoma; its imaging typically shows high-intensity signals on both T1-weighted (T1-W) and T2 weighted ...

Last Updated: 7 Jan 2011

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Pleural myxoid liposarcoma: features of 2 cases and associated literature review.
 

Author(s): Paul Goldsmith, Kostas Papagiannopoulos

Journal:

 

Primary pleural myxoid liposarcoma is a rare entity and no agreed treatment options have been formulated once diagnosis has been made. We report two cases with subsequent management and make recommendations for treatment pathways in these rare cases.

Last Updated: 15 Jan 2008

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcomas
 

Status: Recruiting

Condition Summary: Myxoid Liposarcoma of Soft Tissue

 

Last Updated: 19 Sep 2016

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A Pilot Study of NY-ESO-1ᶜ²⁵⁹T Cells in Subjects With Advanced Myxoid/ Round Cell Liposarcoma
 

Status: Recruiting

Condition Summary: Myxoid Round Cell Liposarcoma; High Grade Myxoid Liposarcoma

 

Last Updated: 5 Sep 2017

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Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma
 

Status: Recruiting

Condition Summary: Conventional Chondrosarcoma; Myxoid Liposarcoma; Mesenchymal Chondrosarcoma; Dedifferentiated Chondrosarcoma

 

Last Updated: 11 Jul 2016

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