Necrotizing enterocolitis

Common Name(s)

Necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

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Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

Last Updated: 26 Sep 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

Logo
Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

http://www.action.org.uk/

Last Updated: 26 Sep 2013

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General Resources

Action Medical Research - Necrotising Enterocolitis Resources Page

Right now researchers are developing a new test to help identify and treat NEC as fast as possible. They hope this test will reduce the chances of the disease becoming life threatening.

Updated 26 Sep 2013

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Key research breakthrough on feeding of premature vulnerable babies

The way premature babies are fed in hospitals could be set to change following the results of a research programme – funded by children’s charity Action Medical Research* – which were published online in the journal Pediatrics, 9 April 2012.

Updated 26 Sep 2013

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Tackling a life-threatening disease that can strike newborn babies

Just the name itself sounds nasty and necrotising enterocolitis (NEC) is certainly that. It’s a serious bowel disease that typically strikes without warning, mainly affecting premature babies who are already very vulnerable.

Updated 26 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Necrotizing enterocolitis" returned 244 free, full-text research articles on human participants. First 3 results:

Postoperative characteristics of infants who developed necrotizing enterocolitis with different postnatal ages.
 

Author(s): Xiaowen Li, Lei Li, Yan Wang, Chun Deng, Chunbao Guo

Journal: Medicine (Baltimore). 2017 Aug;96(32):e7774.

 

Our goal was to investigate the surgical procedures, postoperative complications, and survival with regard to different onset timing of necrotizing enterocolitis (NEC).We performed a retrospective review of medical records with a diagnosis of NEC between 2005 and 2016. The cutoff ...

Last Updated: 10 Aug 2017

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Circulating fibrocytes are involved in inflammation and leukocyte trafficking in neonates with necrotizing enterocolitis.
 

Author(s): Ye Liu, Shang Qingjuan, Zongwei Gao, Chun Deng, Yan Wang, Chunbao Guo

Journal: Medicine (Baltimore). 2017 Jun;96(26):e7400.

 

Fibrocytes, ahematopoietic stem cell source of fibroblasts/myofibroblasts, were previously implicated to infiltrate into the intestinal and enhance inflammation.The aims of the present study were to elucidate the role of fibrocytes in necrotizing enterocolitis (NEC) pathogenesis and ...

Last Updated: 28 Jun 2017

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RNA-Seq for Gene Expression Profiling of Human Necrotizing Enterocolitis: a Pilot Study.
 

Author(s): Kyuwhan Jung, Insong Koh, Jeong Hyun Kim, Hyun Sub Cheong, Taejin Park, So Hyun Nam, Soo Min Jung, Cherry Ann Sio, Su Yeong Kim, Euiseok Jung, Byoungkook Lee, Hye Rim Kim, Eun Shin, Sung Eun Jung, Chang Won Choi, Beyong Il Kim, Eunyoung Jung, Hyoung Doo Shin

Journal: J. Korean Med. Sci.. 2017 May;32(5):817-824.

 

Necrotizing enterocolitis (NEC) characterized by inflammatory intestinal necrosis is a major cause of mortality and morbidity in newborns. Deep RNA sequencing (RNA-Seq) has recently emerged as a powerful technology enabling better quantification of gene expression than microarrays ...

Last Updated: 5 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Necrotizing enterocolitis" returned 58 free, full-text review articles on human participants. First 3 results:

Preventing necrotizing enterocolitis by food additives in neonates: A network meta-analysis revealing the efficacy and safety.
 

Author(s): Wentao Yu, Wu Sui, Linsong Mu, Wenying Yi, Haijuan Li, Liqin Wei, Weihong Yin

Journal: Medicine (Baltimore). 2017 May;96(21):e6652.

 

Necrotizing enterocolitis (NEC) is a serious multifactorial gastrointestinal disease which is often discovered in premature infants. Various additives have been used to prevent NEC; yet, their relative efficacy and safety remain disputed. This study aims to compare the efficacy and ...

Last Updated: 24 May 2017

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Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis.
 

Author(s): Mohan Pammi, Julia Cope, Phillip I Tarr, Barbara B Warner, Ardythe L Morrow, Volker Mai, Katherine E Gregory, J Simon Kroll, Valerie McMurtry, Michael J Ferris, Lars Engstrand, Helene Engstrand Lilja, Emily B Hollister, James Versalovic, Josef Neu

Journal:

 

Necrotizing enterocolitis (NEC) is a catastrophic disease of preterm infants, and microbial dysbiosis has been implicated in its pathogenesis. Studies evaluating the microbiome in NEC and preterm infants lack power and have reported inconsistent results.

Last Updated: 9 Mar 2017

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Necrotizing enterocolitis: new insights into pathogenesis and mechanisms.
 

Author(s): Diego F Niño, Chhinder P Sodhi, David J Hackam

Journal: Nat Rev Gastroenterol Hepatol. 2016 Oct;13(10):590-600.

 

Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal tract of preterm infants. At present, NEC is thought to develop in the premature host in the setting of bacterial colonization, often after administration of non-breast milk feeds, and ...

Last Updated: 26 Sep 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clostridium and Neonatal Necrotizing Enterocolitis Pathophysiology : Clinical and Molecular Approaches
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 16 Sep 2015

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Early Predictors of Necrotizing Enterocolitis in Neonates
 

Status: Not yet recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 6 Jul 2017

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Ultrasound, Doppler ,and Calprotectin in Necrotizing Enterocolitis Diagnosis
 

Status: Not yet recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 18 Aug 2017

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