Necrotizing enterocolitis

Common Name(s)

Necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

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Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

Last Updated: 26 Sep 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Necrotizing enterocolitis" for support, advocacy or research.

Logo
Action Medical Research

For over 60 years we’ve been saving and changing lives through medical research and have spent over £100m, funding some amazing breakthroughs. Today in the UK, there are hundreds of thousands of sick and disabled children who need help. We find and fund the best research to help these children.

http://www.action.org.uk/

Last Updated: 26 Sep 2013

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General Resources

Action Medical Research - Necrotising Enterocolitis Resources Page

Right now researchers are developing a new test to help identify and treat NEC as fast as possible. They hope this test will reduce the chances of the disease becoming life threatening.

Updated 26 Sep 2013

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Key research breakthrough on feeding of premature vulnerable babies

The way premature babies are fed in hospitals could be set to change following the results of a research programme – funded by children’s charity Action Medical Research* – which were published online in the journal Pediatrics, 9 April 2012.

Updated 26 Sep 2013

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Tackling a life-threatening disease that can strike newborn babies

Just the name itself sounds nasty and necrotising enterocolitis (NEC) is certainly that. It’s a serious bowel disease that typically strikes without warning, mainly affecting premature babies who are already very vulnerable.

Updated 26 Sep 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Necrotizing enterocolitis" returned 282 free, full-text research articles on human participants. First 3 results:

Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study.
 

Author(s): Margareta Ahle, Peder Drott, Anders Elfvin, Roland E Andersson

Journal:

 

To analyze associations of maternal, fetal, gestational, and perinatal factors with necrotizing enterocolitis in a matched case-control study based on routinely collected, nationwide register data.

Last Updated: 31 Dec 1969

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[Effect of Bifidobacterium on the expression of β-defensin-2 in intestinal tissue of neonatal rats with necrotizing enterocolitis].
 

Author(s): Wei-Cheng Lu, Xu Zheng, Jin-Fu Liu, Wen-Chuan Wu, Xing-Yue Chen, Hai-Bo Wei, Chun-Lei Li, Ming-Jing Lin

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2018 Mar;20(3):224-229.

 

To study the effect of Bifidobacterium on the expression of β-defensin-2 (BD-2) in intestinal tissue of neonatal rats with necrotizing enterocolitis (NEC).

Last Updated: 31 Dec 1969

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[Relationship between vitamin D deficiency and necrotizing enterocolitis in preterm infants].
 

Author(s): Ling-Rong Yang, Hua Li, Tong Zhang, Ru-Cui Zhao

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2018 Mar;20(3):178-183.

 

To evaluate the relationship of vitamin D level with the development of necrotizing enterocolitis (NEC) in preterm infants.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Necrotizing enterocolitis" returned 69 free, full-text review articles on human participants. First 3 results:

[Research advances in necrotizing enterocolitis in neonates].
 

Author(s): Xin Gan, Juan Li

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2018 Feb;20(2):164-168.

 

Necrotizing enterocolitis (NEC) is a catastrophic disease caused by a variety of factors in neonates, especially preterm infants. Severe NEC has a high fatality rate, and most survivors may face short- and long-term adverse prognosis. Risk factors for NEC include preterm birth, non-breastfeeding, ...

Last Updated: 31 Dec 1969

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Surgical management of Necrotizing Enterocolitis in an Incredibly Low Birth Weight infant and review of the Literature.
 

Author(s): A Zangari, C Noviello, S Nobile, G Cobellis, C Gulia, R Piergentili, S Gigli, V Carnielli

Journal: Clin Ter. ;168(5):e297-e299.

 

Survival of preterm infants have dramatically improved over the last decades. Nonetheless, infants born preterm remain vulnerable to many complications, including necrotizing enterocolitis (NEC). The severity of the disease and the mortality rate are directly correlated with decreasing ...

Last Updated: 31 Dec 1969

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Preventing necrotizing enterocolitis by food additives in neonates: A network meta-analysis revealing the efficacy and safety.
 

Author(s): Wentao Yu, Wu Sui, Linsong Mu, Wenying Yi, Haijuan Li, Liqin Wei, Weihong Yin

Journal: Medicine (Baltimore). 2017 May;96(21):e6652.

 

Necrotizing enterocolitis (NEC) is a serious multifactorial gastrointestinal disease which is often discovered in premature infants. Various additives have been used to prevent NEC; yet, their relative efficacy and safety remain disputed. This study aims to compare the efficacy and ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clostridium and Neonatal Necrotizing Enterocolitis Pathophysiology : Clinical and Molecular Approaches
 

Status: Recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 28 May 2018

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Early Predictors of Necrotizing Enterocolitis in Neonates
 

Status: Not yet recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 6 Jul 2017

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Ultrasound, Doppler ,and Calprotectin in Necrotizing Enterocolitis Diagnosis
 

Status: Not yet recruiting

Condition Summary: Necrotizing Enterocolitis

 

Last Updated: 19 Jan 2018

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