Wilms' tumor

Common Name(s)

Wilms' tumor, Nephroblastoma

A Wilms’ tumor, also known as a nephroblastoma, is a rare, cancerous, kidney tumor that affects children. The tumor can be found in one or both kidneys and tends to be found in children between the ages of 3 and 4. The risk for a Wilms’ tumor decreases after the age of 5. Although some children who have a Wilms’ tumor appear healthy, some symptoms may include a lump in the abdomen (abdominal mass), pain or swelling, blood in the urine, nausea, constipation, loss of appetite, and fever.

All tumors are the result of an overgrowth of tissue that is caused by errors in the DNA of a cell. A Wilms’ tumor is the result of this happening in the kidney. There are multiple risk factors for a child having a Wilms’ tumor, including being African American, having a family history of Wilms’ tumors, being born with an abnormality in the colored portion of the eye (aniridia), having one part of the body that is larger than the other (hemihypertrophy), having undescended testicles (cryptorchidism), or having the urinary opening on the underside of the penis (hypospadias). Wilms’ tumors are also seen as part of a few different genetic conditions, including WAGR syndrome, Denys-Drash Syndrome, and Beckwith-Wiedemann syndrome.

A diagnosis is usually made using a physical exam, blood and urine tests, and imaging tests (CT or MRI). Once a diagnosis is made, the options for treatment include surgery to remove the tumor, chemotherapy, or radiation. Recent improvements for detection and treatment of a Wilms’ tumor has improved the outlook for many children. If your child has been diagnosed with a Wilms’ tumor, talk with their doctor about all treatment options. Support groups can provide additional information and connect you with other affected families.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

Last Updated: 24 Jul 2015

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International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

Last Updated: 12 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

http://www.trisomy18.org

Last Updated: 24 Jul 2015

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International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

http://www.wagr.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wilms' tumor" returned 305 free, full-text research articles on human participants. First 3 results:

Wilms' tumor 1 (WT1) as a prognosis factor in gynecological cancers: A meta-analysis.
 

Author(s): Jingjing Lu, Yang Gu, Qing Li, Huanxin Zhong, Xiaoxue Wang, Zhenxia Zheng, Wenfeng Hu, Lanling Wen

Journal: Medicine (Baltimore). 2018 Jul;97(28):e11485.

 

The oncogenic role of Wilms' tumor 1 (WT1) which is regarded as a promising target antigen for cancer immunotherapy has been demonstrated in many types of cancer, but the relationship between expression of WT1 and the prognosis value in gynecological cancer reminds unclear.We performed ...

Last Updated: 31 Dec 1969

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Outcomes following autologous hematopoietic stem cell transplant for patients with relapsed Wilms' tumor: a CIBMTR retrospective analysis.
 

Author(s): M H Malogolowkin, M T Hemmer, J Le-Rademacher, G A Hale, P A Mehta, A R Smith, C Kitko, A Abraham, H Abdel-Azim, C Dandoy, M Angel Diaz, R P Gale, G Guilcher, R Hayashi, S Jodele, K A Kasow, M L MacMillian, M Thakar, B M Wirk, A Woolfrey, E L Thiel

Journal: Bone Marrow Transplant.. 2017 Nov;52(11):1549-1555.

 

Despite the marked improvement in the overall survival (OS) for patients diagnosed with Wilms' tumor (WT), the outcomes for those who experience relapse have remained disappointing. We describe the outcomes of 253 patients with relapsed WT who received high-dose chemotherapy (HDT) ...

Last Updated: 31 Dec 1969

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MicroRNA-613 attenuates the proliferation, migration and invasion of Wilms' tumor via targeting FRS2.
 

Author(s): H-F Wang, Y-Y Zhang, H-W Zhuang, M Xu

Journal: Eur Rev Med Pharmacol Sci. 2017 Aug;21(15):3360-3369.

 

Wilms' tumor is the most common malignant tumor in children worldwide. Considering the poor therapeutic effect on Wilms' tumor, we determined the effects of microRNA-613 on cell proliferation and metastasis in vitro, providing therapeutic targets for the treatment of Wilms' tumor.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wilms' tumor" returned 21 free, full-text review articles on human participants. First 3 results:

Significance of Wilms' tumor 1 antigen as a cancer vaccine for pancreatic cancer.
 

Author(s): Shigeo Koido, Masato Okamoto, Masanori Kobayashi, Shigetaka Shimodaira, Haruo Sugiyama

Journal: Discov Med. 2017 08;24(130):41-49.

 

Pancreatic ductal adenocarcinoma (PDA) is characterized by a very poor prognosis, despite novel chemotherapeutic treatments. Moreover, the majority of PDA patients with complete surgical resection show recurrence within 5 years of resection. Therefore, new targeted cancer vaccines ...

Last Updated: 31 Dec 1969

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Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review.
 

Author(s): Changkai Deng, Rong Dai, Xuliang Li, Feng Liu

Journal: Cancer Sci.. 2016 May;107(5):690-9.

 

Over the last few decades, numerous biomarkers in Wilms' tumor have been confirmed and shown variations in prevalence. Most of these studies were based on small sample sizes. We carried out a meta-analysis of the research published from 1992 to 2015 to obtain more precise and comprehensive ...

Last Updated: 31 Dec 1969

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Adult Wilms' tumor: A case report with review of literature.
 

Author(s): Amit V Varma, Kamal Malukani, Preeti Rihal, Shirish S Nandedkar

Journal: J Cancer Res Ther. ;11(4):934-6.

 

Wilms' tumor presents a diagnostic problem due to its rare occurrence in adults. Most of the cases of adult Wilms' tumor are diagnosed unexpectedly following nephrectomy for renal cell carcinoma. We are reporting herein a rare case of Adult Wilms' tumor of kidney with triphasic histology ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Collaborative Wilms Tumour Africa Project
 

Status: Recruiting

Condition Summary: Wilms Tumour

 

Last Updated: 14 Nov 2016

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Last Updated: 13 Jul 2018

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Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors
 

Status: Recruiting

Condition Summary: Ewing Sarcoma; Rhabdomyosarcoma; Wilms Tumor; Osteosarcoma; Non-Rhabdomyosarcoma Soft Tissue Sarcoma, Nos; Renal Tumor; Rhabdoid Tumor; Clear Cell Renal Cell Carcinoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Sarcoma

 

Last Updated: 31 Jan 2018

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