Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3462 free, full-text research articles on human participants. First 3 results:

The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells.
 

Author(s): How-Wing Leung, Gabriel Foo, Gokulakrishna Banumurthy, Xiaoran Chai, Sujoy Ghosh, Tora Mitra-Ganguli, Antonius M J VanDongen

Journal:

 

Bacopa monnieri is a plant used as a nootropic in Ayurveda, a 5000-year-old system of traditional Indian medicine. Although both animal and clinical studies supported its role as a memory enhancer, the molecular and cellular mechanism underlying Bacopa's nootropic action are not understood. ...

Last Updated: 23 Aug 2017

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Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment.
 

Author(s): Sabrina Giacoppo, Renato Iori, Patrick Rollin, Placido Bramanti, Emanuela Mazzon

Journal:

 

Several lines of evidence suggest the consume of natural products for cancer prevention or treatment. In particular, isothiocyanates (ITCs) exerting anti-cancer properties, have received great interest as potential chemotherapeutic agents. This study was designed to assess the anti-proliferative ...

Last Updated: 14 Jul 2017

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The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis.
 

Author(s): Madhu Kollareddy, Alice Sherrard, Ji Hyun Park, Marianna Szemes, Kelli Gallacher, Zsombor Melegh, Sebastian Oltean, Martin Michaelis, Jindrich Cinatl, Abderrahmane Kaidi, Karim Malik

Journal: Cancer Lett.. 2017 Sep;403():74-85.

 

Neuroblastoma is a biologically and clinically heterogeneous pediatric malignancy that includes a high-risk subset for which new therapeutic agents are urgently required. As well as MYCN amplification, activating point mutations of ALK and NRAS are associated with high-risk and relapsing ...

Last Updated: 12 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 114 free, full-text review articles on human participants. First 3 results:

Dual tumor - Clear cell sarcoma of kidney with differentiating neuroblastoma: A rare case with review of literature.
 

Author(s): Preeti Rajeev Doshi, Manjiri N Karandikar, Ravi C Swami, Harvinder A Singh, Ravindra C Nimbargi

Journal: Indian J Pathol Microbiol. ;60(1):111-114.

 

Occurrence of two distinct synchronous primary tumors is a rare event in children as well as in adults. Here, we report an extremely rare case of an infant found to have two synchronous Tumours namely clear cell sarcoma of kidney(CCSK) and differentiating neuroblastoma of preaortic ...

Last Updated: 14 Feb 2017

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Neuroblastoma treatment in the post-genomic era.
 

Author(s): Maria Rosaria Esposito, Sanja Aveic, Anke Seydel, Gian Paolo Tonini

Journal:

 

Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratification of neuroblastoma patients within risk groups (low, intermediate, high ...

Last Updated: 9 Feb 2017

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Overview and recent advances in the treatment of neuroblastoma.
 

Author(s): Sarah B Whittle, Valeria Smith, Erin Doherty, Sibo Zhao, Scott McCarty, Peter E Zage

Journal: Expert Rev Anticancer Ther. 2017 Apr;17(4):369-386.

 

Children with neuroblastoma have widely divergent outcomes, ranging from cure in >90% of patients with low risk disease to <50% for those with high risk disease. Recent research has shed light on the biology of neuroblastoma, allowing for more accurate risk stratification and treatment ...

Last Updated: 1 Feb 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Neuroblastoma Precision Trial
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 2 Nov 2017

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Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells
 

Status: Not yet recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 2 Nov 2017

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