Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3545 free, full-text research articles on human participants. First 3 results:

A highly malignant case of neuroblastoma with substantial increase of single-nucleotide variants and normal mismatch repair system: A case report.
 

Author(s): Lin-Qing Yuan, Jin-Hu Wang, Kun Zhu, Min Yang, Wei-Zhong Gu, Can Lai, Hao-Min Li, Qiang Shu, Xi Chen

Journal: Medicine (Baltimore). 2017 Dec;96(50):e8845.

 

Neuroblastoma is a common abdominal malignancy in children. The chemoresistant and relapsed cases have poor prognosis. The genetic background and the mechanism of resistance remain unelucidated. Next-generation sequence (NGS) is becoming a popular tool to unravel the genetic background ...

Last Updated: 31 Dec 1969

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The standardized Withania somnifera Dunal root extract alters basal and morphine-induced opioid receptor gene expression changes in neuroblastoma cells.
 

Author(s): Francesca Felicia Caputi, Elio Acquas, Sanjay Kasture, Stefania Ruiu, Sanzio Candeletti, Patrizia Romualdi

Journal:

 

Behavioral studies demonstrated that the administration of Withania somnifera Dunal roots extract (WSE), prolongs morphine-elicited analgesia and reduces the development of tolerance to the morphine's analgesic effect; however, little is known about the underpinning molecular mechanism(s). ...

Last Updated: 31 Dec 1969

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Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult.
 

Author(s): Zhangyang Qi, Meihao Wu, Yun Fu, Tengfei Huang, Tingting Wang, Yanjie Sun, Zhibo Feng, Changzheng Li

Journal: Cell. Physiol. Biochem.. 2017 ;44(2):618-633.

 

The generation of reactive oxygen species (ROS) caused by amyloid-β (Aβ) is considered to be one of mechanisms underlying the development of Alzheimer's disease. Curcumin can attenuate Aβ-induced neurotoxicity through ROS scavenging, but the protective effect of intracellular curcumin ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 117 free, full-text review articles on human participants. First 3 results:

Dual tumor - Clear cell sarcoma of kidney with differentiating neuroblastoma: A rare case with review of literature.
 

Author(s): Preeti Rajeev Doshi, Manjiri N Karandikar, Ravi C Swami, Harvinder A Singh, Ravindra C Nimbargi

Journal: Indian J Pathol Microbiol. ;60(1):111-114.

 

Occurrence of two distinct synchronous primary tumors is a rare event in children as well as in adults. Here, we report an extremely rare case of an infant found to have two synchronous Tumours namely clear cell sarcoma of kidney(CCSK) and differentiating neuroblastoma of preaortic ...

Last Updated: 31 Dec 1969

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Neuroblastoma treatment in the post-genomic era.
 

Author(s): Maria Rosaria Esposito, Sanja Aveic, Anke Seydel, Gian Paolo Tonini

Journal:

 

Neuroblastoma is an embryonic malignancy of early childhood originating from neural crest cells and showing heterogeneous biological, morphological, genetic and clinical characteristics. The correct stratification of neuroblastoma patients within risk groups (low, intermediate, high ...

Last Updated: 31 Dec 1969

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Overview and recent advances in the treatment of neuroblastoma.
 

Author(s): Sarah B Whittle, Valeria Smith, Erin Doherty, Sibo Zhao, Scott McCarty, Peter E Zage

Journal: Expert Rev Anticancer Ther. 2017 Apr;17(4):369-386.

 

Children with neuroblastoma have widely divergent outcomes, ranging from cure in >90% of patients with low risk disease to <50% for those with high risk disease. Recent research has shed light on the biology of neuroblastoma, allowing for more accurate risk stratification and treatment ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Neuroblastoma Precision Trial
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 17 Jan 2018

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Naxitamab for Neuroblastoma With Osteomedullary Disease
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 8 Jan 2018

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Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells
 

Status: Not yet recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 17 Jan 2018

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