Neutropenia idiopathic

Common Name(s)

Neutropenia idiopathic

Idiopathic neutropenia is an acquired form of severe chronic neutropenia whose cause is unknown.  Neutropenia is a blood condition that causes a reduced number or complete absence of neutrophils, a type of white blood cell that is responsible for much of the body's protection against infection. Symptoms include fever, moth sores, and other types of infections. Neutropenia idiopathic may occur in children and adults. Frequency and severity of infections appear to be directly related to neutrophil count; while clinical problems in individual patients may vary, in general, those patients with more severe neutropenia have more frequent infections. Most patients respond well to granulocyte-colony stimulating factor (G-CSF).  Long-term treatment is usually required.   
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neutropenia idiopathic" for support, advocacy or research.

National Neutropenia Network Inc.

To promote awareness, education, and research, and to provide a support system for patients with severe chronic neutropenia and their families through a national resource network.

Last Updated: 29 Apr 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neutropenia idiopathic" for support, advocacy or research.

National Neutropenia Network Inc.

To promote awareness, education, and research, and to provide a support system for patients with severe chronic neutropenia and their families through a national resource network.

http://www.neutropenianet.org/

Last Updated: 29 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neutropenia idiopathic" returned 16 free, full-text research articles on human participants. First 3 results:

Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination.
 

Author(s): Eva Jolanda Münzel, Jennie Z Wimperis, Anna Williams

Journal:

 

We report the challenges of treating relapsing-remitting multiple sclerosis (MS) in a 31-year-old woman with long-standing chronic idiopathic neutropenia. The treatment with the disease-modifying therapy interferon-β was significantly complicated by a further fall in her generally ...

Last Updated: 18 Feb 2013

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Clonal patterns of X-chromosome inactivation in peripheral blood cells of female patients with chronic idiopathic neutropenia.
 

Author(s): Semeli Mastrodemou, Vasilios Vazgiourakis, Maria Velegraki, Konstantia Pavlaki, George N Goulielmos, Helen A Papadaki

Journal: Haematologica. 2012 Dec;97(12):1931-3.

 

Last Updated: 3 Dec 2012

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Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia.
 

Author(s): Konstantia I Pavlaki, Maria-Christina Kastrinaki, Michail Klontzas, Maria Velegraki, Irene Mavroudi, Helen A Papadaki

Journal: Haematologica. 2012 May;97(5):743-50.

 

Chronic idiopathic neutropenia is characterized by immune-mediated suppression of neutrophil production. Because patients with immune-mediated bone marrow failure syndromes display age-inappropriate telomere shortening in leukocytes, we investigated telomere lengths in peripheral ...

Last Updated: 4 May 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neutropenia idiopathic" returned 1 free, full-text review articles on human participants. First 3 results:

Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia.
 

Author(s): Irene Mavroudi, Helen A Papadaki

Journal: Clin. Dev. Immunol.. 2012 ;2012():123789.

 

Increasing interest on the field of autoimmune diseases has unveiled a plethora of genetic factors that predispose to these diseases. However, in immune-mediated bone marrow failure syndromes, such as acquired aplastic anemia and chronic idiopathic neutropenia, in which the pathophysiology ...

Last Updated: 7 Sep 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO
 

Status: Recruiting

Condition Summary: Febrile Neutropenia; Hematological Malignancy

 

Last Updated: 8 Dec 2015

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