Neutropenia

Common Name(s)

Neutropenia

Neutropenia is a disorder in which individuals have an abnormally low count of neutrophils, a type of white blood cell that helps fight off infections. The low count can be caused by cancer, viral infections, autoimmune disorders or drugs that damage the function of bone marrow or neutrophil cells. The lower the neutrophil count, the more vulnerable an individual is to infection or sickness. Common symptoms of neutropenia include fevers and frequent infections, which can result in mouth ulcers, diarrhea, a burning sensation when urinating, unusual redness, pain, or a sore throat.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neutropenia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neutropenia" returned 947 free, full-text research articles on human participants. First 3 results:

Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency.
 

Author(s): Julien Cottineau, Molly C Kottemann, Francis P Lach, Young-Hoon Kang, Frédéric Vély, Elissa K Deenick, Tomi Lazarov, Laure Gineau, Yi Wang, Andrea Farina, Marie Chansel, Lazaro Lorenzo, Christelle Piperoglou, Cindy S Ma, Patrick Nitschke, Aziz Belkadi, Yuval Itan, Bertrand Boisson, Fabienne Jabot-Hanin, Capucine Picard, Jacinta Bustamante, Céline Eidenschenk, Soraya Boucherit, Nathalie Aladjidi, Didier Lacombe, Pascal Barat, Waseem Qasim, Jane A Hurst, Andrew J Pollard, Holm H Uhlig, Claire Fieschi, Jean Michon, Vladimir P Bermudez, Laurent Abel, Jean-Pierre de Villartay, Frédéric Geissmann, Stuart G Tangye, Jerard Hurwitz, Eric Vivier, Jean-Laurent Casanova, Agata Smogorzewska, Emmanuelle Jouanguy

Journal: J. Clin. Invest.. 2017 May;127(5):1991-2006.

 

Inborn errors of DNA repair or replication underlie a variety of clinical phenotypes. We studied 5 patients from 4 kindreds, all of whom displayed intrauterine growth retardation, chronic neutropenia, and NK cell deficiency. Four of the 5 patients also had postnatal growth retardation. ...

Last Updated: 17 Apr 2017

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Impact of Guidance on the Prescription Patterns of G-CSFs for the Prevention of Febrile Neutropenia Following Anticancer Chemotherapy: A Population-Based Utilization Study in the Lazio Region.
 

Author(s): Francesco Trotta, Flavia Mayer, Alessandra Mecozzi, Laura Amato, Antonio Addis

Journal: BioDrugs. 2017 Apr;31(2):117-124.

 

Current guidelines recommend prophylaxis with granulocyte colony-stimulating factors (G-CSFs) for patients with cancer who are at greater risk of febrile neutropenia (FN) while receiving chemotherapy. G-CSF biosimilars are available and represent a savings opportunity; however, their ...

Last Updated: 29 Mar 2017

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Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?
 

Author(s): Rui-Rui Peng, Juan Wu, Wei Zhao, Tengfei Qi, Mei Shi, Zhifang Guan, Haikong Lu, Fuquan Long, Zixiao Gao, Sufang Zhang, Pingyu Zhou

Journal:

 

Prompt therapy with high-dose intravenous benzylpenicillin for a prolonged period is critical for neurosyphilis patients to avoid irreversible sequelae. However, life-threatening neutropenia has been reported as a complication of prolonged therapy with high doses of benzylpenicillin ...

Last Updated: 13 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neutropenia" returned 85 free, full-text review articles on human participants. First 3 results:

Neutropenia as an Adverse Event following Vaccination: Results from Randomized Clinical Trials in Healthy Adults and Systematic Review.
 

Author(s): Vincent Muturi-Kioi, David Lewis, Odile Launay, Geert Leroux-Roels, Alessandra Anemona, Pierre Loulergue, Caroline L Bodinham, Annelies Aerssens, Nicola Groth, Allan Saul, Audino Podda

Journal:

 

In the context of early vaccine trials aimed at evaluating the safety profile of novel vaccines, abnormal haematological values, such as neutropenia, are often reported. It is therefore important to evaluate how these trials should be planned not to miss potentially important safety ...

Last Updated: 5 Aug 2016

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Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction.
 

Author(s): Lise J Estcourt, Simon J Stanworth, Sally Hopewell, Carolyn Doree, Marialena Trivella, Edwin Massey

Journal:

 

Despite modern antimicrobials and supportive therapy bacterial and fungal infections are still major complications in people with prolonged disease-related or treatment-related neutropenia. Transfusions of granulocytes have a long history of usage in clinical practice to support and ...

Last Updated: 2 May 2016

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Meta-Analysis and Cost Comparison of Empirical versus Pre-Emptive Antifungal Strategies in Hematologic Malignancy Patients with High-Risk Febrile Neutropenia.
 

Author(s): Monica Fung, Jane Kim, Francisco M Marty, Michaël Schwarzinger, Sophia Koo

Journal:

 

Invasive fungal disease (IFD) causes significant morbidity and mortality in hematologic malignancy patients with high-risk febrile neutropenia (FN). These patients therefore often receive empirical antifungal therapy. Diagnostic test-guided pre-emptive antifungal therapy has been ...

Last Updated: 11 Nov 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Saftey and Efficacy of Pegfilgrastim in Preventing Chrmotherapy-induced Neutropenia
 

Status: Recruiting

Condition Summary: Neutropenia

 

Last Updated: 9 Nov 2015

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Management of Severe Chemotherapy-induced Neutropenia in Advanced Breast Cancer
 

Status: Not yet recruiting

Condition Summary: Febrile Neutropenia

 

Last Updated: 8 Aug 2017

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Last Updated: 24 Feb 2017

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