Non-Hodgkin lymphoma

Common Name(s)

Non-Hodgkin lymphoma

Non-Hodgkin lymphoma (NHL) may refer to any lymphoma (cancer of the lymph system) that is not Hodgkin lymphoma. The lymph system is a network of lymph tissue connected by vessels. The lymph system is separate from the blood circulatory system. The main types of cells in lymph tissue are lymphocytes which are white blood cells that fight bacteria, viruses and other foreign cells. Lymph tissue includes lymph nodes as well as knots of lymphocytes found in the intestines, spleen and bone marrow. Lymphoma occurs when lymphocytes begin to multiply uncontrollably or become cancerous. These cancerous cells can invade other parts of the body or metastasize. Non-Hodgkin lymphoma is more common than Hodgkin lymphoma. There are different types of NHL depending on if the cancer began in B-cells or T-cells as well as other characteristics.

Symptoms of NHL may include a swelling of the lymph nodes, unexplained fever, night sweats, weight loss, fatigue, and itching. In general the cause of non-Hodgkin lymphomas is unknown. NHL is more common in males and Caucasians. The risk of developing NHL increases with age, certain viral and bacterial infections and exposure to environmental exposure to certain chemicals and pesticides. NHL more often occurs in persons with an autoimmune disease or weakened immune systems such as those with HIV/AIDS or those who have undergone a transplant.

Lymphomas are generally diagnosed through a biopsy of the lymph nodes and sometimes a biopsy of the bone marrow. Other tests may be performed to determine where the cancer is located and how far it has spread. Treatment is similar to that of other cancers and may include radiation, chemotherapy, targeted therapy or a stem cell transplant. Treatment and prognosis depend upon the type and stage of NHL. If you or a family member has been diagnosed with non-Hodgkin lymphoma, talk with your doctor and specialists about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Non-Hodgkin lymphoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Non-Hodgkin lymphoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Non-Hodgkin lymphoma" returned 980 free, full-text research articles on human participants. First 3 results:

Non-Hodgkin lymphoma of multiple extranodal involvement seen on MRI, FDG PET-CT scans: A case report.
 

Author(s): Shan Wang, Meng Meng, Qiuhu Wang, Kai Xu

Journal: Medicine (Baltimore). 2017 Nov;96(45):e8456.

 

Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma (NHL). The most common extranodal sites of ALCL are skin, subcutaneous tissue, bone, lung, and gastrointestinal organs. This study reports a case of ALCL with multiple extranodal involvement, especially the ...

Last Updated: 31 Dec 1969

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Sleep quality and health-related quality of life among long-term survivors of (non-) Hodgkin lymphoma in Germany.
 

Author(s): Friederike Hammersen, Philip Lewin, Judith Gebauer, Ilonka Kreitschmann-Andermahr, Georg Brabant, Alexander Katalinic, Annika Waldmann

Journal:

 

This study investigated sleep quality and health-related quality of life (HRQOL) among long-term survivors of Hodgkin (HL) and non-Hodgkin lymphoma (NHL). The aim was to explore the impact of personal and health-related factors on sleep quality as well as associations between sleep ...

Last Updated: 31 Dec 1969

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Creation of a pediatric mature B-cell non-Hodgkin lymphoma cohort within the Pediatric Health Information System Database.
 

Author(s): Rebecca Citrin, Joseph P Horowitz, Anne F Reilly, Yimei Li, Yuan-Shung Huang, Kelly D Getz, Alix E Seif, Brian T Fisher, Richard Aplenc

Journal:

 

Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a collection of relatively rare pediatric malignancies. In order to utilize administrative data to perform large-scale epidemiologic studies within this population, a two-step process was used to assemble a 12-year cohort of B-NHL ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Non-Hodgkin lymphoma" returned 85 free, full-text review articles on human participants. First 3 results:

PI3Kδ-selective and PI3Kα/δ-combinatorial inhibitors in clinical development for B-cell non-Hodgkin lymphoma.
 

Author(s): Benjamin L Lampson, Jennifer R Brown

Journal: Expert Opin Investig Drugs. 2017 Nov;26(11):1267-1279.

 

The efficacy of the prototypical phosphatidylinositol-3-kinase (PI3K) inhibitor idelalisib for the treatment of chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin lymphoma (iNHL) has led to development of multiple compounds targeting this pathway. Areas Covered: We review ...

Last Updated: 31 Dec 1969

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Model-based meta-analysis of progression-free survival in non-Hodgkin lymphoma patients.
 

Author(s): Mengyao Li, Nimita Dave, Ahmed Hamed Salem, Kevin J Freise

Journal: Medicine (Baltimore). 2017 Sep;96(35):e7988.

 

Non-Hodgkin lymphoma (NHL) is a group of lymphoproliferative malignancies with varying treatment responses and progression-free survival (PFS) times. The objective of this study was to quantify the effect of treatment and patient-population characteristics on PFS in patients with NHL.

Last Updated: 31 Dec 1969

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Age and Sex in Non-Hodgkin Lymphoma Therapy: It's Not All Created Equal, or Is It?
 

Author(s): Michael Pfreundschuh

Journal: Am Soc Clin Oncol Educ Book. 2017 ;37():505-511.

 

Age is the most prominent factor for survival in all patients diagnosed with lymphoma, and male sex implies an increased and independent risk for a worse progression-free survival (PFS) and overall survival (OS) in most lymphomas, possibly with the exception of mantle cell lymphoma ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Chiauranib in Relapsed/Refractory Non-Hodgkin's Lymphoma
 

Status: Recruiting

Condition Summary: Non-Hodgkin's Lymphoma

 

Last Updated: 23 May 2017

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Last Updated: 22 Nov 2017

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Last Updated: 15 Nov 2017

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