Obsessive Compulsive Disorder

Common Name(s)

Obsessive Compulsive Disorder, OCD

Obsessive-compulsive disorder (OCD) is a lifelong condition where unreasonable thoughts and fears, or obsessions, lead a person to do repetitive behaviors, or compulsions. A person with OCD may or may not realize that their obsessions are unreasonable. A primary symptom of OCD is the presence of obsessions, which are repeated, persistent and unwanted urges that cause distress or anxiety. OCD obsessions often center on themes, such as fear of contamination, having things orderly/symmetric, or thoughts regarding harming oneself or others. Another symptom is the presence of compulsions, which are repetitive behavior that a person with OCD feels like they have to perform. Completing these repetitive behaviors are meant to prevent or reduce anxiety and prevent something bad from happening. Compulsions also follow themes like washing and cleaning, counting, checking, demanding reassurances and following a routine. Usually OCD is made up of both obsessions and compulsions, but it’s possible to only experience one. The general criteria to diagnose OCD is the person has obsessions and/or compulsions and these obsessions/compulsions are time-consuming and interfere with daily life. OCD has no cure, but symptoms can be controlled using exposure therapy and medication.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Obsessive Compulsive Disorder" for support, advocacy or research.

International OCD Foundation

Founded by a group of people with OCD in 1986, the International OCD Foundation (IOCDF) is an international not-for-profit organization made up of people with Obsessive Compulsive Disorder (OCD) and related disorders, as well as their families, friends, professionals and others. The mission and goals of the IOCDF are to: Educate the public and professionals about OCD in order to raise awareness and improve the quality of treatment provided; Support research into the cause of, and effective treatments for, OCD and related disorders; Improve access to resources for those with OCD and their fam

Last Updated: 19 Feb 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Obsessive Compulsive Disorder" for support, advocacy or research.

International OCD Foundation

Founded by a group of people with OCD in 1986, the International OCD Foundation (IOCDF) is an international not-for-profit organization made up of people with Obsessive Compulsive Disorder (OCD) and related disorders, as well as their families, friends, professionals and others. The mission and goals of the IOCDF are to: Educate the public and professionals about OCD in order to raise awareness and improve the quality of treatment provided; Support research into the cause of, and effective treatments for, OCD and related disorders; Improve access to resources for those with OCD and their fam

http://www.ocfoundation.org

Last Updated: 19 Feb 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Obsessive Compulsive Disorder" returned 715 free, full-text research articles on human participants. First 3 results:

Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population.
 

Author(s): Hae Won Kim, Jee In Kang, Eun Hee Hwang, Se Joo Kim

Journal:

 

Accumulating evidence suggests that the glutamatergic system plays a major role in the pathophysiology of obsessive compulsive disorder (OCD) and empathic processing. Particularly, genetic influence of glutamate transporter gene (SLC1A1) on OCD has been frequently replicated in previous ...

Last Updated: 31 Dec 1969

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Electroconvulsive therapy for manic state with mixed and psychotic features in a teenager with bipolar disorder and comorbid episodic obsessive-compulsive disorder: a case report.
 

Author(s): Olof Rask, Klara Suneson, Eva Holmström, Beata Bäckström, Björn Axel Johansson

Journal:

 

Comorbidity of bipolar disorder and obsessive-compulsive disorder is common in adolescence. Obsessive-compulsive disorder symptoms may be episodic and secondary to alterations in mood, and display specific features. Management of pediatric bipolar disorder-obsessive-compulsive disorder ...

Last Updated: 31 Dec 1969

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Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.
 

Author(s): Hyun Ji Noh, Ruqi Tang, Jason Flannick, Colm O'Dushlaine, Ross Swofford, Daniel Howrigan, Diane P Genereux, Jeremy Johnson, Gerard van Grootheest, Edna Grünblatt, Erik Andersson, Diana R Djurfeldt, Paresh D Patel, Michele Koltookian, Christina M Hultman, Michele T Pato, Carlos N Pato, Steven A Rasmussen, Michael A Jenike, Gregory L Hanna, S Evelyn Stewart, James A Knowles, Stephan Ruhrmann, Hans-Jörgen Grabe, Michael Wagner, Christian Rück, Carol A Mathews, Susanne Walitza, Daniëlle C Cath, Guoping Feng, Elinor K Karlsson, Kerstin Lindblad-Toh

Journal:

 

Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Obsessive Compulsive Disorder" returned 130 free, full-text review articles on human participants. First 3 results:

Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials.
 

Author(s): Neeltje M Batelaan, Renske C Bosman, Anna Muntingh, Willemijn D Scholten, Klaas M Huijbregts, Anton J L M van Balkom

Journal:

 

 To examine the risk of relapse and time to relapse after discontinuation of antidepressants in patients with anxiety disorder who responded to antidepressants, and to explore whether relapse risk is related to type of anxiety disorder, type of antidepressant, ...

Last Updated: 31 Dec 1969

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Quality of Life in Children with Obsessive-Compulsive Disorder.
 

Author(s): Joana Vieira, Filipa Ramalho E Silva

Journal: Acta Med Port. 2016 Sep;29(9):549-555.

 

Obsessive-compulsive disorder is a psychiatric disorder stated as one of the most debilitating diseases in the developedworld. However, not much is known about how this disease impairs patients' quality of life in children.

Last Updated: 31 Dec 1969

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Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis.
 

Author(s): Petros Skapinakis, Deborah M Caldwell, William Hollingworth, Peter Bryden, Naomi A Fineberg, Paul Salkovskis, Nicky J Welton, Helen Baxter, David Kessler, Rachel Churchill, Glyn Lewis

Journal: Lancet Psychiatry. 2016 Aug;3(8):730-739.

 

Several interventions are available for management of obsessive-compulsive disorder in adults, but few studies have compared their relative efficacy in a single analysis. We aimed to simultaneously compare all available treatments using both direct and indirect data.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pharmacogenetic Study of Obsessive-Compulsive Disorder
 

Status: Recruiting

Condition Summary: Obsessive-Compulsive Disorder

 

Last Updated: 24 Apr 2017

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Transcranial Direct Current Stimulation (tDCS) for Treatment-Resistant Obsessive-Compulsive Disorder (FRONT)
 

Status: Recruiting

Condition Summary: Obsessive-Compulsive Disorder

 

Last Updated: 30 May 2017

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Deep Brain Stimulation of NAc/ALIC to Prevent Treatment-Refractory Obsessive Compulsive Disorder
 

Status: Not yet recruiting

Condition Summary: Obsessive Compulsive Disorder

 

Last Updated: 9 Nov 2015

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