Ocular toxoplasmosis

Common Name(s)

Ocular toxoplasmosis

Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii.  Toxoplasmosis is the most common cause of eye inflammation in the world.  Toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus.  Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months.  In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease.   

Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common.   A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms.  However, the inactive parasite may later reactivate causing the ocular presentation of eye pain, blurred vision, and possibly permanent damage, including blindness.  Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.
 

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Condition Specific Organizations

Following organizations serve the condition "Ocular toxoplasmosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ocular toxoplasmosis" returned 116 free, full-text research articles on human participants. First 3 results:

Surgical outcomes of rhegmatogenous retinal detachment associated with ocular toxoplasmosis.
 

Author(s): Francisco Virmond Moreira, Andressa Moreira Iwanusk, Augusto Radünz do Amaral, Mário Junqueira Nóbrega, Fernando José De Novelli

Journal: Arq Bras Oftalmol. ;81(4):281-285.

 

To evaluate the anatomical and functional outcomes of surgical treatment of retinal detachment secondary to ocular toxoplasmosis.

Last Updated: 31 Dec 1969

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Serologic Tests of IgG and IgM Antibodies and IgG Avidity for Diagnosis of Ocular Toxoplasmosis.
 

Author(s): Bahman Rahimi-Esboei, Mohammad Zarei, Mehdi Mohebali, Hossein Keshavarz Valian, Saeedeh Shojaee, Raziyeh Mahmoudzadeh, Mirataollah Salabati

Journal: Korean J. Parasitol.. 2018 Apr;56(2):147-152.

 

This prospective study was aimed to detect acute and chronic ocular toxoplasmosis by comparison of anti- IgM and IgG antibody levels and IgG avidity test. One hundred and seventeen patients with ocular toxoplasmosis (OT) who referred to the Farabi Eye Hospital, Tehran, Iran were included ...

Last Updated: 31 Dec 1969

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Patterns of ocular toxoplasmosis presenting at a tertiary eye care center in Korean patients.
 

Author(s): Mirinae Kim, Seung Yong Choi, Jae Yon Won, Young-Hoon Park

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0399.

 

The objective of this study was to describe demographic and clinical features of ocular toxoplasmosis (OT) in Korean patients compared to those in other countries.This retrospective study comprised 46 patients diagnosed with OT. All participants were recruited at the uveitis clinic ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ocular toxoplasmosis" returned 18 free, full-text review articles on human participants. First 3 results:

Corticosteroids as adjuvant therapy for ocular toxoplasmosis.
 

Author(s): Smitha Jasper, Satyanarayana S Vedula, Sheeja S John, Saban Horo, Yasir J Sepah, Quan Dong Nguyen

Journal:

 

Ocular infection caused by Toxoplasma gondii, a parasite, may result in inflammation in the retina, choroid, and uvea, and consequently lead to complications such as glaucoma, cataract, and posterior synechiae.

Last Updated: 31 Dec 1969

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Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis.
 

Author(s): Cem Ozgonul, Cagri Giray Besirli

Journal: Ophthalmic Res.. 2017 ;57(1):1-12.

 

Ocular toxoplasmosis, a chorioretinal infection with Toxoplasma gondii, is the most common etiology of posterior uveitis in many countries. Accurate diagnosis depends heavily on the characteristic clinical features of this disease, but atypical presentations, especially in immunocompromised ...

Last Updated: 31 Dec 1969

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Ocular toxoplasmosis: recent aspects of pathophysiology and clinical implications.
 

Author(s): Uwe Pleyer, Dirk Schlüter, Martin Mänz

Journal: Ophthalmic Res.. 2014 ;52(3):116-23.

 

Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis
 

Status: Recruiting

Condition Summary: Toxoplasmosis Infection; Genotype II; Ocular Toxoplasmosis With Recurrences

 

Last Updated: 24 Aug 2018

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