Oligodendroglioma

Common Name(s)

Oligodendroglioma

Oligodendroglioma is a rare tumor that begins in oligodendrocytes, one of the types of cells that make up the supportive, or glial, tissue of the brain. They can be classified as low grade (grade II) or high grade (grade III) which refers to the how abnormal the tumor cells appear and suggests how fast the tumor may grow or spread. Type III is more aggressive than type II. This type of tumor can be found anywhere in the brain but are most commonly found in the frontal or temporal lobes (front or side of the brain). Symptoms vary depending on the size and location of the tumor but may include headaches, seizures, personality changes, one-sided weakness, and difficulty with short-term memory. Vision problems have also been reported due to added pressure on the brain. Tumors located in the temporal lobes often do not show symptoms for a long time. In general, these types of tumors are considered slow-growing so symptoms may not arise long after it begins to grow.

The cause of oligodendroglioma is not fully known, but both genetics and exposure to radiation are potential links to the development of the tumor. The majority of these tumors do no develop until mid-life, around 40 to 50 years old. Diagnosis may be made through a CT or MRI scan, a biopsy, or a combination of these methods. Treatment varies depending on the type, size, and placement of the tumor, but may include surgery, chemotherapy, radiation, steroids, or other medications. Talk to your doctor if you think you or your child may have oligodendroglioma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Oligodendroglioma" returned 104 free, full-text research articles on human participants. First 3 results:

Multimodal 18F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma.
 

Author(s): Anna Karlberg, Erik Magnus Berntsen, Håkon Johansen, Mariane Myrthue, Anne Jarstein Skjulsvik, Ingerid Reinertsen, Morteza Esmaeili, Hong Yan Dai, Yiming Xiao, Hassan Rivaz, Per Borghammer, Ole Solheim, Live Eikenes

Journal: World Neurosurg. 2017 Dec;108():989.e1-989.e8.

 

Structural magnetic resonance imaging (MRI) and histopathologic tissue sampling are routinely performed as part of the diagnostic workup for patients with glioma. Because of the heterogeneous nature of gliomas, there is a risk of undergrading caused by histopathologic sampling errors. ...

Last Updated: 31 Dec 1969

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Pinpointing Cancer Stem Cells in Oligodendroglioma.
 

Author(s):

Journal: Cancer Discov. 2017 01;7(1):6.

 

Through single-cell RNA sequencing of low-grade oligodendrogliomas, researchers have identified a cell population featuring a gene expression signature similar to those of neural stem and progenitor cells. These cancer stem cells have enriched proliferative potential and may be responsible ...

Last Updated: 31 Dec 1969

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Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway.
 

Author(s): Jason T Huse, Matija Snuderl, David T W Jones, Carole D Brathwaite, Nolan Altman, Ehud Lavi, Richard Saffery, Alexandra Sexton-Oates, Ingmar Blumcke, David Capper, Matthias A Karajannis, Ryma Benayed, Lukas Chavez, Cheddhi Thomas, Jonathan Serrano, Laetitia Borsu, Marc Ladanyi, Marc K Rosenblum

Journal: Acta Neuropathol.. 2017 Mar;133(3):417-429.

 

Epileptogenic tumors affecting children and young adults are a morphologically diverse collection of neuroepithelial neoplasms that, as a group, exhibit varying levels of glial and/or neuronal differentiation. Recent advances in molecular profiling technology, including comprehensive ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Oligodendroglioma" returned 14 free, full-text review articles on human participants. First 3 results:

Imaging of oligodendroglioma.
 

Author(s): Marion Smits

Journal: Br J Radiol. 2016 ;89(1060):20150857.

 

Oligodendroglioma are glial tumours, predominantly occurring in adults. Their hallmark molecular feature is codeletion of the 1p and 19q chromosome arms, which is not only of diagnostic but also of prognostic and predictive relevance. On imaging, these tumours characteristically show ...

Last Updated: 31 Dec 1969

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Oligodendroglioma: pathology, molecular mechanisms and markers.
 

Author(s): Pieter Wesseling, Martin van den Bent, Arie Perry

Journal: Acta Neuropathol.. 2015 Jun;129(6):809-27.

 

For nearly a century, the diagnosis and grading of oligodendrogliomas and oligoastrocytomas has been based on histopathology alone. Roughly 20 years ago, the first glioma-associated molecular signature was found with complete chromosome 1p and 19q codeletion being particularly common ...

Last Updated: 31 Dec 1969

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Secondary oligodendroglioma after postoperative irradiation for medulloblastoma: a case report and review of the literature.
 

Author(s): Hong-Lin He, Ying-En Lee, Han-Jung Chen, Chao-Tien Hsu, Yu-Yi Huang, I-Wei Chang

Journal:

 

Medulloblastoma, a malignant, invasive embryonal tumor of the cerebellum, occurs most often in children. It has high metastatic potential and is usually treated by aggressive multimodal therapy, including surgery, chemotherapy and craniospinal irradiation. Multiple secondary tumors ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

NovoTTF-200A Device in Treating Patients With Newly Diagnosed High Risk Oligodendroglioma
 

Status: Not yet recruiting

Condition Summary: Anaplastic Oligodendroglioma; Oligoastrocytoma; Oligodendroglioma

 

Last Updated: 14 Dec 2017

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Multicenter Safety Trial Assessing an Innovative Tumor Molecular and Cellular Print Medical Device in Glioma
 

Status: Recruiting

Condition Summary: Glioma : Oligodendroglioma or Astrocytoma

 

Last Updated: 30 Aug 2016

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