Osteoarthritis

Common Name(s)

Osteoarthritis

Osteoarthritis is one of the most common forms of arthritis. It is a chronic condition in which the material that cushions the joints, called cartilage, breaks down. This causes the bones to rub against each other, causing stiffness, pain and loss of joint movement. Common symptoms are sore or stiff joints, particularly the hips, knees, and lower back, but osteoarthritis may also affect the neck, small finger joints, the base of the thumb, ankle, and big toe. The pain may be moderate and come and go, without affecting the ability to perform daily tasks. Some people’s OA will never progress past this early stage. Others will have their OA get worse. The pain and stiffness of more severe osteoarthritis may make it difficult to walk, climb stairs, sleep, or perform other daily tasks.

About 27 million people in the United States have osteoarthritis. The cause is not fully understood and no cure exists but osteoarthritis treatments can slow the progression of the disease, relieve pain and improve joint function. Common risk factors include increasing age, obesity, previous joint injury, overuse of the joint, weak thigh muscles, and genetics.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteoarthritis" returned 5533 free, full-text research articles on human participants. First 3 results:

Clinical interest of quantitative bone SPECT-CT in the preoperative assessment of knee osteoarthritis.
 

Author(s): Romain De Laroche, Erwan Simon, Nicolas Suignard, Thomas Williams, Marc-Pierre Henry, Philippe Robin, Ronan Abgral, David Bourhis, Pierre-Yves Salaun, Frédéric Dubrana, Solène Querellou

Journal: Medicine (Baltimore). 2018 Aug;97(35):e11943.

 

The aim of the study was to evaluate the interest of quantitative bone SPECT-CT in the preoperative assessment of knee osteoarthritis (OA) before unicompartmental knee arthroplasty (UKA).Patients eligible for UKA were prospectively included in 2 centers and underwent a preoperative ...

Last Updated: 31 Dec 1969

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The Protective Effect of Ligustilide in Osteoarthritis: An in Vitro and in Vivo Study.
 

Author(s): Xiaobin Li, Dengying Wu, Zhichao Hu, Jiangwei Xuan, Xiaoxia Ding, Gang Zheng, Zhenhua Feng, Wenfei Ni, Aimin Wu

Journal: Cell. Physiol. Biochem.. 2018 ;48(6):2583-2595.

 

Osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and a chondrocyte inflammatory response that induces an inflammatory environment closely linked to extracellular matrix (ECM) degradation. Ligustilide (LIG) is a major component of the herb Radix ...

Last Updated: 31 Dec 1969

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MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway.
 

Author(s): Wei Zhang, Peichun Hsu, Biao Zhong, Shang Guo, Chi Zhang, Yukai Wang, Congfeng Luo, Yulin Zhan, Changqing Zhang

Journal: Cell. Physiol. Biochem.. 2018 ;48(3):1304-1316.

 

Osteoarthritis (OA) is the prevalent degenerative disease caused by various factors. MicroRNAs are important regulators in the inflammation and immune response. The aim of this study was to investigate the effect of microRNA-34a (MiR-34a) on the death of chondrocytes, senescence, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteoarthritis" returned 914 free, full-text review articles on human participants. First 3 results:

Bone quality, and the combination and penetration of cement-bone interface: A comparative micro-CT study of osteoarthritis and rheumatoid arthritis.
 

Author(s): Yuanzheng Song, Fahao Zhu, Feng Lin, Feng Zhang, Shuaigong Zhang

Journal: Medicine (Baltimore). 2018 Aug;97(35):e11987.

 

To compare the microstructure, bone quality, and the combination and penetration of cement-bone interface in tissue specimens from patients with osteoarthritis (OA) and rheumatoid arthritis (RA).A total of 80 femoral condyle tissue specimens from 20 OA patients (40 condyles) and 20 ...

Last Updated: 31 Dec 1969

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Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review.
 

Author(s): T A Rodrigues, A O Freire, B F Bonfim, M S S Cartágenes, J B S Garcia

Journal: Braz. J. Med. Biol. Res.. 2018 ;51(8):e7440.

 

Considering that osteoarthritis (OA) is the most prevalent joint disease worldwide, multiple pharmacological treatments have been proposed to alter the articular structure with potential benefit in the progression of the disease. The so-called disease-modifying OA drugs have been ...

Last Updated: 31 Dec 1969

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Function scores of different surgeries in the treatment of knee osteoarthritis: A PRISMA-compliant systematic review and network-meta analysis.
 

Author(s): Cheng-Yao Liu, Chuan-Dong Li, Liang Wang, Shan Ren, Fu-Bin Yu, Jin-Guang Li, Jiang-Xiong Ma, Xing-Long Ma

Journal: Medicine (Baltimore). 2018 May;97(21):e10828.

 

Osteoarthritis (OA) is the third most common diagnosis made by general practitioners in older patients. The aim of this study was to compare the function scores of different surgeries in the treatment of knee osteoarthritis (KOA).

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Feasibility of High Intensity Interval Training in Knee Osteoarthritis
 

Status: Recruiting

Condition Summary: Knee Osteoarthritis

 

Last Updated: 11 Dec 2017

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The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients
 

Status: Recruiting

Condition Summary: Osteoarthritis Hand

 

Last Updated: 24 Feb 2017

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Clinical Trial of YYD302 (Phase3) for Treatment of Osteoarthritis of the Knee
 

Status: Recruiting

Condition Summary: Osteoarthritis, Knee

 

Last Updated: 17 Jun 2018

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