Osteonecrosis

Common Name(s)

Osteonecrosis

Osteonecrosis is a disease caused by reduced blood flow to the bones. In healthy people, new bone is constantly growing to replace old bone. In people affected by osteonecrosis, new bone is not able to grow and replace old bones because of the reduced blood supply. This leads to a reduction in the amount of bone, which causes pain and limits mobility in joints. Osteonecrosis can affect anyone, but people who are between age 30-50 are most often affected.

The cause of osteonecrosis is reduced blood flow, but the cause of the reduction in blood flow is not always known. Some common causes include alcohol use, steroid medications, injury, and increased pressure in the bones. Major risk factors for osteonecrosis include having undergone chemotherapy and radiation treatments and having had an organ transplant. Certain diseases, such as cancer, lupus, HIV, and many others, also increase the risk for osteonecrosis. Others will develop osteonecrosis due to unknown causes, even without these risk factors.

The symptoms of osteonecrosis are joint pain and, depending on the severity, inability to use a joint. The disease may show no symptoms at all in the early stages, and worsening pain will result as the disease progresses. Treatment is usually based around maintaining function of the affected joints. Without any treatment, the disease will cause progressive loss of mobility. Seeking treatment as soon as possible is important to maintain joint function. Research is currently being done to learn more about the disease. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteonecrosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteonecrosis" returned 668 free, full-text research articles on human participants. First 3 results:

Core decompression, lesion clearance and bone graft in combination with Tongluo Shenggu decoction for the treatment of osteonecrosis of the femoral head: A retrospective cohort study.
 

Author(s): Yang-Quan Hao, Hao Guo, Tian Zhu, Zhao-Chen Xu, Han-Deng Qi, Chao Lu, Pu-Wei Yuan

Journal: Medicine (Baltimore). 2018 Oct;97(41):e12674.

 

The aim of this study was to evaluate the clinical effect of core decompression (CD), lesion clearance, and bone graft in combination with Tongluo Shenggu decoction for the treatment of osteonecrosis of the femoral head (ONFH).A total of 75 patients (92 hips), with ONFH at Association ...

Last Updated: 31 Dec 1969

Go To URL
Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress.
 

Author(s): Gerardo Bosco, Giuliano Vezzani, Simona Mrakic Sposta, Alex Rizzato, Garrett Enten, Abdullah Abou-Samra, Sandro Malacrida, Silvia Quartesan, Alessandra Vezzoli, Enrico Camporesi

Journal: J Enzyme Inhib Med Chem. 2018 Dec;33(1):1501-1505.

 

Early stages of avascular necrosis of the femoral head (AVNFH) can be conservatively treated with hyperbaric oxygen therapy (HBOT). This study investigated how HBOT modulates inflammatory markers and reactive oxygen species (ROS) in patients with AVNFH. Twenty-three male patients ...

Last Updated: 31 Dec 1969

Go To URL
The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis.
 

Author(s): Yangquan Hao, Hao Guo, Zhaochen Xu, Handeng Qi, Yugui Wang, Chao Lu, Jie Liu, Puwei Yuan

Journal:

 

The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH).

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteonecrosis" returned 96 free, full-text review articles on human participants. First 3 results:

Association of MMP-8 rs2012390 and rs11225394 polymorphisms with osteonecrosis of the femoral head risks: Evidence from a meta-analysis.
 

Author(s): Liangbin Jiang, Chungang Zhang, Biaofang Wei

Journal: Medicine (Baltimore). 2018 Oct;97(41):e12753.

 

The association of MMP-8 rs2012390 and rs11225394 polymorphisms with osteonecrosis of the femoral head (ONFH) risks was investigated in several studies with conflicting results. We performed the meta-analysis to evaluate the association between them.

Last Updated: 31 Dec 1969

Go To URL
Chinese herbal medicine formulas as adjuvant therapy for osteonecrosis of the femoral head: A systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Qingwen Zhang, Fan Yang, Yaolong Chen, Haibin Wang, Delong Chen, Wei He, Peng Chen

Journal: Medicine (Baltimore). 2018 Sep;97(36):e12196.

 

Osteonecrosis of femoral head (ONFH) is a disabling clinical entity affecting mainly young adults. Although Chinese Herbal Medicine (CHM) has been widely used as an adjunct therapy for ONFH in China, its effectiveness is not well defined. The purpose of this systematic review is to ...

Last Updated: 31 Dec 1969

Go To URL
Bayesian Network Meta-Analysis of the Effectiveness of Various Interventions for Nontraumatic Osteonecrosis of the Femoral Head.
 

Author(s): Ji Wang, Jing Wang, Kai Zhang, Yanfang Wang, Xuanwen Bao

Journal:

 

To assess the effectiveness of various therapeutic hip preservation strategies on patients with nontraumatic osteonecrosis of the femoral head (ONFH).

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 17 Apr 2018

Go to URL
The British Osteonecrosis Study
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 12 Mar 2018

Go to URL
Use of Adipose Derived Regenerative Cells in Bilateral Femoral Head Osteonecrosis
 

Status: Recruiting

Condition Summary: Osteonecrosis

 

Last Updated: 31 Oct 2018

Go to URL