Osteoporosis

Common Name(s)

Osteoporosis

Osteoporosis is a condition that causes bones to become weak and brittle. Bone is living tissue that is constantly being broken down and replaced. When you are young, your body typically makes new bone faster than it breaks down old bone. This leads to dense bone mass (strong bones). When the creation of new bone is unable to keep up with the removal of old bone, they become weak and brittle. If osteoporosis is severe enough, a crack or break (fracture) within the bone can occur from something as minor as a fall or even from a normal action, like coughing. Symptoms of osteoporosis may include back pain, decrease in height, a hunched posture, and increased risk of bone fractures.

Most people reach their peak bone mass by their early 20s. Individuals with a high peak bone mass when they are young have a lower chance of developing osteoporosis as they age. Gender, age, and race are all risk factors for developing osteoporosis. Women, individuals who are white or of Asian descent, and the elderly have an increased risk of developing osteoporosis. Low calcium intake, eating disorders, and gastrointestinal surgery can also cause a greater risk for osteoporosis. Certain medications, especially steroids, as well as tobacco use, excessive alcohol consumption and a sedentary lifestyle all increase the risk for osteoporosis.

Specific types of X-ray images, called DXA scans, may be used to determine your bone density and diagnose osteoporosis. There are many forms of treatment, depending on the severity. It is important to talk to your doctor, if you or someone you know has been diagnosed with osteoporosis, to review the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoporosis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoporosis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteoporosis" returned 2482 free, full-text research articles on human participants. First 3 results:

Combination therapy of anabolic and nonbisphosphonates antiresorptive agents for the treatment of osteoporosis: A meta-analysis.
 

Author(s): Shenghan Lou, Lifan Wang, Yiwen Wang, Yunduo Jiang, Jingwei Liu, Yansong Wang

Journal: Medicine (Baltimore). 2017 Dec;96(52):e9534.

 

According to the mechanisms of action, combination therapy of anabolic and antiresorptive agents may produce more effect for the treatment of osteoporosis. However, the combination therapy of anabolic agents and bisphosphonates reports no benefit and even reduced the anabolic effects ...

Last Updated: 31 Dec 1969

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Romosozumab versus Alendronate and Fracture Risk in Women with Osteoporosis.
 

Author(s): Kenneth G Saag, Jeffrey Petersen, Andreas Grauer

Journal: N. Engl. J. Med.. 2018 01;378(2):195-196.

 

Last Updated: 31 Dec 1969

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Improvements in osteoporosis testing and care are found following the wide scale implementation of the Ontario Fracture Clinic Screening Program: An interrupted time series analysis.
 

Author(s): Dorcas E Beaton, Muhammad Mamdani, Hong Zheng, Susan Jaglal, Suzanne M Cadarette, Earl R Bogoch, Joanna E M Sale, Rebeka Sujic, Ravi Jain,

Journal: Medicine (Baltimore). 2017 Dec;96(48):e9012.

 

We evaluated a system-wide impact of a health intervention to improve treatment of osteoporosis after a fragility fracture. The intervention consisted of assigning a screening coordinator to selected fracture clinics to identify, educate, and follow up with fragility fracture patients ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteoporosis" returned 681 free, full-text review articles on human participants. First 3 results:

Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk: A meta-analysis.
 

Author(s): Ying-Chun Chen, Lin Zhang, Er-Nan Li, Li-Xiang Ding, Gen-Ai Zhang, Yu Hou, Wei Yuan

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9231.

 

Insulin-like growth factor-1 (IGF-1) plays an important role in the regulation of bone formation and mineralization. We aimed to perform a meta-analysis to assess the association of three IGF-1 single nucleotide polymorphisms (SNPs) rs35767, rs2288377, and rs5742612 with osteoporosis risk.

Last Updated: 31 Dec 1969

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MANAGEMENT OF ENDOCRINE DISEASE: Atypical femoral fractures: risks and benefits of long-term treatment of osteoporosis with anti-resorptive therapy.
 

Author(s): Robert A Adler

Journal: Eur. J. Endocrinol.. 2018 Mar;178(3):R81-R87.

 

Modern osteoporosis treatment began in the mid-1990s with the approval of amino-bisphosphonates, anti-resorptive agents that have been shown to decrease osteoporotic fracture risk by about half. In 2005, the first cases of atypical femoral fractures (AFF), occurring in the shaft of ...

Last Updated: 31 Dec 1969

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Efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: A systematic review and meta-analysis.
 

Author(s): Lihua Peng, Qian Luo, Hui Lu

Journal: Medicine (Baltimore). 2017 Dec;96(49):e8659.

 

Bazedoxifene may be promising to treat osteoporosis of postmenopausal women. We conducted a systematic review and meta-analysis to explore the efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Jogging in the Change of Osteoporosis
 

Status: Not yet recruiting

Condition Summary: Osteoporosis

 

Last Updated: 29 Nov 2017

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Multicenter Cohort Study on Osteoporosis
 

Status: Not yet recruiting

Condition Summary: Osteoporosis

 

Last Updated: 4 Nov 2016

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Last Updated: 15 Jun 2016

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