Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 2064 free, full-text research articles on human participants. First 3 results:

Pulmonary Metastases from Chondroblastic Osteosarcoma.
 

Author(s): Hirva Mamdani, Sara J Grethlein

Journal: N. Engl. J. Med.. 2018 Apr;378(15):1429.

 

Last Updated: 31 Dec 1969

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miR-194 Suppresses Proliferation and Migration and Promotes Apoptosis of Osteosarcoma Cells by Targeting CDH2.
 

Author(s): Jinglei Miao, Weiguo Wang, Song Wu, Xiaofang Zang, Yuezhan Li, Jianlong Wang, Ruisen Zhan, Minwei Gao, Minghua Hu, Jinsong Li, Shijie Chen

Journal: Cell. Physiol. Biochem.. 2018 ;45(5):1966-1974.

 

Studies have shown that miR-194 functions as a tumour suppressor and is associated with tumour growth and metastasis. This study intends to uncover the mechanism of tumour suppression by miR-194. The expression of miR-194 in osteosarcoma cell lines and tissues were monitored by real-time PCR.

Last Updated: 31 Dec 1969

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Overexpression of Long Non-Coding RNA NNT-AS1 Correlates with Tumor Progression and Poor Prognosis in Osteosarcoma.
 

Author(s): Hui Ye, Jinkuang Lin, Xuedong Yao, Yizhong Li, Xiaobin Lin, Hai Lu

Journal: Cell. Physiol. Biochem.. 2018 ;45(5):1904-1914.

 

Increasing evidence demonstrates that long non-coding RNAs (lncRNAs) play critical regulatory roles in cancers, including osteosarcoma. A previous study showed that Nicotinamide Nucleotide Transhydrogenase-antisense RNA1 (NNT-AS1) was aberrantly expressed in several types of cancer. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 109 free, full-text review articles on human participants. First 3 results:

Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma.
 

Author(s): Yucheng Fu, Tao Lan, Hongliu Cai, Anwei Lu, Wei Yu

Journal: Medicine (Baltimore). 2018 May;97(19):e0741.

 

A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the result is still controversial and no consensus has been reached. Therefore, we performed a meta-analysis to evaluate the prognostic role ...

Last Updated: 31 Dec 1969

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Primary osteosarcoma of frontal bone: A case report and review of literature.
 

Author(s): Guangyong Wu, Qi Liang, Yu Liu

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9392.

 

Primary osteosarcomas of the skull and skull base are rare, comprising <2% of all skull tumors. Primary osteosarcomas of the skull are aggressive neoplasms composed of spindle cells producing osteoid which have poor outcome.

Last Updated: 31 Dec 1969

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Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics.
 

Author(s): Siobhan Simpson, Mark David Dunning, Simone de Brot, Llorenç Grau-Roma, Nigel Patrick Mongan, Catrin Sian Rutland

Journal:

 

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA survival rates in people not having improved in decades. For dogs, 1 year survival rates are only ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Osteosarcoma Biobank in Peking University People's Hospital
 

Status: Not yet recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 2 Dec 2017

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Biology of Osteosarcoma (BOOST) Registry and Biobank
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 21 Jul 2017

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A Phase II Trial of Avelumab in Patients With Recurrent or Progressive Osteosarcoma
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 27 Mar 2018

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