Osteosarcoma

Common Name(s)

Osteosarcoma

Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal.  Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

View Details
Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteosarcoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Logo
Sarcoma Alliance

The Sarcoma Alliance strives to improve the lives of people affected by sarcoma through accurate diagnosis, improved access to care, guidance, education and support.

http://sarcomaalliance.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteosarcoma" returned 2104 free, full-text research articles on human participants. First 3 results:

Andrographolide Induces Autophagic Cell Death and Inhibits Invasion and Metastasis of Human Osteosarcoma Cells in An Autophagy-Dependent Manner.
 

Author(s): Ying Liu, Yan Zhang, Jilong Zou, Lixin Yan, Xiufeng Yu, Peng Lu, Xiaomeng Wu, Qiaozhi Li, Rui Gu, Daling Zhu

Journal: Cell. Physiol. Biochem.. 2017 ;44(4):1396-1410.

 

Osteosarcoma (OS) is the most common primary malignant tumor of bone tissue. Although treatment effectiveness has improved, the OS survival rate has fluctuated in recent years. Andrographolide (AG) has been reported to have antitumor activity against a variety of tumors. Our aim was ...

Last Updated: 31 Dec 1969

Go To URL
[Breast osteosarcoma originating in a phyllodes tumor. Report of one case].
 

Author(s): Tereza Nieto-Coronel, Jessica Elizabeth Salazar-Campos, David Cantú de León, Raúl Díaz-Molina, Rafael Vázquez-Romo, Enrique Bargalló-Rocha

Journal: Rev Med Chil. 2017 Aug;145(8):1076-1082.

 

Phyllodes tumors account for less than 1% of tumors of the mammary gland, have both epithelial and stromal components and are classified as benign, borderline and malignant. The malignant tumors are highly heterogeneous: they can differentiate to liposarcomas, fibrosarcomas, rhabdomyosarcomas, ...

Last Updated: 31 Dec 1969

Go To URL
Therapeutic effect of neoadjuvant chemotherapy combined with curettage to treat distal femoral osteosarcoma: A case report.
 

Author(s): Qi Lai, Conglin Ye, Tian Gao, Jun Xiao, An Xie, Xuqiang Liu, Xiaolong Yu, Jun Liu, Min Dai, Hucheng Liu, Bin Zhang

Journal: Medicine (Baltimore). 2017 Nov;96(46):e8672.

 

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Metastasis occurs early, the mortality rate is high, and the tumor results in a tremendous physical, mental, and economic burden on patients. Therefore, the treatment of osteosarcoma has been important ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteosarcoma" returned 118 free, full-text review articles on human participants. First 3 results:

Primary osteosarcoma of frontal bone: A case report and review of literature.
 

Author(s): Guangyong Wu, Qi Liang, Yu Liu

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9392.

 

Primary osteosarcomas of the skull and skull base are rare, comprising <2% of all skull tumors. Primary osteosarcomas of the skull are aggressive neoplasms composed of spindle cells producing osteoid which have poor outcome.

Last Updated: 31 Dec 1969

Go To URL
Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics.
 

Author(s): Siobhan Simpson, Mark David Dunning, Simone de Brot, Llorenç Grau-Roma, Nigel Patrick Mongan, Catrin Sian Rutland

Journal:

 

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA survival rates in people not having improved in decades. For dogs, 1 year survival rates are only ...

Last Updated: 31 Dec 1969

Go To URL
Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets.
 

Author(s): Zhihong Li, Pengcheng Dou, Tang Liu, Shasha He

Journal: Cell. Physiol. Biochem.. 2017 ;42(4):1407-1419.

 

Osteosarcoma is the most common primary bone malignancy in children and adolescents. Although improvements in therapeutic strategies were achieved, the outcome remains poor for most patients with metastatic or recurrent osteosarcoma. Therefore, it is imperative to identify novel and ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

The Osteosarcoma Biobank in Peking University People's Hospital
 

Status: Not yet recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 2 Dec 2017

Go to URL
Biology of Osteosarcoma (BOOST) Registry and Biobank
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 21 Jul 2017

Go to URL
A Phase II Trial of Avelumab in Patients With Recurrent or Progressive Osteosarcoma
 

Status: Recruiting

Condition Summary: Osteosarcoma

 

Last Updated: 24 Jan 2018

Go to URL