Polyarteritis nodosa

Common Name(s)

Polyarteritis nodosa, PAN

Polyarteritis nodosa (PAN) is a rare disease that causes redness and swelling (inflammation) of the medium sized tubes that carry blood around the body (blood vessels). This inflammation causes poor blood flow and leads to damage of affected organs. PAN most commonly affects the arteries in the skin, nerves, gut (intestinal tract), and kidneys. If only the skin is affected, it is called cutaneous PAN. If only one organ is affected, it is called localized PAN. Symptoms of PAN depend on the organ system involved. Symptoms may include general tiredness (fatigue), fever, loss of appetite, weight loss, pain in muscles or joints, skin sores, abdominal pain, blood in the stool, shortness of breath, chest pain, high blood pressure, and numbness. PAN can sometimes cause an increase in the size of part of a blood vessel (aneurysm), which can cause the vessel to break open (rupture).

The exact cause of PAN is unknown. Researchers believe it can be triggered by a reaction to a medication or a reaction to an infection (either bacterial or viral). These reactions are usually due to an issue with the body’s immune system. Men usually have PAN more often than women and people typically develop the condition between the ages of 40 and 60. Your doctor will use a combination of your symptoms, physical exam, blood tests and imaging tests (x-rays, MRIs and CTs) to diagnose PAN. In some cases, removal and examination of an affected area (biopsy) may be needed to confirm the diagnosis. Treatment of PAN varies, depending on the underlying cause and affected area. If you have been diagnosed with PAN, speak with your doctor to discuss the most current treatment options. Support groups are also a good source of additional information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polyarteritis nodosa" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polyarteritis nodosa" returned 230 free, full-text research articles on human participants. First 3 results:

Adalimumab therapy in hepatitis B virus-negative polyarteritis nodosa: A case report.
 

Author(s): Chrong-Reen Wang, Chao-Chun Yang

Journal: Medicine (Baltimore). 2018 Jun;97(25):e11053.

 

Polyarteritis nodosa (PAN) is a difficult-to-treat rheumatology disorder, and biologic agents have been used in such patients with a treatment failure or the disease relapse.

Last Updated: 31 Dec 1969

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Diagnosis of deficiency of adenosine deaminase 2 with early onset polyarteritis nodosa in an adult patient with a novel compound heterozygous CECR1 mutation.
 

Author(s): Peter Lamprecht, Jens Y Humrich, Isabel Diebold, Gabriela Riemekasten

Journal: Clin. Exp. Rheumatol.. ;36 Suppl 111(2):177.

 

Last Updated: 31 Dec 1969

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Cutaneous polyarteritis nodosa causing refractory skin deformation and pigmentation as sequel.
 

Author(s): Karin Okada, Rina Nakamori, Hitoshi Mizutani, Keiichi Yamanaka

Journal: An Bras Dermatol. 2017 ;92(5 Suppl 1):53-55.

 

A 39-year-old woman presented with prominent and painful livedo reticularis lesions spreading on her upper and lower extremities. Histopathologically, the small-to medium-sized arteries in the deep dermis and subcutis showed necrotizing vasculitis with cellular infiltration, suggesting ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polyarteritis nodosa" returned 17 free, full-text review articles on human participants. First 3 results:

Polyarteritis nodosa revisited: a review of historical approaches, subphenotypes and a research agenda.
 

Author(s): Omer Karadag, David J Jayne

Journal: Clin. Exp. Rheumatol.. ;36 Suppl 111(2):135-142.

 

Polyarteritis nodosa (PAN) is a rare form of primary systemic vasculitis with heterogeneous presentations, treatments and disease course. Historical approaches to classification and diagnostic terminology are reviewed. Since differentiation of PAN from microscopic polyangiitis (MPA) ...

Last Updated: 31 Dec 1969

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[Asynchronous Bilateral Testicular Infarction with Suspected Polyarteritis Nodosa : A Case Report].
 

Author(s): Masayuki Kurokawa, Sei Naito, Osamu Ichiyanagi, Aya Suto, Yuta Kurota, Toshihiko Sakurai, Hayato Nishida, Hisashi Kawazoe, Tomoyuki Kato, Akira Nagaoka, Hiromi Ito, Mitsunori Yamakawa, Norihiko Tsuchiya

Journal: Hinyokika Kiyo. 2016 Dec;62(12):657-660.

 

This report documents a case of asynchronous bilateral testicular infarction. The patient was a 42- year-old man who presented with left testicular pain and swelling. He had a past history of right idiopathic testicular infarction and underwent a right orchiectomy 6 years ago. He ...

Last Updated: 31 Dec 1969

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Polyarteritis nodosa.
 

Author(s): Travis Howard, Kinza Ahmad, Jerome Allen A Swanson, Sanjay Misra

Journal: Tech Vasc Interv Radiol. 2014 Dec;17(4):247-51.

 

The first description of polyarteritis nodosa (PAN) was in 1852 by Karl Rokitansky, a pathologist at the University of Vienna. The initial report describes a 23-year-old man who had a 5-day history of fever and diarrhea. Since then, the definition of PAN has evolved. The currently ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Determining Disease Activity Biomarkers in Individuals With Polyarteritis Nodosa
 

Status: Recruiting

Condition Summary: Polyarteritis Nodosa

 

Last Updated: 23 Apr 2018

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A Randomized Multicenter Study for Isolated Skin Vasculitis
 

Status: Recruiting

Condition Summary: Primary Cutaneous Vasculitis; Cutaneous Polyarteritis Nodosa; IgA Vasculitis; Henoch-Schönlein Purpura

 

Last Updated: 10 Apr 2018

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Pediatric Vasculitis Initiative
 

Status: Recruiting

Condition Summary: Wegeners Granulomatosis (Granulomatosis With Polyangiitis); Microscopic Polyangiitis; Churg Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis); Polyarteritis Nodosa; Takayasu Arteritis; Primary CNS Vasculitis; Unclassified Vasculitis

 

Last Updated: 3 May 2018

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