Premenstrual dysphoric disorder

Common Name(s)

Premenstrual dysphoric disorder, PMDD

Premenstrual dysphoric disorder (PMDD) is a hormone-based mood disorder that affects around 2-8% of women in their reproductive years. PMDD is directly related to a woman’s menstrual cycle with symptoms that occur just before menstruation, or 7 to 10 days before a woman’s period and often lasting through the first few days of her period. Although it is not a hormonal disorder, the cycle of hormone changes associated with the female reproductive cycle play a role in PMDD. Women with a personal or family history of mood disorders and depression are considered to be more at risk for PMDD.

Psychological and behavioral symptoms include sadness or depression, tension, panic attacks, anger and irritability, difficulty focusing, tiredness, food cravings, and trouble sleeping. Physical symptoms include bloating, breast tenderness, headaches, and joint and muscle pain. Mood shifts are more extreme than PMS, and feelings of sadness and hopelessness, anxiety or tension, and irritability or anger are much more pronounced. Symptoms of PMDD have a greater impact on daily life than symptoms of PMS. PMDD symptoms usually begin in a woman’s 20s but may start earlier.

Diagnosing PMDD involves a review of your medical history and symptoms, a physical exam, an exam by your gynecologist or midwife, and further testing to rule out hormonal disorders. A psychiatric examination should also be completed to look at other factors leading to PMDD-like symptoms that might not be related to the menstrual cycle. Treatment for PMDD may include antidepressants, birth control, and changes in lifestyle and diet, including nutritional supplements. If you have been diagnosed with PPMD, talk to your gynecologist or midwife about the most current treatment options. Support groups are a good source of information and can connect you with other women who are living with PMDD.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premenstrual dysphoric disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Premenstrual dysphoric disorder" returned 56 free, full-text research articles on human participants. First 3 results:

The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder.
 

Author(s): N Dubey, J F Hoffman, K Schuebel, Q Yuan, P E Martinez, L K Nieman, D R Rubinow, P J Schmidt, D Goldman

Journal: Mol. Psychiatry. 2017 Aug;22(8):1172-1184.

 

Clinical evidence suggests that mood and behavioral symptoms in premenstrual dysphoric disorder (PMDD), a common, recently recognized, psychiatric condition among women, reflect abnormal responsivity to ovarian steroids. This differential sensitivity could be due to an unrecognized ...

Last Updated: 3 Jan 2017

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Association of premenstrual syndrome and premenstrual dysphoric disorder with bulimia nervosa and binge-eating disorder in a nationally representative epidemiological sample.
 

Author(s): Carrie J Nobles, Jennifer J Thomas, Sarah E Valentine, Monica W Gerber, Adin S Vaewsorn, Luana Marques

Journal: Int J Eat Disord. 2016 07;49(7):641-50.

 

Bulimia nervosa (BN) and binge-eating disorder (BED) are associated with significant health impairment. Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) comprise both psychological (disturbances in mood and affect) and physiological (bloating and changes in appetite) ...

Last Updated: 12 Jul 2016

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Treating comorbid premenstrual dysphoric disorder in women with bipolar disorder.
 

Author(s): Mara Smith, Benicio N Frey

Journal: J Psychiatry Neurosci. 2016 Mar;41(2):E22-3.

 

Last Updated: 22 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Premenstrual dysphoric disorder" returned 11 free, full-text review articles on human participants. First 3 results:

Premenstrual Syndrome and Premenstrual Dysphoric Disorder.
 

Author(s): Sabrina Hofmeister, Seth Bodden

Journal: Am Fam Physician. 2016 Aug;94(3):236-40.

 

Premenstrual disorders affect up to 12% of women. The subspecialties of psychiatry and gynecology have developed overlapping but distinct diagnoses that qualify as a premenstrual disorder; these include premenstrual syndrome and premenstrual dysphoric disorder. These conditions encompass ...

Last Updated: 2 Aug 2016

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Premenstrual Dysphoric Disorder: Epidemiology and Treatment.
 

Author(s): Liisa Hantsoo, C Neill Epperson

Journal: Curr Psychiatry Rep. 2015 Nov;17(11):87.

 

Recently designated as a disorder in the DSM-5, premenstrual dysphoric disorder (PMDD) presents an array of avenues for further research. PMDD's profile, characterized by cognitive-affective symptoms during the premenstruum, is unique from that of other affective disorders in its ...

Last Updated: 17 Sep 2015

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Effects and treatment methods of acupuncture and herbal medicine for premenstrual syndrome/premenstrual dysphoric disorder: systematic review.
 

Author(s): Su Hee Jang, Dong Il Kim, Min-Sun Choi

Journal:

 

During their reproductive years about 10% of women experience some kind of symptoms before menstruation (PMS) in a degree that affects their quality of life (QOL). Acupuncture and herbal medicine has been a recent favorable therapeutic approach. Thus we aimed to review the effects ...

Last Updated: 17 Jan 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alternative Treatments for Premenstrual Dysphoric Disorder
 

Status: Recruiting

Condition Summary: Premenstrual Dysphoric Disorder

 

Last Updated: 15 Nov 2016

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Intranasal PH80 Spray for Acute Management of the Symptoms of Premenstrual Dysphoric Disorder
 

Status: Not yet recruiting

Condition Summary: Premenstrual Dysphoric Disorder

 

Last Updated: 1 Dec 2015

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