POEMS syndrome

Common Name(s)

POEMS syndrome

POEMS syndrome is a rare blood disorder. It is characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma proliferative disorder, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy, enlarged liver and spleen, swollen lymph nodes, and darkening of the skin. Further testing and evaluation may show plasma cell disorder and sclerotic bone lesions. Many people with POEMS syndrome have diabetes (20-50%) and primary gonadal failure (55-70%). Other general signs and symptoms may include increased body hair, thickening of the skin, whitening of the nails, fatigue, weakness, swelling of the ankles and legs, enlarged breast tissue, generalized aches and pains, fluid in the lungs, and vision changes. Sign and symptoms tend to begin in a person's 40's to 50's. POEMS syndrome is a rapidly progressive disorder that can become life threatening. Currently the exact cause of POEMS syndrome is unknown.  Researchers believe the syndrome involves an overgrowth of bone marrow cells (plasma cells), which produce chemicals that damage other parts of the body.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "POEMS syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "POEMS syndrome" returned 138 free, full-text research articles on human participants. First 3 results:

Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report.
 

Author(s): Daisuke Hara, Hisanao Akiyama, Saki Nukui, Takahiro Shimizu, Masahiro Hoshikawa, Yasuhiro Hasegawa

Journal: Medicine (Baltimore). 2017 Oct;96(41):e8188.

 

We report a case of successful diagnosis of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome based on monoclonality that was confirmed by an osteosclerotic lesion biopsy in a patient without pathognomonic symptoms or monoclonal ...

Last Updated: 11 Oct 2017

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Nerve pathologic features differentiate POEMS syndrome from CIDP.
 

Author(s): Ezequiel A Piccione, Janean Engelstad, Peter J Dyck, Michelle L Mauermann, Angela Dispenzieri, P James B Dyck

Journal:

 

The objective of this study is to determine if the nerve pathology in patients with POEMS syndrome is different from CIDP. We hypothesized that nerve biopsies from patients with POEMS syndrome would have more small vessels and axonal degeneration but less inflammation than CIDP.We ...

Last Updated: 1 Nov 2016

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High-dose therapy and autologous stem cell transplantation in patients with POEMS syndrome: a retrospective study of the Plasma Cell Disorder sub-committee of the Chronic Malignancy Working Party of the European Society for Blood & Marrow Transplantation.
 

Author(s): Gordon Cook, Simona Iacobelli, Anja van Biezen, Dimitris Ziagkos, Veronique LeBlond, Julie Abraham, Grant McQuaker, Stefan Schoenland, Alessandro Rambaldi, Kazimierz Halaburda, Maria Rovira, Simona Sica, Jenny Byrne, Ramon Garcia Sanz, Arnon Nagler, Niels W C J van de Donk, Marjatta Sinisalo, Mark Cook, Nicolaus Kröger, Theo De Witte, Curly Morris, Laurant Garderet

Journal: Haematologica. 2017 Jan;102(1):160-167.

 

POEMS syndrome is a rare para-neoplastic syndrome secondary to a plasma cell dyscrasia. Effective treatment can control the disease-related symptom complex. We describe the clinical outcome of autologous stem cell transplantation for patients with POEMS syndrome, determining the impact ...

Last Updated: 16 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "POEMS syndrome" returned 17 free, full-text review articles on human participants. First 3 results:

POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification.
 

Author(s): Nobuyuki Araki, Sonoko Misawa, Kazumoto Shibuya, Satoshi Ota, Takashi Oide, Asuka Kawano, Minako Beppu, Yukio Nakatani, Satoshi Kuwabara

Journal:

 

Calciphylaxis is a syndrome consisting of vascular calcification, thrombosis, and skin necrosis. The syndrome develops often in chronic hemodialysis patients. However, there have been several case reports on calciphylaxis in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, ...

Last Updated: 12 Apr 2016

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POEMS syndrome: update on diagnosis, risk-stratification, and management.
 

Author(s): Angela Dispenzieri

Journal: Am. J. Hematol.. 2015 Oct;90(10):951-62.

 

POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman ...

Last Updated: 21 Sep 2015

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POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) treated with autologous hematopoietic stem cell transplantation: a case report and literature review.
 

Author(s): Carlos Arana, José Antonio Pérez de León, Gerardo Gómez-Moreno, Ramón Pérez-Cano, Tomás Martín Hernández

Journal:

 

POEMS syndrome is a rare systemic pathology of paraneoplastic origin that is associated with plasma cell dyscrasia. It is characterized by the presence of sensorimotor polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes, and other systemic manifestations. ...

Last Updated: 2 Mar 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome
 

Status: Recruiting

Condition Summary: Plasmacytoma; POEMS Syndrome

 

Last Updated: 9 May 2017

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