Paraneoplastic Neurologic Disorders

Common Name(s)

Paraneoplastic Neurologic Disorders

Paraneoplastic neurologic disorders are a group of rare degenerative conditions that are triggered by a person's immune system response to a cancerous tumor. Researchers believe these disorders occur when cancer-fighting antibodies or white blood cells known as T cells mistakenly attack normal cells in the nervous system. Paraneoplastic neurologic disorders typically develop after mid-adulthood and are most common in people with lung, ovarian, lymphatic, or breast cancer. Symptoms generally develop over a period of days to weeks and usually occur prior to tumor detection. These symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. Paraneoplastic neurologic disorders include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis (inflammation of the brain and spinal cord), myasthenia gravis, cerebellar degeneration, limbic and/or brainstem encephalitis, neuromyotonia, and opsoclonus (involving eye movement) and sensory neuropathy.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Paraneoplastic Neurologic Disorders" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Paraneoplastic Neurologic Disorders" returned 4 free, full-text research articles on human participants. First 3 results:

Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study.
 

Author(s): Paul Gozzard, Mark Woodhall, Caroline Chapman, Anjan Nibber, Patrick Waters, Angela Vincent, Bethan Lang, Paul Maddison

Journal: Neurology. 2015 Jul;85(3):235-9.

 

To determine the frequency and range of paraneoplastic neurologic disorders (PNDs) and neuronal antibodies in small cell lung carcinoma (SCLC).

Last Updated: 31 Dec 1969

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Update on paraneoplastic neurologic disorders.
 

Author(s): Myrna R Rosenfeld, Josep Dalmau

Journal: Oncologist. 2010 ;15(6):603-17.

 

When patients with cancer develop neurologic symptoms, common causes include metastasis, infections, coagulopathy, metabolic or nutritional disturbances, and neurotoxicity from treatments. A thorough clinical history, temporal association with cancer therapies, and results of ancillary ...

Last Updated: 31 Dec 1969

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Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders.
 

Author(s): Josep Dalmau, Luis Bataller

Journal: Hematol. Oncol. Clin. North Am.. 2006 Dec;20(6):1319-35.

 

The most important contribution to the understanding and management of paraneoplastic neurologic disorders (PND) is the discovery that many of these diseases are immune mediated. It is believed that cytotoxic T-cell responses and antibodies that target neuronal proteins usually expressed ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Paraneoplastic Neurologic Disorders" returned 3 free, full-text review articles on human participants. First 3 results:

Diagnosis and management of paraneoplastic neurologic disorders.
 

Author(s): Myrna R Rosenfeld, Josep Dalmau

Journal: Curr Treat Options Oncol. 2013 Dec;14(4):528-38.

 

Paraneoplastic neurologic disorders (PND) are a heterogeneous group of immune-mediated neurological disorders associated with systemic cancers. When a PND is diagnosed, prompt identification and treatment of the associated tumor is important as PND stabilization and in some cases ...

Last Updated: 31 Dec 1969

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Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer.
 

Author(s): Iñigo Rojas-Marcos, Audrey Rousseau, Florence Keime-Guibert, Ramón Reñé, Stéphanie Cartalat-Carel, Jean Yves Delattre, Francesc Graus

Journal: Medicine (Baltimore). 2003 May;82(3):216-23.

 

We conducted the current review of the paraneoplastic neurologic syndromes (PNSs) associated with gynecologic and breast carcinomas to describe their clinical and immunologic characteristics and their relative frequency. We retrospectively reviewed 92 patients whose serum was sent ...

Last Updated: 31 Dec 1969

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Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.
 

Author(s): R B Darnell

Journal: Proc. Natl. Acad. Sci. U.S.A.. 1996 May;93(10):4529-36.

 

Paraneoplastic neurologic disorders (PNDs) are believed to be autoimmune neuronal degenerations that develop in some patients with systemic cancer. A series of genes encoding previously undiscovered neuronal proteins have been cloned using antiserum from PND patients. Identification ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Study of Immune Cell (T Cell) Activity in Patients With Paraneoplastic Neurologic Syndromes
 

Status: Recruiting

Condition Summary: Paraneoplastic Syndromes

 

Last Updated: 2 Jan 2018

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National Registry for Egyptian Pediatric Neuromuscular Diseases
 

Status: Recruiting

Condition Summary: Spinal Muscular Atrophy; Muscular Dystrophy; Muscle Diseases; Myasthenic Syndromes; Polyneuropathies

 

Last Updated: 25 Apr 2014

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The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders
 

Status: Recruiting

Condition Summary: Neuromyelitis Optica; Neuromyelitis Optica Spectrum Disorder; Transverse Myelitis; Optic Neuritis

 

Last Updated: 29 Dec 2017

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