Patent ductus arteriosus

Common Name(s)

Patent ductus arteriosus

Patent ductus arteriosus (PDA) is a common heart defect that occurs when the ductus arteriosis does not close shortly after birth. The ductus arteriosis is a fetal artery connecting the aorta and the pulmonary artery. When the artery is not closed properly, it acts as a detour by not sending all the blood to the lungs (fetal blood obtains oxygen from the placenta). After birth, oxygen poor blood needs to go to the lungs to obtain oxygen. If the ductus arteriosis does not close, it can cause both the lungs and the heart to work too hard. PDA is sometimes found with other heart defects or in certain genetic conditions such as Down syndrome. PDA appears to be more common in girls.

Usually PDA is diagnosed in infancy but if it is small, symptoms may only appear in childhood. Severity of symptoms depends on the size and whether other heart defects are also present. Symptoms may include poor feeding or sweating while feeding, shortness of breath, tiring easily, fast pulse and poor growth. The causes of PDA are likely a combination of genetics and environment. Risk factors include premature birth, being born at a high altitude, a rubella infection during pregnancy, or a family history of certain genetic conditions.

A heart murmur is usually heard in infancy, but may be missed in a premature baby. The diagnosis will be confirmed using X-rays and an electrocardiogram (EKG). Other tests may check for other possible heart defects. In premature babies, the opening may close on its own even after the first few days, so the PDA may just be watched. Treatment options include medication and surgery, and may not be necessary. Outlook is excellent if PDA occurs without any associated birth defects. Talk to your baby’s cardiologist about treatment and management options. If the PDA is part of a syndrome or runs in your family, talk to a genetic counselor. Support groups are a good source of information and can connect you to other families affected by PDA.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Patent ductus arteriosus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Patent ductus arteriosus" returned 502 free, full-text research articles on human participants. First 3 results:

Prospective observational study on assessing the hemodynamic relevance of patent ductus arteriosus with frequency domain near-infrared spectroscopy.
 

Author(s): Christoph E Schwarz, Antonio Preusche, Martin Wolf, Christian F Poets, Axel R Franz

Journal:

 

What constitutes a hemodynamically relevant patent ductus arteriosus (hrPDA) in preterm infants is unclear. Different clinical and echocardiographic parameters are used, but a gold standard definition is lacking. Our objective was to evaluate associations between regional cerebral ...

Last Updated: 31 Dec 1969

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An Infectious Pseudoaneurysm Caused by Ventricular Septal Defect Occluder in Patent Ductus Arteriosus Closure in a Two-Year-Old Child.
 

Author(s): Dingyang Li, Qiu Qiu, Jing Jin, Changdong Zhang, Lijun Wang, Gangcheng Zhang

Journal: Int Heart J. 2017 Dec;58(6):1017-1019.

 

We present a case of an infectious pseudoaneurysm after patent ductus arteriosus (PDA) closure with a ventricular septal defect (VSD) occluder in a two-year-old child. The aneurysm grew rapidly but was successfully removed in time and the patient survived. To our knowledge, this is ...

Last Updated: 31 Dec 1969

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Successful Pulmonary Artery Embolization for the Management of Hemoptysis in a Patient with Eisenmenger Syndrome Caused by Patent Ductus Arteriosus.
 

Author(s): Naoki Tamada, Kazuhiko Nakayama, Yuto Shinkura, Kenichi Yanaka, Naoto Katayama, Takuya Okada, Masato Yamaguchi, Kensuke Matsumoto, Hidekazu Tanaka, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata

Journal: Intern. Med.. 2017 Dec;56(24):3299-3304.

 

The patient was a 19-year-old woman who was diagnosed with patent ductus arteriosus complicating Eisenmenger syndrome at a previous medical institution. She was referred to our hospital and arranged for lung transplantation. She developed hemoptysis after the introduction of i.v. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Patent ductus arteriosus" returned 36 free, full-text review articles on human participants. First 3 results:

Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?
 

Author(s): Flaminia Bardanzellu, Paola Neroni, Angelica Dessì, Vassilios Fanos

Journal: Biomed Res Int. 2017 ;2017():1438038.

 

In preterm infants, failure or delay in spontaneous closure of Ductus Arteriosus (DA), resulting in the condition of Patent Ductus Arteriosus (PDA), represents a significant issue. A prolonged situation of PDA can be associated with several short- and long-term complications. Despite ...

Last Updated: 31 Dec 1969

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Percutaneous Patent Ductus Arteriosus (PDA) Closure During Infancy: A Meta-analysis.
 

Author(s): Carl H Backes, Brian K Rivera, Jeffrey A Bridge, Aimee K Armstrong, Brian A Boe, Darren P Berman, Tyler Fick, Ralf J Holzer, Ziyad M Hijazi, Sylvia Abadir, Henri Justino, Lisa Bergersen, Charles V Smith, Haresh Kirpalani

Journal: Pediatrics. 2017 Feb;139(2):.

 

Patent ductus arteriosus (PDA) is a precursor to morbidity and mortality. Percutaneous (catheter-based) closure is the procedure of choice for adults and older children with a PDA, but use during infancy (<1 year) is not well characterized.

Last Updated: 31 Dec 1969

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Effectiveness and safety of treatments used for the management of patent ductus arteriosus (PDA) in preterm infants: a protocol for a systematic review and network meta-analysis.
 

Author(s): Souvik Mitra, Ivan D Florez, Maria E Tamayo, Dagfinn Aune, Lawrence Mbuagbaw, Areti-Angeliki Veroniki, Lehana Thabane

Journal:

 

Management of patent ductus arteriosus (PDA) in preterm infants is one of the most controversial topics in neonatal medicine. The availability of different pharmacotherapeutic options often poses a practical challenge to the practising neonatologist as to which one to choose as a ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

IV Acetaminophen and Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 28 Jun 2017

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Near Infrared Spectroscopy to Determine Patent Ductus Arteriosus Closure
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 26 Jun 2018

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International Experience in Timing And Choices for Ductal Closure in Patent Ductus Arteriosus:INTERPDA Trial
 

Status: Not yet recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 20 Sep 2016

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