Patent ductus arteriosus

Common Name(s)

Patent ductus arteriosus

Patent ductus arteriosus (PDA) is a common heart defect that occurs when the ductus arteriosis does not close shortly after birth. The ductus arteriosis is a fetal artery connecting the aorta and the pulmonary artery. When the artery is not closed properly, it acts as a detour by not sending all the blood to the lungs (fetal blood obtains oxygen from the placenta). After birth, oxygen poor blood needs to go to the lungs to obtain oxygen. If the ductus arteriosis does not close, it can cause both the lungs and the heart to work too hard. PDA is sometimes found with other heart defects or in certain genetic conditions such as Down syndrome. PDA appears to be more common in girls.

Usually PDA is diagnosed in infancy but if it is small, symptoms may only appear in childhood. Severity of symptoms depends on the size and whether other heart defects are also present. Symptoms may include poor feeding or sweating while feeding, shortness of breath, tiring easily, fast pulse and poor growth. The causes of PDA are likely a combination of genetics and environment. Risk factors include premature birth, being born at a high altitude, a rubella infection during pregnancy, or a family history of certain genetic conditions.

A heart murmur is usually heard in infancy, but may be missed in a premature baby. The diagnosis will be confirmed using X-rays and an electrocardiogram (EKG). Other tests may check for other possible heart defects. In premature babies, the opening may close on its own even after the first few days, so the PDA may just be watched. Treatment options include medication and surgery, and may not be necessary. Outlook is excellent if PDA occurs without any associated birth defects. Talk to your baby’s cardiologist about treatment and management options. If the PDA is part of a syndrome or runs in your family, talk to a genetic counselor. Support groups are a good source of information and can connect you to other families affected by PDA.

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Condition Specific Organizations

Following organizations serve the condition "Patent ductus arteriosus" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Patent ductus arteriosus" returned 508 free, full-text research articles on human participants. First 3 results:

Effects of prophylactic oral ibuprofen on the closure rate of patent ductus arteriosus in premature infants.
 

Author(s): Yanjie Ding, Xuan Wang, Yanqiu Wu, Hui Li, Jiaju Xu, Xiaoliang Wang

Journal: Medicine (Baltimore). 2018 Sep;97(37):e12206.

 

The aim of this study was to investigate the effects of prophylactic oral ibuprofen on the closure rate of patent ductus arteriosus (PDA).This was a retrospective study and data on infants born before 36 weeks were collected. The prophylactic group was treated with ibuprofen (10, ...

Last Updated: 31 Dec 1969

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Transcatheter closure through single venous approach for young children with patent ductus arteriosus: A retrospective study of 686 cases.
 

Author(s): Jun Liu, Lei Gao, Hui-Lian Tan, Qing-Hou Zheng, Ling Liu, Zhen Wang

Journal: Medicine (Baltimore). 2018 Aug;97(35):e11958.

 

The objective is to explore the feasibility and safety of transcatheter closure of patent ductus arteriosus (PDA) through single venous approach in Chinese young children.A total of 1088 patients aged between 9 months old to 3 years old who underwent transcatheter closure of PDA from ...

Last Updated: 31 Dec 1969

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Patent ductus arteriosus coexisting with a left brachiocephalic artery originating from the descending aorta: A case report.
 

Author(s): Jiabing Huang, Xiaofan Peng, Xiangqian Shen, Xinqun Hu, Zhenfei Fang

Journal: Medicine (Baltimore). 2018 Aug;97(31):e11738.

 

Patent ductus arteriosus (PDA) and a coexisting left brachiocephalic artery originating from the descending aorta is an extremely rare anomaly of unknown etiology.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Patent ductus arteriosus" returned 37 free, full-text review articles on human participants. First 3 results:

Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis.
 

Author(s): Souvik Mitra, Ivan D Florez, Maria E Tamayo, Lawrence Mbuagbaw, Thuva Vanniyasingam, Areti Angeliki Veroniki, Adriana M Zea, Yuan Zhang, Behnam Sadeghirad, Lehana Thabane

Journal: JAMA. 2018 03;319(12):1221-1238.

 

Despite increasing emphasis on conservative management of patent ductus arteriosus (PDA) in preterm infants, different pharmacotherapeutic interventions are used to treat those developing a hemodynamically significant PDA.

Last Updated: 31 Dec 1969

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Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?
 

Author(s): Flaminia Bardanzellu, Paola Neroni, Angelica Dessì, Vassilios Fanos

Journal: Biomed Res Int. 2017 ;2017():1438038.

 

In preterm infants, failure or delay in spontaneous closure of Ductus Arteriosus (DA), resulting in the condition of Patent Ductus Arteriosus (PDA), represents a significant issue. A prolonged situation of PDA can be associated with several short- and long-term complications. Despite ...

Last Updated: 31 Dec 1969

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Percutaneous Patent Ductus Arteriosus (PDA) Closure During Infancy: A Meta-analysis.
 

Author(s): Carl H Backes, Brian K Rivera, Jeffrey A Bridge, Aimee K Armstrong, Brian A Boe, Darren P Berman, Tyler Fick, Ralf J Holzer, Ziyad M Hijazi, Sylvia Abadir, Henri Justino, Lisa Bergersen, Charles V Smith, Haresh Kirpalani

Journal: Pediatrics. 2017 Feb;139(2):.

 

Patent ductus arteriosus (PDA) is a precursor to morbidity and mortality. Percutaneous (catheter-based) closure is the procedure of choice for adults and older children with a PDA, but use during infancy (<1 year) is not well characterized.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Paracetamol And Ibuprofen in Closing Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 4 Sep 2018

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IV Acetaminophen and Patent Ductus Arteriosus
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 28 Jun 2017

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Near Infrared Spectroscopy to Determine Patent Ductus Arteriosus Closure
 

Status: Recruiting

Condition Summary: Patent Ductus Arteriosus

 

Last Updated: 26 Jun 2018

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