Pemphigus vulgaris

Common Name(s)

Pemphigus vulgaris

Pemphigus vulgaris is an autoimmune disorder that involves blistering of the skin and mucous membranes. It occurs almost exclusively in middle-aged or older people. Many cases begin with blisters in the mouth, followed by skin blisters that may come and go. In most cases, the exact cause of pemphigus vulgaris is unknown.  It has rarely been observed in multiple members of the same family. Treatment is aimed at reducing symptoms and preventing complications. Severe cases are treated similarly to severe burns.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus vulgaris" for support, advocacy or research.

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International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

Last Updated: 8 Mar 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus vulgaris" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

http://www.pemphigus.org/

Last Updated: 8 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pemphigus vulgaris" returned 288 free, full-text research articles on human participants. First 3 results:

Immunological markers as predictors of developing steroid-induced diabetes mellitus in pemphigus vulgaris patients: An observational study.
 

Author(s): Ana Sorina Dănescu, Ioana Bâldea, Daniel Corneliu Leucuţa, Iulia Lupan, Gabriel Samaşca, Cassian Sitaru, Roxana Chiorean, Adrian Baican

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0463.

 

The aim of this study was to evaluate the clinical importance of autoantibodies in pemphigus vulgaris patients who developed steroid-induced diabetes mellitus (SID) because of the glucocorticoid therapy of pemphigus.A total of 137 patients with pemphigus vulgaris were studied. Patients ...

Last Updated: 31 Dec 1969

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Association between human leukocyte antigen-DRB1 and human leukocyte antigen-DQB1 alleles and pemphigus vulgaris in Indian patients: A case-control study.
 

Author(s): Anuradha Priyadarshini, Renu George, Dolly Daniel, Santosh Varughese, Visalakshi Jayaseelan

Journal: Indian J Dermatol Venereol Leprol. ;84(3):280-284.

 

HLA-DRB1*04, -DRB1*08, -DRB1*14, -DQB1*03 and -DQB1*05 are reported to have significant association with pemphigus vulgaris; however, this is partially dependent on ethnicity. This study was done to determine the HLA-DR and -DQ types prevalent in Indian patients with pemphigus vulgaris.

Last Updated: 31 Dec 1969

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Assessment of the Prevalence and Risk Factors Associated With Glucocorticoid-Induced Diabetes Mellitus in Pemphigus Vulgaris Patients.
 

Author(s): Abbas Darjani, Nahid Nickhah, Mohammad Hassan Hedayati Emami, Narges Alizadeh, Rana Rafiei, Hojat Eftekhari, Kaveh Gharaei Nejad

Journal: Acta Med Iran. 2017 Jun;55(6):375-380.

 

Pemphigus vulgaris is a chronic autoimmune disease and glucocorticoids are one of the main treatments. Our study investigates the prevalence and associated factors of glucocorticoid-induced diabetes mellitus in these patients under different glucocorticoid regimens. 36 patients with ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pemphigus vulgaris" returned 18 free, full-text review articles on human participants. First 3 results:

A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris.
 

Author(s): Vincent Van Drongelen, Joseph Holoshitz

Journal:

 

Human leukocyte antigens (HLA) have been extensively studied as being antigen presenting receptors, but many aspects of their function remain elusive, especially their association with various autoimmune diseases. Here we discuss an illustrative case of the reciprocal relationship ...

Last Updated: 31 Dec 1969

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Management of Pemphigus Vulgaris.
 

Author(s): Mimansa Cholera, Nita Chainani-Wu

Journal: Adv Ther. 2016 06;33(6):910-58.

 

Pemphigus vulgaris (PV) is a chronic, autoimmune, vesiculobullous disease. As a result of the relative rarity of PV, published randomized controlled trials (RCTs) are limited, which makes it difficult to evaluate the efficacy of different treatment regimens in this disease. This also ...

Last Updated: 31 Dec 1969

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The dual nature of interleukin-10 in pemphigus vulgaris.
 

Author(s): Michael Jeffrey Cho, Christoph T Ellebrecht, Aimee S Payne

Journal: Cytokine. 2015 Jun;73(2):335-41.

 

The immunomodulatory cytokine interleukin-10 (IL-10) plays beneficial but also potentially detrimental roles in inflammation, infection, and autoimmunity. Recent studies suggest a regulatory role for IL-10-expressing B cells in the autoimmune blistering disease pemphigus vulgaris. ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Serum IL-21 Levels in Patients With Pemphigus Vulgaris
 

Status: Not yet recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 4 Jun 2017

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A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 29 Aug 2018

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A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 8 May 2018

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