Pemphigus

Common Name(s)

Pemphigus

Pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals).  This condition can occur at any age, but often strikes people in middle or older age. It is more common in people of Middle Eastern or Jewish descent than in other races and cultures. Pemphigus is a chronic disease which is best controlled by early diagnosis and treatment.  Treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections.

There are three main types of pemphigus:

Pemphigus vulgaris Pemphigus foliaceus  Paraneoplastic pemphigus
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

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International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

Last Updated: 8 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pemphigus" for support, advocacy or research.

Logo
International Pemphigus and Pemphigoid Foundation

The IPPF provides direct access to innovative and effective support that promotes the very best health care, improves quality of life, stimulates community resources, advocates for favorable government policies, accelerates the pace of scientific discovery and is the world’s best source of information on pemphigus and pemphigoid. We are compassionate in understanding, tireless in service, and relentless in advocating. One person at a time, we make a difference, building a community of care and hope.

http://www.pemphigus.org/

Last Updated: 8 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pemphigus" returned 711 free, full-text research articles on human participants. First 3 results:

Immunological markers as predictors of developing steroid-induced diabetes mellitus in pemphigus vulgaris patients: An observational study.
 

Author(s): Ana Sorina Dănescu, Ioana Bâldea, Daniel Corneliu Leucuţa, Iulia Lupan, Gabriel Samaşca, Cassian Sitaru, Roxana Chiorean, Adrian Baican

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0463.

 

The aim of this study was to evaluate the clinical importance of autoantibodies in pemphigus vulgaris patients who developed steroid-induced diabetes mellitus (SID) because of the glucocorticoid therapy of pemphigus.A total of 137 patients with pemphigus vulgaris were studied. Patients ...

Last Updated: 31 Dec 1969

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The importance of direct immunofluorescence in pemphigus herpetiformis diagnosis.
 

Author(s): Paula Carolina Pessanha de Faria, Camila Caberlon Cruz, Luna Azulay Abulafia, Juan Manuel Pineiro Maceira, Flávia de Freire Cassia, Paula Mota Medeiros

Journal: An Bras Dermatol. 2017 ;92(5 Suppl 1):145-147.

 

Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first ...

Last Updated: 31 Dec 1969

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Pemphigus foliaceus with pustular presentation in a patient with psoriasis.
 

Author(s): Vando Barbosa de Sousa, Cândida Naira Lima E Lima Santana, Daniele do Nascimento Pereira, Alexandre Carlos Gripp

Journal: An Bras Dermatol. 2017 ;92(5 Suppl 1):115-117.

 

Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pemphigus" returned 54 free, full-text review articles on human participants. First 3 results:

Pemphigus.
 

Author(s): Michael Kasperkiewicz, Christoph T Ellebrecht, Hayato Takahashi, Jun Yamagami, Detlef Zillikens, Aimee S Payne, Masayuki Amagai

Journal:

 

Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) causes blisters and erosions. Pemphigus has three major subtypes: pemphigus vulgaris, pemphigus foliaceus ...

Last Updated: 31 Dec 1969

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A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris.
 

Author(s): Vincent Van Drongelen, Joseph Holoshitz

Journal:

 

Human leukocyte antigens (HLA) have been extensively studied as being antigen presenting receptors, but many aspects of their function remain elusive, especially their association with various autoimmune diseases. Here we discuss an illustrative case of the reciprocal relationship ...

Last Updated: 31 Dec 1969

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Management of Pemphigus Vulgaris.
 

Author(s): Mimansa Cholera, Nita Chainani-Wu

Journal: Adv Ther. 2016 Jun;33(6):910-58.

 

Pemphigus vulgaris (PV) is a chronic, autoimmune, vesiculobullous disease. As a result of the relative rarity of PV, published randomized controlled trials (RCTs) are limited, which makes it difficult to evaluate the efficacy of different treatment regimens in this disease. This also ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Serum IL-21 Levels in Patients With Pemphigus Vulgaris
 

Status: Not yet recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 4 Jun 2017

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A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 8 May 2018

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A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris
 

Status: Recruiting

Condition Summary: Pemphigus Vulgaris

 

Last Updated: 5 Dec 2017

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