Peptic ulcer

Common Name(s)

Peptic ulcer

Peptic ulcer disease refers to a condition in which open sores or ulcers develop in the inside layer of the stomach, the upper portion of the small intestine (duodenum) or the esophagus (food pipe). Stress and diet are no longer believed to cause the ulcers. Between 80-90% of peptic ulcers are caused by the bacteria, Helicobacter pylori (H.pylori). Another contributing factor is the presence of high levels of certain stomach acids (pepsin and hydrochloric acid, both normally produced by our digestive system to help break down foods). Cigarette smoking, caffeine and certain genetic conditions may increase stomach acid levels. Peptic ulcers may also be caused by certain anti-inflammatory pain medications such as ibuprofen, aspirin and naproxen (Aleve). Symptoms of peptic ulcers include abdominal pain, bloating, nausea and vomiting, loss of appetite and weight, feeling tired, and dark or black stool (caused by bleeding). Peptic ulcers are diagnosed through special tests such as an upper GI or an endoscopy. H. pylori infection may be confirmed through a breath test, blood test or from a tissue sample gathered during an endoscopy. In many cases peptic ulcers will heal on their own or with over the counter medications, but they may return. Symptoms of peptic ulcers should not be ignored. Untreated ulcers may lead to more serious health problems which could be life threatening such as severe anemia (due to blood loss) or peritonitis (which occurs when the ulcer eats a hole through the stomach and allows digested food and stomach acids to enter the abdomen). Medications are available to help block the production of stomach acid and protect the stomach lining. Antibiotics can treat an H. pylori infection. Surgery may be required if medications do not work or due to certain complications. Talk with your doctor if you or your child has been diagnosed with peptic ulcer disease to decide on the best treatment plan.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Peptic ulcer" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Peptic ulcer" returned 874 free, full-text research articles on human participants. First 3 results:

Endovascular stent graft repair of aortogastric fistula caused by peptic ulcer after esophagectomy: A case report.
 

Author(s): Xiao-Qing Wei, Lei Song, Xue-Song Zhang, Kui-Yang Wang, Jie Wu

Journal: Medicine (Baltimore). 2017 Dec;96(50):e8959.

 

Aortogastric fistula (AGF) is a rare but devastating clinical complication after esophagectomy. In a recent report, nearly all AGF patients died of massive hemorrhage or aspiration of massive hematemesis. Therefore, timely appropriate treatment of AGF remains a challenge.Herein, we ...

Last Updated: 31 Dec 1969

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Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population.
 

Author(s): Jihye Kim, Keun Ho Kim, Bum Ju Lee

Journal:

 

Peptic ulcer disease (PUD) is a common disorder, but whether an association exists between PUD and anthropometric indicators remains controversial. Furthermore, no studies on the association of PUD with anthropometric indices, blood parameters, and nutritional components have been ...

Last Updated: 31 Dec 1969

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The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article.
 

Author(s): Young Bok Lee, Jihan Yu, Hyun Ho Choi, Bu Seok Jeon, Hyung-Keun Kim, Sang-Woo Kim, Sung Soo Kim, Yong Gyu Park, Hiun Suk Chae

Journal: Medicine (Baltimore). 2017 Aug;96(34):e7828.

 

This study aimed to investigate the association between the prevalence of peptic ulcer disease (PUD) and mental health problems, such as severe stress, depressive mood, and suicidal ideation.The population-based cross-sectional study was comprised of 14,266 subjects participating ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Peptic ulcer" returned 67 free, full-text review articles on human participants. First 3 results:

Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks: A meta-analysis.
 

Author(s): Qiuping Li, Jingwei Liu, Yuehua Gong, Yuan Yuan

Journal: Medicine (Baltimore). 2017 Apr;96(17):e6620.

 

Increasingly, studies have focused on the relationship between Helicobacter pylori (H pylori) cytotoxin associated gene A protein (CagA) Glu-Pro-Ile-Tyr-Ala (EPIYA)-D motifs or multiple EPIYA-C phosphorylation sites and peptic ulcer disease (PUD) or gastric cancer (GC) risk. However, ...

Last Updated: 31 Dec 1969

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Validity of peptic ulcer disease and upper gastrointestinal bleeding diagnoses in administrative databases: a systematic review protocol.
 

Author(s): Alessandro Montedori, Iosief Abraha, Carlos Chiatti, Francesco Cozzolino, Massimiliano Orso, Maria Laura Luchetta, Joseph M Rimland, Giuseppe Ambrosio

Journal:

 

Administrative healthcare databases are useful to investigate the epidemiology, health outcomes, quality indicators and healthcare utilisation concerning peptic ulcers and gastrointestinal bleeding, but the databases need to be validated in order to be a reliable source for research. ...

Last Updated: 31 Dec 1969

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Diabetes increases morbidity and mortality rates in peptic ulcer bleeding: An updated systematic review and meta-analysis.
 

Author(s): Fengqin Wei, Xiaoti Lin

Journal: Turk J Gastroenterol. 2016 Jul;27(4):304-11.

 

To elucidate the relationship between diabetes mellitus (DM) and the risk of peptic ulcer complications.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers
 

Status: Recruiting

Condition Summary: Non-Bleeding Peptic Ulcers

 

Last Updated: 24 Nov 2017

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Last Updated: 23 Oct 2017

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Last Updated: 28 Sep 2017

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