Peptic ulcer

Common Name(s)

Peptic ulcer

Peptic ulcer disease refers to a condition in which open sores or ulcers develop in the inside layer of the stomach, the upper portion of the small intestine (duodenum) or the esophagus (food pipe). Stress and diet are no longer believed to cause the ulcers. Between 80-90% of peptic ulcers are caused by the bacteria, Helicobacter pylori (H.pylori). Another contributing factor is the presence of high levels of certain stomach acids (pepsin and hydrochloric acid, both normally produced by our digestive system to help break down foods). Cigarette smoking, caffeine and certain genetic conditions may increase stomach acid levels. Peptic ulcers may also be caused by certain anti-inflammatory pain medications such as ibuprofen, aspirin and naproxen (Aleve). Symptoms of peptic ulcers include abdominal pain, bloating, nausea and vomiting, loss of appetite and weight, feeling tired, and dark or black stool (caused by bleeding). Peptic ulcers are diagnosed through special tests such as an upper GI or an endoscopy. H. pylori infection may be confirmed through a breath test, blood test or from a tissue sample gathered during an endoscopy. In many cases peptic ulcers will heal on their own or with over the counter medications, but they may return. Symptoms of peptic ulcers should not be ignored. Untreated ulcers may lead to more serious health problems which could be life threatening such as severe anemia (due to blood loss) or peritonitis (which occurs when the ulcer eats a hole through the stomach and allows digested food and stomach acids to enter the abdomen). Medications are available to help block the production of stomach acid and protect the stomach lining. Antibiotics can treat an H. pylori infection. Surgery may be required if medications do not work or due to certain complications. Talk with your doctor if you or your child has been diagnosed with peptic ulcer disease to decide on the best treatment plan.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Peptic ulcer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Peptic ulcer" returned 904 free, full-text research articles on human participants. First 3 results:

Choledochoduodenal fistula due to peptic duodenal ulcer diagnosed by X-barium meal study: interest of medical treatment.
 

Author(s): Mohamed Ali Chaouch, Karim Nacef, Mossab Ghannouchi, Mohamed Ben Khalifa, Asma Chaouch, Molk Abdelkafi, Saida Jerbi, Moez Boudokhane

Journal:

 

Peptic ulcer complication has decreased over le last years. Spontaneous bilio-digestive fistulas, in the absence of primary biliary disease, remain a very unusual complication of the upper digestive tract. The choledochoduodenal fistula is an extremely rare entity which can be caused ...

Last Updated: 31 Dec 1969

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Association between emergency admission for peptic ulcer bleeding and air pollution: a case-crossover analysis in Hong Kong's elderly population.
 

Author(s): Linwei Tian, Hong Qiu, Shengzhi Sun, Hilda Tsang, King-Pan Chan, Wai K Leung

Journal: Lancet Planet Health. 2017 05;1(2):e74-e81.

 

Air pollution increases intestinal permeability, alters the gut microbiome, and promotes inflammation, which might contribute towards gastrointestinal bleeding. In the present study, we aim to examine whether short-term elevations in air pollution are associated with increased numbers ...

Last Updated: 31 Dec 1969

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Does breathing polluted air increase the risk of upper gastrointestinal bleeding from peptic ulcer disease?
 

Author(s): Gilaad G Kaplan

Journal: Lancet Planet Health. 2017 05;1(2):e54-e55.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Peptic ulcer" returned 71 free, full-text review articles on human participants. First 3 results:

Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks: A meta-analysis.
 

Author(s): Qiuping Li, Jingwei Liu, Yuehua Gong, Yuan Yuan

Journal: Medicine (Baltimore). 2017 Apr;96(17):e6620.

 

Increasingly, studies have focused on the relationship between Helicobacter pylori (H pylori) cytotoxin associated gene A protein (CagA) Glu-Pro-Ile-Tyr-Ala (EPIYA)-D motifs or multiple EPIYA-C phosphorylation sites and peptic ulcer disease (PUD) or gastric cancer (GC) risk. However, ...

Last Updated: 31 Dec 1969

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Validity of peptic ulcer disease and upper gastrointestinal bleeding diagnoses in administrative databases: a systematic review protocol.
 

Author(s): Alessandro Montedori, Iosief Abraha, Carlos Chiatti, Francesco Cozzolino, Massimiliano Orso, Maria Laura Luchetta, Joseph M Rimland, Giuseppe Ambrosio

Journal:

 

Administrative healthcare databases are useful to investigate the epidemiology, health outcomes, quality indicators and healthcare utilisation concerning peptic ulcers and gastrointestinal bleeding, but the databases need to be validated in order to be a reliable source for research. ...

Last Updated: 31 Dec 1969

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Laparoscopic versus open repair for perforated peptic ulcer: A meta analysis of randomized controlled trials.
 

Author(s): Shanjun Tan, Guohao Wu, Qiulin Zhuang, Qiulei Xi, Qingyang Meng, Yi Jiang, Yusong Han, Chao Yu, Zhen Yu, Ning Li

Journal: Int J Surg. 2016 Sep;33 Pt A():124-32.

 

The role of laparoscopic surgery in the repair for peptic ulcer disease is unclear. The present study aimed to compare the safety and efficacy of laparoscopic versus open repair for peptic ulcer disease.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers
 

Status: Recruiting

Condition Summary: Non-Bleeding Peptic Ulcers

 

Last Updated: 24 Jul 2018

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Last Updated: 23 Oct 2017

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Last Updated: 28 Sep 2017

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