Periodic Paralysis

Common Name(s)

Periodic Paralysis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periodic Paralysis" for support, advocacy or research.

Periodic Paralysis Association

To provide convenient access to science-based information to help better understand and manage the periodic paralyses. To stimulate interaction between the periodic paralysis community and various professional disciplines that may be able to bring light to this complex and often misunderstood collection of disorders. To provide the tools and a forum for open discussion of the diverse issues associated with these disorders. To promote an increasing level of awareness of these disorders, leading to increased research, improved management guidelines, improved diagnostic protocols, and ultimately, their prevention and cure

Last Updated: 23 Jun 2015

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

Last Updated: 12 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Periodic Paralysis" for support, advocacy or research.

Periodic Paralysis Association

To provide convenient access to science-based information to help better understand and manage the periodic paralyses. To stimulate interaction between the periodic paralysis community and various professional disciplines that may be able to bring light to this complex and often misunderstood collection of disorders. To provide the tools and a forum for open discussion of the diverse issues associated with these disorders. To promote an increasing level of awareness of these disorders, leading to increased research, improved management guidelines, improved diagnostic protocols, and ultimately, their prevention and cure

http://www.periodicparalysis.org

Last Updated: 23 Jun 2015

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

http://hkpp.org

Last Updated: 12 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Periodic Paralysis" returned 184 free, full-text research articles on human participants. First 3 results:

Spider toxin inhibits gating pore currents underlying periodic paralysis.
 

Author(s): Roope Männikkö, Zakhar O Shenkarev, Michael G Thor, Antonina A Berkut, Mikhail Yu Myshkin, Alexander S Paramonov, Dmitrii S Kulbatskii, Dmitry A Kuzmin, Marisol Sampedro Castañeda, Louise King, Emma R Wilson, Ekaterina N Lyukmanova, Mikhail P Kirpichnikov, Stephanie Schorge, Frank Bosmans, Michael G Hanna, Dimitri M Kullmann, Alexander A Vassilevski

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2018 04;115(17):4495-4500.

 

Gating pore currents through the voltage-sensing domains (VSDs) of the skeletal muscle voltage-gated sodium channel Na1.4 underlie hypokalemic periodic paralysis (HypoPP) type 2. Gating modifier toxins target ion channels by modifying the function of the VSDs. We tested the hypothesis ...

Last Updated: 31 Dec 1969

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Na leak with gating pore properties in hypokalemic periodic paralysis V876E mutant muscle Ca channel.
 

Author(s): Clarisse Fuster, Jimmy Perrot, Christine Berthier, Vincent Jacquemond, Pierre Charnet, Bruno Allard

Journal: J. Gen. Physiol.. 2017 Dec;149(12):1139-1148.

 

Type 1 hypokalemic periodic paralysis (HypoPP1) is a poorly understood genetic neuromuscular disease characterized by episodic attacks of paralysis associated with low blood K The vast majority of HypoPP1 mutations involve the replacement of an arginine by a neutral residue in one ...

Last Updated: 31 Dec 1969

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Successful treatment of periodic paralysis with coenzyme Q10: two case reports.
 

Author(s): Yuwei Da, Lin Lei, Karin Jurkat-Rott, Frank Lehmann-Horn

Journal: Acta Myol. 2016 Oct;35(2):107-108.

 

Primary periodic paralyses (PPs) are autosomal dominant ion channel disorders characterized by episodic flaccid weakness associated with variations in serum potassium level. The main prophylactic therapy of choice for PPsis carbonic anhydrase inhibitors that are not always effective. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Periodic Paralysis" returned 10 free, full-text review articles on human participants. First 3 results:

Thyrotoxic periodic paralysis: an unusual presentation of hyperthyroidism.
 

Author(s): M Salih, C M J van Kinschot, R P Peeters, W W de Herder, E J J Duschek, J van der Linden, C van Noord

Journal: Neth J Med. 2017 Oct;75(8):315-320.

 

Thyrotoxic periodic paralysis (TPP) is a complication of hyperthyroidism among Asians, characterised by sudden onset of hypokalaemia and muscle paralysis. Several factors may contribute to a delay in diagnosis, including the subtlety of hyperthyroidism, the transient nature of the ...

Last Updated: 31 Dec 1969

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Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis.
 

Author(s): Chih-Jen Cheng, Elizabeth Kuo, Chou-Long Huang

Journal: Semin. Nephrol.. 2013 May;33(3):237-47.

 

Extracellular potassium makes up only about 2% of the total body's potassium store. The majority of the body potassium is distributed in the intracellular space, of which about 80% is in skeletal muscle. Movement of potassium in and out of skeletal muscle thus plays a pivotal role ...

Last Updated: 31 Dec 1969

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Mechanism of thyrotoxic periodic paralysis.
 

Author(s): Shih-Hua Lin, Chou-Long Huang

Journal: J. Am. Soc. Nephrol.. 2012 Jun;23(6):985-8.

 

The pathogenesis of thyrotoxic periodic paralysis has long been thought related to increased Na(+)-K(+) ATPase activity stimulated by thyroid hormone and/or hyperadrenergic activity and hyperinsulinemia. This mechanism alone, however, cannot adequately explain how hypokalemia occurs ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 3 Apr 2018

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