Peripheral artery disease

Common Name(s)

Peripheral artery disease

Peripheral artery disease (PAD) is a condition where the legs and/or arms do not receive enough blood. This condition develops most commonly in the legs and is usually caused by a buildup of fatty deposits in the arteries leading to the legs. Eventually, these deposits may result in narrowing of the arteries (atherosclerosis) putting the affected individual at risk for a heart attack or stroke. Other less common causes of PAD include inflammation (including swelling) of the arteries, certain leg injuries, certain problems with ligaments or muscles in the legs, and radiation exposure.

Individuals with PAD often feel pain while walking (intermittent claudication). Other symptoms include leg cramping, leg numbness or weakness, one leg feeling colder than the other, sores that don’t heal quickly, hair loss on legs, slow growing toenails, and skin that can be shiny or a different color.

The largest risk factor is smoking. Diabetes, obesity, high blood pressure, high cholesterol, aging, a family history, and high levels of a protein called homocysteine also increase your risk for developing PAD.

A diagnosis can be made in several ways. Your doctor may conduct a physical exam, perform an ultrasound, look at your blood vessels by injecting dye into them (angiography), or run blood tests. An ankle-brachial index (ABI) test may also be used to compare the blood pressure levels in your arms and legs. Some people with PAD can be treated with simple lifestyle changes, such as quitting smoking, exercising regularly, and eating healthy. In more severe cases, your doctor may prescribe certain medications or recommend surgery to stop the atherosclerosis from getting worse. Research is ongoing, so if you have been diagnosed with PAD, talk with your doctor and specialists about the most current treatment options. Support groups are good sources of information and can help connect you with others living with PAD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Peripheral artery disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Peripheral artery disease" returned 482 free, full-text research articles on human participants. First 3 results:

Effect of Granulocyte-Macrophage Colony-Stimulating Factor With or Without Supervised Exercise on Walking Performance in Patients With Peripheral Artery Disease: The PROPEL Randomized Clinical Trial.
 

Author(s): Mary M McDermott, Luigi Ferrucci, Lu Tian, Jack M Guralnik, Donald Lloyd-Jones, Melina R Kibbe, Tamar S Polonsky, Kathryn Domanchuk, James H Stein, Lihui Zhao, Doris Taylor, Christopher Skelly, William Pearce, Harris Perlman, Walter McCarthy, Lingyu Li, Ying Gao, Robert Sufit, Christina L Bloomfield, Michael H Criqui

Journal: JAMA. 2017 12;318(21):2089-2098.

 

Benefits of granulocyte-macrophage colony-stimulating factor (GM-CSF) for improving walking ability in people with lower extremity peripheral artery disease (PAD) are unclear. Walking exercise may augment the effects of GM-CSF in PAD, since exercise-induced ischemia enhances progenitor ...

Last Updated: 31 Dec 1969

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Prevalence of peripheral artery disease (PAD) and factors associated: An epidemiological analysis from the population-based Screening PRE-diabetes and type 2 DIAbetes (SPREDIA-2) study.
 

Author(s): V Cornejo Del Río, J Mostaza, C Lahoz, V Sánchez-Arroyo, C Sabín, S López, P Patrón, P Fernández-García, B Fernández-Puntero, D Vicent, L Montesano-Sánchez, F García-Iglesias, T González-Alegre, E Estirado, F Laguna, C de Burgos-Lunar, P Gómez-Campelo, J C Abanades-Herranz, J M de Miguel-Yanes, M A Salinero-Fort,

Journal:

 

To describe the prevalence of Peripheral Artery Disease (PAD) in a random population sample and to evaluate its relationship with Mediterranean diet and with other potential cardiovascular risk factors such as serum uric acid and pulse pressure in individuals ranged 45 to 74 years.

Last Updated: 31 Dec 1969

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Socioeconomic Status and Incidence of Hospitalization With Lower-Extremity Peripheral Artery Disease: Atherosclerosis Risk in Communities Study.
 

Author(s): Priya Vart, Josef Coresh, Lucia Kwak, Shoshana H Ballew, Gerardo Heiss, Kunihiro Matsushita

Journal:

 

Compared to coronary heart disease, heart failure, and stroke, the relationship between low socioeconomic status (SES) and peripheral artery disease (PAD) is less well established. We examined the association between SES and incidence of hospitalization with PAD and explored whether ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Peripheral artery disease" returned 71 free, full-text review articles on human participants. First 3 results:

Surrogate and clinical endpoints for studies in peripheral artery occlusive disease: Are statistics the brakes?
 

Author(s): Matthias W Waliszewski, Ulf Redlich, Victor Breul, Jörg Tautenhahn

Journal: Pol Przegl Chir. 2017 Apr;89(2):39-48.

 

The aim of this review is to present the available clinical and surrogate endpoints that may be used in future studies performed in patients with peripheral artery occlusive disease (PAOD). Importantly, we describe statistical limitations of the most commonly used endpoints and offer ...

Last Updated: 31 Dec 1969

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Peripheral artery disease, redox signaling, oxidative stress - Basic and clinical aspects.
 

Author(s): Sebastian Steven, Andreas Daiber, Jörn F Dopheide, Thomas Münzel, Christine Espinola-Klein

Journal: Redox Biol. 2017 08;12():787-797.

 

Reactive oxygen and nitrogen species (ROS and RNS, e.g. HO, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. At higher concentrations, ROS and RNS lead to oxidative stress and oxidative ...

Last Updated: 31 Dec 1969

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Atherectomy in Peripheral Artery Disease: A Review.
 

Author(s): Tariq M Bhat, Maxwell E Afari, Lawrence A Garcia

Journal: J Invasive Cardiol. 2017 Apr;29(4):135-144.

 

Peripheral arterial disease (PAD) is a clinical manifestation of systemic atherosclerosis and is associated with significant morbidity and mortality. The physiological force and shear stress from angioplasty and stenting have made PAD treatment challenging. Atherectomy devices have ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

SHOWME-PAD (Peripheral Artery Disease)
 

Status: Not yet recruiting

Condition Summary: Peripheral Artery Disease

 

Last Updated: 14 Jun 2017

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Daily Step-based Exercise Using Fitness Monitors for Peripheral Artery Disease
 

Status: Recruiting

Condition Summary: Peripheral Artery Disease

 

Last Updated: 14 Nov 2017

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