Plasminogen activator inhibitor type 1 deficiency

Common Name(s)

Plasminogen activator inhibitor type 1 deficiency

Plasminogen activator inhibitor type 1 (PAI-1) deficiency a rare disorder that causes premature breakdown of blood clots and a moderate bleeding syndrome. While spontaneous bleeding is rare, moderate hemorrhages of the knees, elbows, nose and gums may be triggered by mild trauma. In females, menstrual bleeding is often severe. Prolonged bleeding after surgery is also common.   PAI-1 deficiency is caused by homozygous or compound heterozygous mutation in the SERPINE1 gene.   Fibrinolysis inhibitors, including epsilon-aminocaproic acid and tranexamic acid, are usually effective in treating and preventing bleeding episodes.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Plasminogen activator inhibitor type 1 deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Plasminogen activator inhibitor type 1 deficiency" returned 3 free, full-text research articles on human participants. First 3 results:

Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumonia.
 

Author(s): Anita W Rijneveld, Sandrine Florquin, Paul Bresser, Marcel Levi, Vivian De Waard, Roger Lijnen, Jaring S Van Der Zee, Peter Speelman, Peter Carmeliet, Tom Van Der Poll

Journal: Blood. 2003 Aug;102(3):934-9.

 

Urokinase-type plasminogen activator (uPA) and its receptor uPAR are components of the fibrinolytic system and are important for an adequate immune response to respiratory tract infection, in part through their role in the migration of inflammatory cells. PA inhibitor-1 (PAI-1) is ...

Last Updated: 18 Jul 2003

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Brief report: complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation.
 

Author(s): W P Fay, A D Shapiro, J L Shih, R R Schleef, D Ginsburg

Journal: N. Engl. J. Med.. 1992 Dec;327(24):1729-33.

 

Last Updated: 17 Dec 1992

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A lifelong bleeding disorder associated with a deficiency of plasminogen activator inhibitor type 1.
 

Author(s): J DiƩval, G Nguyen, S Gross, J Delobel, E K Kruithof

Journal: Blood. 1991 Feb;77(3):528-32.

 

A 36-year-old patient was investigated for a lifelong history of epistaxis and delayed bleeding after minor surgeries. Deficiencies or abnormalities of the coagulation system, of platelet function, or of factor XIII and alpha-2-antiplasmin were excluded. Consistently, however, over ...

Last Updated: 8 Mar 1991

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Reviews from the PubMed Database

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The terms "Plasminogen activator inhibitor type 1 deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.