Platelet-activating factor acetylhydrolase deficiency

Common Name(s)

Platelet-activating factor acetylhydrolase deficiency

Deficiency of plasma platelet-activating factor acetylhydrolase results in increased levels of PAF, a chemotactic lipid that activates inflammatory cells, bronchoconstriction, and airway hyperresponsiveness, and can moderate the release of inflammatory agonists. Asthmatic individuals with PAF acetylhydrolase deficiency may have exacerbated symptoms (summary by {5:Stafforini et al., 1999}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Platelet-activating factor acetylhydrolase deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Platelet-activating factor acetylhydrolase deficiency" returned 5 free, full-text research articles on human participants. First 3 results:

Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japan.
 

Author(s): N Unno, T Nakamura, H Kaneko, T Uchiyama, N Yamamoto, J Sugatani, M Miwa, S Nakamura

Journal: J. Vasc. Surg.. 2000 Aug;32(2):263-7.

 

Plasma platelet-activating factor acetylhydrolase (PAF-AH) is known to catalyze platelet-activating factor, thereby inactivating its inflammatory function. Deficiency of this enzyme is caused by a missense (G(994)-->T) in exon 9 of the plasma PAF-AH gene. In this study, we investigated ...

Last Updated: 19 Sep 2000

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Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma.
 

Author(s): D M Stafforini, T Numao, A Tsodikov, D Vaitkus, T Fukuda, N Watanabe, N Fueki, T M McIntyre, G A Zimmerman, S Makino, S M Prescott

Journal: J. Clin. Invest.. 1999 Apr;103(7):989-97.

 

Asthma, a family of airway disorders characterized by airway inflammation, has an increasing incidence worldwide. Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma. Its proinflammatory actions are antagonized by PAF acetylhydrolase. A missense mutation ...

Last Updated: 29 Apr 1999

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Deficiency of plasma platelet-activating factor acetylhydrolase: roles of blood cells.
 

Author(s): H Yoshida, K Satoh, M Koyama, M Hiramoto, S Takamatsu

Journal: Am. J. Hematol.. 1996 Nov;53(3):158-64.

 

Platelet-activating factor (PAF), a potent mediator of inflammation and circulatory shock, is inactivated by the enzyme PAF acetylhydrolase. Plasma PAF acetylhydrolase deficiency occurs even in healthy subjects. We hypothesized that erythrocyte PAF acetylhydrolase could play a supplementary ...

Last Updated: 23 Dec 1996

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Reviews from the PubMed Database

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The terms "Platelet-activating factor acetylhydrolase deficiency" returned 0 free, full-text review articles on human participants.

 
 
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