Polyarteritis nodosa

Common Name(s)

Polyarteritis nodosa, PAN

Polyarteritis nodosa (PAN) is a rare disease that causes redness and swelling (inflammation) of the medium sized tubes that carry blood around the body (blood vessels). This inflammation causes poor blood flow and leads to damage of affected organs. PAN most commonly affects the arteries in the skin, nerves, gut (intestinal tract), and kidneys. If only the skin is affected, it is called cutaneous PAN. If only one organ is affected, it is called localized PAN. Symptoms of PAN depend on the organ system involved. Symptoms may include general tiredness (fatigue), fever, loss of appetite, weight loss, pain in muscles or joints, skin sores, abdominal pain, blood in the stool, shortness of breath, chest pain, high blood pressure, and numbness. PAN can sometimes cause an increase in the size of part of a blood vessel (aneurysm), which can cause the vessel to break open (rupture).

The exact cause of PAN is unknown. Researchers believe it can be triggered by a reaction to a medication or a reaction to an infection (either bacterial or viral). These reactions are usually due to an issue with the body’s immune system. Men usually have PAN more often than women and people typically develop the condition between the ages of 40 and 60. Your doctor will use a combination of your symptoms, physical exam, blood tests and imaging tests (x-rays, MRIs and CTs) to diagnose PAN. In some cases, removal and examination of an affected area (biopsy) may be needed to confirm the diagnosis. Treatment of PAN varies, depending on the underlying cause and affected area. If you have been diagnosed with PAN, speak with your doctor to discuss the most current treatment options. Support groups are also a good source of additional information.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polyarteritis nodosa" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polyarteritis nodosa" returned 221 free, full-text research articles on human participants. First 3 results:

Chronic polyarthritis as the first manifestation of childhood systemic polyarteritis nodosa.
 

Author(s): Glaucia Vanessa Novak, Koken Hayashi, Kohei Sampa, Yosuke Okumura, Gabriela Ribeiro Viola Ferreira, Clovis Artur Silva

Journal: Einstein (Sao Paulo). ;15(1):96-99.

 

Arthritis has been reported as an acute pattern, generally evanescent with oligoarthritis, mostly affecting knees and ankles in childhood systemic polyarteritis nodosa. However, chronic polyarthritis with morning stiffness mimicking juvenile idiopathic arthritis has not been reported. ...

Last Updated: 26 Apr 2017

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Microscopic polyangiitis and non-HBV polyarteritis nodosa with poor-prognosis factors: 10-year results of the prospective CHUSPAN trial.
 

Author(s): Maxime Samson, Xavier Puéchal, Luc Mouthon, Hervé Devilliers, Pascal Cohen, Boris Bienvenu, Kim Heang Ly, Alain Bruet, Brigitte Gilson, Marc Ruivard, Edouard Pertuiset, Mohamed Hamidou, Christian Pagnoux, Benjamin Terrier, Loïc Guillevin,

Journal: Clin. Exp. Rheumatol.. ;35 Suppl 103(1):176-184.

 

To analyse the 10-year outcomes of 64 patients with non-HBV polyarteritis nodosa (PAN) or microscopic polyangiitis (MPA) and Five-Factor Score-defined poor-prognosis factors enrolled (1994-2000) in the prospective, randomised, open-label CHUSPAN trial.

Last Updated: 19 Apr 2017

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Necrotizing Polyarteritis Nodosa-like Vasculitis in a Child with Systemic Lupus Erythematosus.
 

Author(s): Ritambhra Nada, Joseph L Matthews, Sagar Bhattad, Anju Gupta, Surjit Singh

Journal: Indian Pediatr. 2017 Feb;54(2):139-144.

 

A 10-year-old child presented with prolonged fever, lymphadenopathy, weight loss, oral ulcers, alopecia and parotitis. She later developed arterial thrombosis, poly-serositis, nephritis, myocarditis, sacro-ilitis, autoimmune hemolytic anemia and refractory thrombocytopenia. Though ...

Last Updated: 12 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polyarteritis nodosa" returned 15 free, full-text review articles on human participants. First 3 results:

Polyarteritis nodosa.
 

Author(s): Travis Howard, Kinza Ahmad, Jerome Allen A Swanson, Sanjay Misra

Journal: Tech Vasc Interv Radiol. 2014 Dec;17(4):247-51.

 

The first description of polyarteritis nodosa (PAN) was in 1852 by Karl Rokitansky, a pathologist at the University of Vienna. The initial report describes a 23-year-old man who had a 5-day history of fever and diarrhea. Since then, the definition of PAN has evolved. The currently ...

Last Updated: 16 Mar 2015

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Pancreatic mass as an initial manifestation of polyarteritis nodosa: a case report and review of the literature.
 

Author(s): Yoshihiro Yokoi, Ippei Nakamura, Takeshi Kaneko, Tomoki Sawayanagi, Youichi Watahiki, Makoto Kuroda

Journal: World J. Gastroenterol.. 2015 Jan;21(3):1014-9.

 

Classic polyarteritis nodosa (PAN) that targets medium-sized muscular arteries and microscopic polyangiitis (MPA), characterized by inflammation of small-caliber vessels and the presence of circulating myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA), are distinct ...

Last Updated: 27 Jan 2015

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Cutaneous polyarteritis nodosa successfully treated with topical diflucortolone valerate: a case report & review of the literature.
 

Author(s): Ruby Haviv, Maya Capua, Jacob Amir, Liora Harel

Journal:

 

Cutaneous Polyarteritis Nodosa (cPAN) was first described in 1931. cPAN is considered a rare disease, its true incidence is unknown. The age of onset is diverse. Most studies have shown no significant gender predominance. cPAN presents with distinct skin findings, such as a maculopapular ...

Last Updated: 20 Oct 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Determining Disease Activity Biomarkers in Individuals With Polyarteritis Nodosa
 

Status: Recruiting

Condition Summary: Polyarteritis Nodosa

 

Last Updated: 1 May 2017

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A Randomized Multicenter Study for Isolated Skin Vasculitis
 

Status: Recruiting

Condition Summary: Primary Cutaneous Vasculitis; Cutaneous Polyarteritis Nodosa; IgA Vasculitis; Henoch-Schönlein Purpura

 

Last Updated: 19 Jun 2017

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Pediatric Vasculitis Initiative
 

Status: Recruiting

Condition Summary: Wegeners Granulomatosis (Granulomatosis With Polyangiitis); Microscopic Polyangiitis; Churg Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis); Polyarteritis Nodosa; Takayasu Arteritis; Primary CNS Vasculitis; Unclassified Vasculitis

 

Last Updated: 1 May 2017

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