Polydactyly

Common Name(s)

Polydactyly, Hyperdactyly

Polydactyly is extra digits (fingers or toes) that are present at birth (congenital). A baby born with polydactyly will have more than 5 digits on one or both of their hands or feet. Polydactyly can occur without any other complications (isolated polydactyly) or it can be seen in a baby who has many abnormal features as part of a syndrome (syndromic polydactyly). Typically, the extra digit is a small piece of soft tissue that can be easily removed with surgery. Sometimes, the extra digit will contain bones or even be an entire functioning digit. There are three main forms of polydactyly. The most common form has the extra digit located on the side with the small digit (ulnar or postaxial polydactyly). Another form has the extra digit located on the side with the large digit - the thumb or big toe (radial or preaxial polydactyly). The third form, which is rare, causes an extra middle digit (central polydactyly)

Isolated polydactyly is an autosomal dominant genetic condition. This means that a mutation (change) in one of the two copies of a gene causes polydactyly. Mutations in many different genes can cause isolated polydactyly. There are also at least 39 different syndromes that have polydactyly as one of their features. Isolated polydactyly occurs much more often in African American people. Polydactyly can be easily diagnosed with a physical exam performed by your baby’s doctor. If your baby has other features in addition to polydactyly that may suggest a syndrome, or if you have a strong family history of isolated polydactyly (many affected family members), an evaluation by a geneticist and genetic counselor can be beneficial. Treatment of polydactyly usually involves surgical removal of the extra digit. However, the type of surgery your baby may need varies greatly and depends on both the location and type of polydactyly. If your baby has polydactyly, talk with your doctor to discuss the best treatment plan.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polydactyly" for support, advocacy or research.

Bardet Biedl Syndrome Family Association

Our Mission: Improve the lives of families affected by BBS through information, support and by advancing research and therapy Our Vision: Effective support, therapy, and treatment for all people affected by Bardet Biedl Syndrome

Last Updated: 14 Mar 2013

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National Foundation for Syndactyly

The National Foundation for Syndactyly Research, Support, and Education is a charitable, tax-exempt, 501(c)(3) organization organized to fund research, support, and education. The foundation serves as a resource to connect families touched by Syndactyly and other related hand abnormalities with other families, facilities for treatment, and board certified hand physicians who specialize in Syndactyly treatment. We provide research grants to investigate the causes and best practices in treatment as funding permits. - See more at: http://nfsus.org

Last Updated: 8 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Polydactyly" for support, advocacy or research.

Bardet Biedl Syndrome Family Association

Our Mission: Improve the lives of families affected by BBS through information, support and by advancing research and therapy Our Vision: Effective support, therapy, and treatment for all people affected by Bardet Biedl Syndrome

http://www.bardetbiedl.org/

Last Updated: 14 Mar 2013

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National Foundation for Syndactyly

The National Foundation for Syndactyly Research, Support, and Education is a charitable, tax-exempt, 501(c)(3) organization organized to fund research, support, and education. The foundation serves as a resource to connect families touched by Syndactyly and other related hand abnormalities with other families, facilities for treatment, and board certified hand physicians who specialize in Syndactyly treatment. We provide research grants to investigate the causes and best practices in treatment as funding permits. - See more at: http://nfsus.org

http://nfsus.org

Last Updated: 8 Jul 2015

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General Support Organizations

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General Resources

Facility and Physician Support

NFS provides informational brochures to Children's' Hospitals, Physicians, and Therapy Centers to help afflicted families connect to NFS Family Support Services.

Updated 7 Jul 2015

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Family Support

NFS serves as a resource to families afflicted by Syndactyly or any related congenial hand or feet birth defects.

Updated 7 Jul 2015

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Research Grants

NFS provides research grants as funds are available. Grants are submitted by July annually and if approved, are awarded each September. Grant are only available for qualified research initiatives and are not available for administrative support.

Updated 7 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Polydactyly" returned 112 free, full-text research articles on human participants. First 3 results:

Identity-by-descent refines mapping of candidate regions for preaxial polydactyly II /III in a large Chinese pedigree.
 

Author(s): Xingyan Yang, Quankuan Shen, Xierzhatijiang Sulaiman, Hequn Liu, Minsheng Peng, Yaping Zhang

Journal:

 

Preaxial polydactyly (PPD) is congenital hand malformation characterized by the duplication of digit. Herein, we scan the genome-wide SNPs for a large Chinese family with PPD-II/III. We employ the refined IBD algorithm to identify the identity-by-decent (IBD) segments and compare ...

Last Updated: 10 Jul 2017

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Polydactyly and obesity - the clinical manifestation of ciliopathy: a boy with Bardet-Biedl syndrome.
 

Author(s): Agnieszka Szmigielska, Grażyna Krzemień, Maria Roszkowska-Blaim, Ewa Obersztyn

Journal: Dev Period Med. ;20(2):105-9.

 

The prevalence of obesity in children is still rising all over the world. The most common reason for significant weight gain is a high-calorie diet and decreased physical activity. However, apart from environmental factors, genetic predisposition plays a crucial role in the pathomechanism ...

Last Updated: 22 Jul 2016

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Identification of novel DYNC2H1 mutations associated with short rib-polydactyly syndrome type III using next-generation panel sequencing.
 

Author(s): L S Chen, S J Shi, P S Zou, M Ma, X H Chen, D H Cao

Journal:

 

Short rib-polydactyly syndrome type III (SRPS3) is a perinatal lethal skeletal disorder with polydactyly and multisystem organ abnormalities. While ultrasound of the fetus can detect skeletal abnormalities characteristic of SRPS3, the syndrome is often difficult to diagnose before ...

Last Updated: 21 Jun 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Polydactyly" returned 5 free, full-text review articles on human participants. First 3 results:

Polydactyly: a review.
 

Author(s): Bev Guo, Steven K Lee, Nader Paksima

Journal: Bull Hosp Jt Dis (2013). 2013 ;71(1):17-23.

 

Polydactyly of the hand is a difficult problem and poses a unique challenge for the hand surgeon. The embryology of limb development is complex, leading to a host of different phenotypes of polydactyly. Polydactyly can occur in any digit and is described as preaxial, postaxial, and ...

Last Updated: 16 Sep 2013

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Holoprosencephaly-polydactyly/pseudotrisomy 13: a presentation of two new cases and a review of the literature.
 

Author(s): Sophia M Bous, Benjamin D Solomon, Luitgard Graul-Neumann, Heidemarie Neitzel, Emily E Hardisty, Maximilian Muenke

Journal: Clin. Dysmorphol.. 2012 Oct;21(4):183-90.

 

Patients with a combination of holoprosencephaly and polydactyly, but with apparently normal chromosomes, may be clinically diagnosed with holoprosencephaly-polydactyly syndrome (HPS), also termed pseudotrisomy 13. However, the criteria for HPS have been controversial since the advent ...

Last Updated: 30 Aug 2012

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Polydactyly: how many disorders and how many genes? 2010 update.
 

Author(s): Leslie G Biesecker

Journal: Dev. Dyn.. 2011 May;240(5):931-42.

 

Limb development is clinically and biologically important. Polydactyly is common and caused by aberrant anterior-posterior patterning. Human disorders that include polydactyly are diverse. To facilitate an understanding of the biology of limb development, cataloging the genes that ...

Last Updated: 21 Apr 2011

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.