Portal vein thrombosis

Common Name(s)

Portal vein thrombosis

Portal vein thrombosis is caused by a blood clot blocking or narrowing the vein that takes blood from the intestines to the spleen and liver. This situation can decrease or even stop blood flow to the liver. The portal vein is very important because about 75% of the liver’s blood supply comes through this vein. Portal vein thrombosis can cause serious liver damage due to lack of blood flow as well as an enlarged spleen and esophageal or gastric (stomach) varices (varicose veins in the esophagus or stomach caused by valves failing due to too much pressure in the veins or portal hypertension).

Symptoms may include fever, indigestion, and worsening abdominal pain. The spleen may be enlarged, causing pain. If the esophageal or gastric varices rupture or burst open, there will be a lot of bleeding which requires emergency treatment. If the person already has scarring of the liver (cirrhosis) due to liver disease, fluid may build up in the abdomen. However, not all affected individuals have noticeable symptoms.

In newborns, portal vein thrombosis is often caused by an infection of the umbilical cord stump. In older children, it may be caused by appendicitis. And in adults, portal vein thrombosis may be caused by having too many red blood cells; liver, pancreatic, kidney or adrenal gland cancers; injury; surgery; pregnancy; cirrhosis of the liver; or any condition which increases chances of blood clots. In one third of the cases, the cause is unknown.

To confirm a diagnosis, your doctor may use a Doppler ultrasound, an MRI or CT scan, or blood tests to check liver function. There are several medications available to treat portal vein thrombosis and help dissolve the blood clot. Talk to your doctor about the most current treatment options. Support organizations are good sources of information and can connect you to others affected by portal vein thrombosis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal vein thrombosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal vein thrombosis" returned 301 free, full-text research articles on human participants. First 3 results:

Mesocaval Shunt Creation for Jejunal Variceal Bleeding with Chronic Portal Vein Thrombosis.
 

Author(s): Ja Kyung Yoon, Man Deuk Kim, Do Yun Lee, Seok Joo Han

Journal: Yonsei Med. J.. 2018 Jan;59(1):162-166.

 

The creation of transjugular intrahepatic portosystemic shunt (TIPS) is a widely performed technique to relieve portal hypertension, and to manage recurrent variceal bleeding and refractory ascites in patients where medical and/or endoscopic treatments have failed. However, portosystemic ...

Last Updated: 31 Dec 1969

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Y-configuration stent combined with iodine-125 seeds strand for the treatment of hepatocellular carcinoma with tumor thrombosis in portal vein branches: A case report.
 

Author(s): Tan Tan, Yudong Xiao, Shunke Zhou, Cong Ma, Zishu Zhang

Journal: Medicine (Baltimore). 2017 Nov;96(46):e8660.

 

Currently, the treatment of hepatocellular carcinoma (HCC) associated with portal vein tumor thrombosis (PVTT) is a challenge. Percutaneous puncture endovascular placement of iodine-125 (I) seeds strand and stent is reported to treat HCC with tumor thrombus effectively. However, it ...

Last Updated: 31 Dec 1969

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Portal vein thrombosis before and after transjugular intrahepatic portosystemic shunt placement: An observational study (STROBE compliant).
 

Author(s): Yue-Meng Wan, Yu-Hua Li, Hua-Mei Wu, Zhi-Yuan Xu, Ying Xu, Li-Hong Yang, Xi-Nan Wu, Jin-Hui Yang

Journal: Medicine (Baltimore). 2017 Nov;96(45):e8498.

 

Portal vein thrombosis (PVT) is common in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS). This study had 3-fold aims: to assess risk factors for PVT; to determine the efficacy of anticoagulant therapy; to investigate the impact of PVT on clinical ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal vein thrombosis" returned 37 free, full-text review articles on human participants. First 3 results:

Fondaparinux is effective for acute portal vein thrombosis in decompensated cirrhotic patients.
 

Author(s): Zhi-Hao Zhang, Jing-Wen Zhang, Ping He, Yan Zhou, Chang-Yu Sun

Journal: Medicine (Baltimore). 2017 Oct;96(42):e8256.

 

Portal vein thrombosis (PVT) is a rare but serious complication in the decompensated stage of cirrhosis, and recurrent upper gastrointestinal bleeding and refractory ascites can occur in such patients. In decompensated cirrhotic patients, the application of conventional anticoagulant ...

Last Updated: 31 Dec 1969

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Postoperative inflammation as a possible cause of portal vein thrombosis after irreversible electroporation for locally advanced pancreatic cancer.
 

Author(s): Jun-Jun Su, Ming Su, Kai Xu, Peng-Fei Wang, Li Yan, Shi-Chun Lu, Wan-Qing Gu, Yong-Liang Chen

Journal: World J. Gastroenterol.. 2017 Aug;23(32):6003-6006.

 

Portal vein thrombosis (PVT) is a rare but serious postoperative complication associated with irreversible electroporation (IRE). We report a case of postoperative PVT in a 54-year-old woman who underwent IRE for locally advanced pancreatic cancer. Drain removal and discharge of the ...

Last Updated: 31 Dec 1969

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A systematic review on the safety and effectiveness of yttrium-90 radioembolization for hepatocellular carcinoma with portal vein tumor thrombosis.
 

Author(s): Zhongzhi Jia, Guomin Jiang, Feng Tian, Chunfu Zhu, Xihu Qin

Journal: Saudi J Gastroenterol. ;22(5):353-359.

 

Over the past two decades, several advances have been made in the management of patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT). Yttrium-90 ( 90 Y) radioembolization has recently been made a treatment option for patients with HCC and PVTT. However, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect of Anticoagulation in Cirrhotic Patients With Portal Vein Thrombosis:A Multicenter RCT
 

Status: Not yet recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 14 Dec 2015

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TIPS or Anticoagulation in Portal Vein Thrombosis
 

Status: Not yet recruiting

Condition Summary: Thrombosis Portal Vein

 

Last Updated: 13 Feb 2018

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TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis
 

Status: Recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 18 Jul 2017

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