Portal vein thrombosis

Common Name(s)

Portal vein thrombosis

Portal vein thrombosis is caused by a blood clot blocking or narrowing the vein that takes blood from the intestines to the spleen and liver. This situation can decrease or even stop blood flow to the liver. The portal vein is very important because about 75% of the liver’s blood supply comes through this vein. Portal vein thrombosis can cause serious liver damage due to lack of blood flow as well as an enlarged spleen and esophageal or gastric (stomach) varices (varicose veins in the esophagus or stomach caused by valves failing due to too much pressure in the veins or portal hypertension).

Symptoms may include fever, indigestion, and worsening abdominal pain. The spleen may be enlarged, causing pain. If the esophageal or gastric varices rupture or burst open, there will be a lot of bleeding which requires emergency treatment. If the person already has scarring of the liver (cirrhosis) due to liver disease, fluid may build up in the abdomen. However, not all affected individuals have noticeable symptoms.

In newborns, portal vein thrombosis is often caused by an infection of the umbilical cord stump. In older children, it may be caused by appendicitis. And in adults, portal vein thrombosis may be caused by having too many red blood cells; liver, pancreatic, kidney or adrenal gland cancers; injury; surgery; pregnancy; cirrhosis of the liver; or any condition which increases chances of blood clots. In one third of the cases, the cause is unknown.

To confirm a diagnosis, your doctor may use a Doppler ultrasound, an MRI or CT scan, or blood tests to check liver function. There are several medications available to treat portal vein thrombosis and help dissolve the blood clot. Talk to your doctor about the most current treatment options. Support organizations are good sources of information and can connect you to others affected by portal vein thrombosis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Portal vein thrombosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Portal vein thrombosis" returned 313 free, full-text research articles on human participants. First 3 results:

Interventional Treatment of Acute Portal Vein Thrombosis.
 

Author(s): Karsten Wolter, Georges Decker, Daniel Kuetting, Jonel Trebicka, Steffen Manekeller, Carsten Meyer, Hans Schild, Daniel Thomas

Journal: Rofo. 2018 08;190(8):740-746.

 

Acute portal vein thrombosis is a potentially fatal condition. In symptomatic patients not responding to systemic anticoagulation, interventional procedures have emerged as an alternative to surgery. This study sought to retrospectively evaluate initial results of interventional treatment ...

Last Updated: 31 Dec 1969

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Anticoagulation treatment of portal vein thrombosis in a patient with cirrhosis awaiting liver transplantation: A case report.
 

Author(s): Jian Wang, Jia-Sui Chai, Ya-Min Zhang

Journal: Medicine (Baltimore). 2018 Jun;97(26):e11183.

 

Portal vein thrombosis (PVT) is relatively common in patients with liver cirrhosis waiting for liver transplantation (LT). Anticoagulation is an important non-invasive treatment strategy for patients with cirrhosis and PVT.

Last Updated: 31 Dec 1969

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Acute portal vein thrombosis after hepatectomy in a patient with hepatolithiasis: A case report and review of the literature.
 

Author(s): Zun-Yi Zhang, Ke-Shuai Dong, Er-Lei Zhang, Zhi-Yong Huang, Xiao-Ping Chen, Han-Hua Dong

Journal: Medicine (Baltimore). 2018 Jun;97(25):e11174.

 

Portal vein thrombosis is defined as any thrombosis that develops in the portal vein system. It is considered a very rare and extremely lethal complication of hepatopancreatobiliary surgery.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Portal vein thrombosis" returned 40 free, full-text review articles on human participants. First 3 results:

Transient portal vein thrombosis in liver cirrhosis.
 

Author(s): Xingshun Qi, Xiaozhong Guo, Eric M Yoshida, Nahum Méndez-Sánchez, Valerio De Stefano, Frank Tacke, Andrea Mancuso, Yasuhiko Sugawara, Sien-Sing Yang, Rolf Teschke, Ankur Arora, Dominique-Charles Valla

Journal:

 

In real-world clinical practice, the acceptance of anticoagulation therapy in the management of portal vein thrombosis (PVT) in patients with cirrhosis is limited by the fear of an increased bleeding risk. Additionally, accumulating evidence indicates that spontaneous recanalization ...

Last Updated: 31 Dec 1969

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Fondaparinux is effective for acute portal vein thrombosis in decompensated cirrhotic patients.
 

Author(s): Zhi-Hao Zhang, Jing-Wen Zhang, Ping He, Yan Zhou, Chang-Yu Sun

Journal: Medicine (Baltimore). 2017 Oct;96(42):e8256.

 

Portal vein thrombosis (PVT) is a rare but serious complication in the decompensated stage of cirrhosis, and recurrent upper gastrointestinal bleeding and refractory ascites can occur in such patients. In decompensated cirrhotic patients, the application of conventional anticoagulant ...

Last Updated: 31 Dec 1969

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Postoperative inflammation as a possible cause of portal vein thrombosis after irreversible electroporation for locally advanced pancreatic cancer.
 

Author(s): Jun-Jun Su, Ming Su, Kai Xu, Peng-Fei Wang, Li Yan, Shi-Chun Lu, Wan-Qing Gu, Yong-Liang Chen

Journal: World J. Gastroenterol.. 2017 Aug;23(32):6003-6006.

 

Portal vein thrombosis (PVT) is a rare but serious postoperative complication associated with irreversible electroporation (IRE). We report a case of postoperative PVT in a 54-year-old woman who underwent IRE for locally advanced pancreatic cancer. Drain removal and discharge of the ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect of Rifaximin on Portal Vein Thrombosis
 

Status: Not yet recruiting

Condition Summary: Cirrhosis; Portal Vein Thrombosis

 

Last Updated: 12 Aug 2018

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TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis
 

Status: Recruiting

Condition Summary: Portal Vein Thrombosis; Liver Cirrhosis

 

Last Updated: 18 Jul 2017

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TIPS or Anticoagulation in Portal Vein Thrombosis
 

Status: Not yet recruiting

Condition Summary: Thrombosis Portal Vein

 

Last Updated: 13 Feb 2018

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