Preeclampsia/eclampsia 1

Common Name(s)

Preeclampsia/eclampsia 1

Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. Preeclampsia is 1 of the top 4 causes of maternal mortality and morbidity worldwide (summary by {40:Payne et al., 2011}). Preeclampsia is otherwise known as gestational proteinuric hypertension ({16:Davey and MacGillivray, 1988}). A high proportion of patients with preeclampsia have glomerular endotheliosis, the unique histopathologic feature of the condition ({19:Fisher et al., 1981}). A distinct form of severe preeclampsia is characterized by hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome) ({9:Brown et al., 2000}). Genetic Heterogeneity of Preeclampsia/Eclampsia Susceptibility loci for preeclampsia/eclampsia include PEE1 on chromosome 2p13, PEE2 ({609402}) on chromosome 2p25, and PEE3 ({609403}) on chromosome 9p13. PEE4 ({609404}) is caused by mutation in the STOX1 gene ({609397}) on chromosome 10q22. PEE5 ({614595}) is caused by mutation in the CORIN gene ({605236}) on chromosome 4p12. An association with PEE has been found with the EPHX1 gene ({132810}) on chromosome 1q.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Preeclampsia/eclampsia 1" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 8 May 2017

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Blood Collection to Validated New Therapeutics Strategies Against Preeclampsia
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 19 Jun 2017

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Low Dose Aspirin in the Prevention of Preeclampsia in China
 

Status: Recruiting

Condition Summary: Preeclampsia

 

Last Updated: 6 Dec 2016

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