Premature aging

Common Name(s)

Premature aging

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Premature aging" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Premature aging" returned 71 free, full-text research articles on human participants. First 3 results:

Nucleolar expansion and elevated protein translation in premature aging.
 

Author(s): Abigail Buchwalter, Martin W Hetzer

Journal:

 

Premature aging disorders provide an opportunity to study the mechanisms that drive aging. In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We sought to investigate protein homeostasis ...

Last Updated: 31 Dec 1969

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Dysfunction of the MDM2/p53 axis is linked to premature aging.
 

Author(s): Davor Lessel, Danyi Wu, Carlos Trujillo, Thomas Ramezani, Ivana Lessel, Mohammad K Alwasiyah, Bidisha Saha, Fuki M Hisama, Katrin Rading, Ingrid Goebel, Petra Schütz, Günter Speit, Josef Högel, Holger Thiele, Gudrun Nürnberg, Peter Nürnberg, Matthias Hammerschmidt, Yan Zhu, David R Tong, Chen Katz, George M Martin, Junko Oshima, Carol Prives, Christian Kubisch

Journal: J. Clin. Invest.. 2017 Oct;127(10):3598-3608.

 

The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin ligase MDM2 via an autoregulatory feedback loop. In addition to its well-established role in tumorigenesis, p53 has also been associated with aging in mice. Several ...

Last Updated: 31 Dec 1969

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Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics.
 

Author(s): Chenyue Ding, Hong Li, Yun Wang, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Wei Wang, Boxian Huang

Journal:

 

Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. Transplantation of human amniotic epithelial cells (hAECs) improves ovarian function damaged by chemotherapy in a mice model. Understanding of how to evaluate ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Premature aging" returned 21 free, full-text review articles on human participants. First 3 results:

The Potential of iPSCs for the Treatment of Premature Aging Disorders.
 

Author(s): Claudia Compagnucci, Enrico Bertini

Journal:

 

Premature aging disorders including Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome, are a group of rare monogenic diseases leading to reduced lifespan of the patients. Importantly, these disorders mimic several features of physiological aging. Despite the interest ...

Last Updated: 31 Dec 1969

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Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.
 

Author(s): Susana Gonzalo, Ray Kreienkamp, Peter Askjaer

Journal: Ageing Res. Rev.. 2017 Jan;33():18-29.

 

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is essential for proper nuclear architecture. Alterations in lamin A and C that disrupt the integrity of the nuclear ...

Last Updated: 31 Dec 1969

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Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.
 

Author(s): Christelle de Renty, Nathan A Ellis

Journal: Ageing Res. Rev.. 2017 Jan;33():36-51.

 

Genomic instability is a hallmark of cancer and aging. Premature aging (progeroid) syndromes are often caused by mutations in genes whose function is to ensure genomic integrity. The RecQ family of DNA helicases is highly conserved and plays crucial roles as genome caretakers. In ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical Trial to Evaluate the Addition to an Antiretroviral Treatment of a Probiotic
 

Status: Recruiting

Condition Summary: HIV; Premature Aging

 

Last Updated: 31 May 2018

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White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study
 

Status: Recruiting

Condition Summary: Aging, Premature; Congenital Heart Disease; White Matter Hyperintensities

 

Last Updated: 3 Apr 2018

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Mental Ability Challenge Study in Adults With and Without HIV
 

Status: Recruiting

Condition Summary: HIV-1-infection; Aging, Premature; Cognitive Impairment; Memory Impairment; HIV-Associated Cognitive Motor Complex

 

Last Updated: 9 Aug 2018

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