Premature chromatid separation trait

Common Name(s)

Premature chromatid separation trait

Premature chromatid separation consists of separate and splayed chromatids with discernible centromeres and involves all or most chromosomes of a metaphase. It is found in up to 2% of metaphases in cultured lymphocytes from approximately 40% of normal individuals. When PCS is present in 5% or more of cells, it is known as the 'heterozygous PCS trait' and has no obvious phenotypic effect, although some have reported decreased fertility ({4:Gabarron et al., 1986}). Inheritance is autosomal codominant ({7:Kajii and Ikeuchi, 2004}). See also {158250} for a possible inherited predisposition to nondisjunction, which may be a related phenomenon.
 

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Scientific Literature

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