Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 275 free, full-text research articles on human participants. First 3 results:

The effect of adrenalectomy on exercise response of the renin-angiotensin-aldosterone system and exercise tolerance in primary aldosteronism.
 

Author(s): V Tuka, M Matoulek, J Rosa, O Petrák, O Mikeš, Z Krátká, B Štrauch, R Holaj, T Zelinka, J Widimský

Journal: Physiol Res. 2018 May;67(2):233-238.

 

Primary aldosteronism (PA) is associated with objectively measured lower physical fitness and blunted response of the renin-angiotensin-aldosterone system to exercise. The purpose of this pilot study was to objectively measure exercise response of the renin-angiotensin-aldosterone ...

Last Updated: 31 Dec 1969

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The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension: A Cohort Study.
 

Author(s): Jenifer M Brown, Cassianne Robinson-Cohen, Miguel Angel Luque-Fernandez, Matthew A Allison, Rene Baudrand, Joachim H Ix, Bryan Kestenbaum, Ian H de Boer, Anand Vaidya

Journal: Ann. Intern. Med.. 2017 Nov;167(9):630-641.

 

Primary aldosteronism is recognized as a severe form of renin-independent aldosteronism that results in excessive mineralocorticoid receptor (MR) activation.

Last Updated: 31 Dec 1969

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Biventricular Cardiac Hypertrophy in a Patient with Primary Aldosteronism and Atrial Septal Defect.
 

Author(s): Tjokorda Gde Dalem Pemayun, Ridho M Naibaho, Muhammad Achmad Sungkar

Journal:

 

BACKGROUND Primary aldosteronism can be caused by adrenocortical adenoma and is usually associated with left ventricular hypertrophy. Biventricular cardiac hypertrophy and heart failure in the presence of a pre-existing atrial septal defect (ASD) are a rare association of primary ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 49 free, full-text review articles on human participants. First 3 results:

Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism.
 

Author(s): Elke Tatjana Aristizabal Prada, Isabella Castellano, Eva Sušnik, Yuhong Yang, Lucie S Meyer, Martina Tetti, Felix Beuschlein, Martin Reincke, Tracy A Williams

Journal:

 

Primary aldosteronism is the most common form of endocrine hypertension with a prevalence of 6% in the general population with hypertension. The genetic basis of the four familial forms of primary aldosteronism (familial hyperaldosteronism FH types I-IV) and the majority of sporadic ...

Last Updated: 31 Dec 1969

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Hypertension outcomes of adrenalectomy in patients with primary aldosteronism: a systematic review and meta-analysis.
 

Author(s): Yu Zhou, Meilian Zhang, Sujie Ke, Libin Liu

Journal:

 

The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies.

Last Updated: 31 Dec 1969

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Management of primary aldosteronism in patients with adrenal hemorrhage following adrenal vein sampling: A brief review with illustrative cases.
 

Author(s): Fady Hannah-Shmouni, Andrew Demidowich, Beatriz Rizkallah Alves, Gabriela Dockhorn Paluch, Dionysiou Margarita, Charalampos Lysikatos, Elena Belyavskaya, Richard Chang, Constantine A Stratakis

Journal: J Clin Hypertens (Greenwich). 2017 Dec;19(12):1372-1376.

 

The authors describe the clinical investigation of two cases of primary aldosteronism with adrenal hemorrhage (AH) following adrenal vein sampling. A literature review was conducted regarding the medical management of primary aldosteronism in patients with AH following adrenal vein ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Chongqing Primary Aldosteronism Study
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 19 Jul 2017

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Open-label Study on Treatment of Primary Aldosteronism With Everolimus
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 4 Jun 2018

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Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Diagnosis of Primary Aldosteronism

 

Last Updated: 9 Apr 2018

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