Primary aldosteronism

Common Name(s)

Primary aldosteronism, Conn's syndrome

Primary aldosteronism, also known as Conn's syndrome, is considered one of the most common causes of secondary hypertension or high blood pressure. Primary aldosteronism occurs when your body produces too much aldosterone, which is a hormone that controls the sodium and patassium levels in the blood. When too much aldosterone is produced, the result is too much salt (sodium) and too little potassium in the blood, which leads to hypertension. Conn's syndrome is more common in females than males and can occur at any age, but most commonly in people in their 30s and 40s. Symptoms may include muscle weakness, frequent urination, excessive thirst, or muscle twitching and cramps. Medical therapy is a good treatment option.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary aldosteronism" returned 348 free, full-text research articles on human participants. First 3 results:

The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension: A Cohort Study.
 

Author(s): Jenifer M Brown, Cassianne Robinson-Cohen, Miguel Angel Luque-Fernandez, Matthew A Allison, Rene Baudrand, Joachim H Ix, Bryan Kestenbaum, Ian H de Boer, Anand Vaidya

Journal: Ann. Intern. Med.. 2017 Nov;167(9):630-641.

 

Primary aldosteronism is recognized as a severe form of renin-independent aldosteronism that results in excessive mineralocorticoid receptor (MR) activation.

Last Updated: 31 Dec 1969

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Biventricular Cardiac Hypertrophy in a Patient with Primary Aldosteronism and Atrial Septal Defect.
 

Author(s): Tjokorda Gde Dalem Pemayun, Ridho M Naibaho, Muhammad Achmad Sungkar

Journal:

 

BACKGROUND Primary aldosteronism can be caused by adrenocortical adenoma and is usually associated with left ventricular hypertrophy. Biventricular cardiac hypertrophy and heart failure in the presence of a pre-existing atrial septal defect (ASD) are a rare association of primary ...

Last Updated: 31 Dec 1969

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A case of Adrenocoricotrophic hormone -independent bilateral adrenocortical macronodular hyperplasia concomitant with primary aldosteronism.
 

Author(s): Mao Tokumoto, Naoyoshi Onoda, Yukie Tauchi, Shinichiro Kashiwagi, Satoru Noda, Norikazu Toi, Masahumi Kurajoh, Masahiko Ohsawa, Yuto Yamazaki, Hironobu Sasano, Kosei Hirakawa, Masaichi Ohira

Journal:

 

Adrenocoricotrophic hormone (ACTH) - independent bilateral adrenocortical macronodular hyperplasia (AIMAH) is a rare cause of Cushing's syndrome, and is characterized by bilateral adrenal hyperplasia. However, Primary aldosteronism (PA) is a relatively common adrenal disease.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary aldosteronism" returned 55 free, full-text review articles on human participants. First 3 results:

GENETICS IN ENDOCRINOLOGY: The expanding genetic horizon of primary aldosteronism.
 

Author(s): Silvia Monticone, Fabrizio Buffolo, Martina Tetti, Franco Veglio, Barbara Pasini, Paolo Mulatero

Journal: Eur. J. Endocrinol.. 2018 Mar;178(3):R101-R111.

 

Aldosterone is the main mineralocorticoid hormone in humans and plays a key role in maintaining water and electrolyte homeostasis. Primary aldosteronism (PA), characterized by autonomous aldosterone overproduction by the adrenal glands, affects 6% of the general hypertensive population ...

Last Updated: 31 Dec 1969

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Diagnosis and management of primary aldosteronism.
 

Author(s): Leticia A P Vilela, Madson Q Almeida

Journal: Arch Endocrinol Metab. ;61(3):305-312.

 

Primary aldosteronism (PA) is the most common form of secondary hypertension (HTN), with an estimated prevalence of 4% of hypertensive patients in primary care and around 10% of referred patients. Patients with PA have higher cardiovascular morbidity and mortality than age- and sex-matched ...

Last Updated: 31 Dec 1969

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Subtype Diagnosis of Primary Aldosteronism: Is Adrenal Vein Sampling Always Necessary?
 

Author(s): Fabrizio Buffolo, Silvia Monticone, Tracy A Williams, Denis Rossato, Jacopo Burrello, Martina Tetti, Franco Veglio, Paolo Mulatero

Journal:

 

Aldosterone producing adenoma and bilateral adrenal hyperplasia are the two most common subtypes of primary aldosteronism (PA) that require targeted and distinct therapeutic approaches: unilateral adrenalectomy or lifelong medical therapy with mineralocorticoid receptor antagonists. ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Chongqing Primary Aldosteronism Study
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 19 Jul 2017

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Open-label Study on Treatment of Primary Aldosteronism With Everolimus
 

Status: Recruiting

Condition Summary: Primary Aldosteronism

 

Last Updated: 30 May 2017

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Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism
 

Status: Recruiting

Condition Summary: Diagnosis of Primary Aldosteronism

 

Last Updated: 9 Apr 2018

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