Primary open angle glaucoma

Common Name(s)

Primary open angle glaucoma

Primary open-angle glaucoma is a condition in which there is a blockage of fluid drainage from the eye. When fluid cannot drain properly from the eye, the pressure inside the eye may rise to a level that can damage the optic nerve. The optic nerve is the nerve that brings information from the back of the eye (retina), and damage to this nerve can result in vision loss and blindness.

Primary open-angle glaucoma is the most common form of glaucoma. It affects at least 3 million Americans. In primary open-angle glaucoma, fluid builds up in the anterior chamber of the eye because it cannot drain through a meshwork structure between the colored part of the eye that controls light entry (iris) and the lens of the eye (cornea). In primary open-angle glaucoma, the spacing between the iris and cornea is normal. The risk of developing primary open-angle glaucoma increases with age, especially above age 50, and is higher in those with a family history of this condition. Primary open-angle glaucoma can be asymptomatic or may have symptoms of decreased vision, particularly in the side or periphery, as well as pain, nausea, and headache.

Primary open-angle glaucoma can be diagnosed with a comprehensive dilated eye exam and by measuring intraocular pressure (IOP). Regular eye exams are important because this form of glaucoma is often asymptomatic prior to permanent vision loss. Treatment options include medication, laser surgery to create holes in the meshwork and allow fluid to drain from the anterior chamber (laser trabeculoplasty), and surgery to alter the iris to allow fluid drainage. If you have been diagnosed with primary open-angle glaucoma, talk to your doctor about the most current treatment options. Support groups are good sources of more information and can connect you with other people living with glaucoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

Logo
The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary open angle glaucoma" returned 530 free, full-text research articles on human participants. First 3 results:

Factors associated with developing a fear of falling in subjects with primary open-angle glaucoma.
 

Author(s): Sayaka Adachi, Kenya Yuki, Sachiko Awano-Tanabe, Takeshi Ono, Daisuke Shiba, Hiroshi Murata, Ryo Asaoka, Kazuo Tsubota

Journal:

 

To investigate the relationship between clinical risk factors, including visual field (VF) defects and visual acuity, and a fear of falling, among patients with primary open-angle glaucoma (POAG).

Last Updated: 31 Dec 1969

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Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma.
 

Author(s): Masoud Aghsaei Fard, Yanin Suwan, Sasan Moghimi, Lawrence S Geyman, Toco Y Chui, Richard B Rosen, Robert Ritch

Journal:

 

Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we compared peripapillary capillary density (PCD) ...

Last Updated: 31 Dec 1969

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Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7.
 

Author(s): Yukihiro Shiga, Koji M Nishiguchi, Yosuke Kawai, Kaname Kojima, Kota Sato, Kosuke Fujita, Mai Takahashi, Kazuko Omodaka, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Nobuo Fuse, Masayuki Yamamoto, Jun Yasuda, Masao Nagasaki, Toru Nakazawa,

Journal:

 

To test the genetic association between Japanese patients with primary open-angle glaucoma (POAG) and the previously reported POAG susceptibility loci and to perform genotype-phenotype analysis.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary open angle glaucoma" returned 27 free, full-text review articles on human participants. First 3 results:

Association of WDR36 polymorphisms with primary open angle glaucoma: A systematic review and meta-analysis.
 

Author(s): Ke Liu, Wenling He, Jun Zhao, Yingxia Zeng, Hongbo Cheng

Journal: Medicine (Baltimore). 2017 Jun;96(26):e7291.

 

The association of the WDR36 gene with glaucoma has been controversial in the literature. We therefore conducted a systematic review and meta-analysis to assess the association of all reported common polymorphisms in WDR36 with primary open angle glaucoma (POAG) and its subtypes: ...

Last Updated: 31 Dec 1969

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Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma.
 

Author(s): Louise J Lu, James C Tsai, Ji Liu

Journal:

 

Primary open-angle glaucoma (OAG) affects approximately 45 million people worldwide and more than 2.5 million people aged 40 years or older in the United States. Pharmacologic treatment for glaucoma is directed towards lowering intraocular pressure (IOP) to slow disease progression ...

Last Updated: 31 Dec 1969

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Association between the p53 codon 72 polymorphism and primary open-angle glaucoma risk: Meta-analysis based on 11 case-control studies.
 

Author(s): Mohsen Gohari, Hossein Neámatzadeh, Mohammad Ali Jafari, Mahta Mazaheri, Masoud Zare-Shehneh, Elahe Abbasi-Shavazi

Journal: Indian J Ophthalmol. 2016 Oct;64(10):756-761.

 

The TP53 is important in functions of cell cycle control, apoptosis, and maintenance of DNA integrity. Studies on the association between p53 codon 72 polymorphism and primary open-angle glaucoma (POAG) risk have yielded conflicting results. Published literature from PubMed and Web ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM)
 

Status: Recruiting

Condition Summary: Primary Open-angle Glaucoma

 

Last Updated: 6 Feb 2018

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Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma
 

Status: Recruiting

Condition Summary: Ocular Hypertension, Primary Open-angle Glaucoma (POAG)

 

Last Updated: 4 Jan 2018

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Surgical Approaches in Treating Uncontrolled Glaucoma in Black African and African-Caribbeans
 

Status: Recruiting

Condition Summary: Primary Open Angle Glaucoma

 

Last Updated: 7 Dec 2016

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